- Letter to the Editor
- Open Access
Intraductal fibroadenoma under the nipple in an 11-year-old female
© Hayano et al.; licensee BioMed Central Ltd. 2014
- Received: 9 December 2013
- Accepted: 6 January 2014
- Published: 10 February 2014
Recently, Chung et al. have reported the detailed clinicopathological features of an extremely rare case sharing similar histopathological characteristics with fibroadenomas, phyllodes tumours, intraductal papillomas or ductal adenomas, given the name of intraductal fibroadenomatosis, as an unusual variant of intracanalicular fibroadenoma. Herein we demonstrated a very unusual case of intraductal fibroadenoma of the breast with admixture of components of intracanalicular type fibroadenoma or benign phyllodes tumour and a smaller amount of intraductal papilloma, occupying the one duct and some adjacent ductules, presenting as a well-demarcated nodule.
- Intraductal fibroadenoma
- Intracanalicular type fibroadenoma
- Phyllodes tumour
In 2008, Chung et al. have demonstrated the detailed clinicopathological features of an extremely rare case sharing similar histopathological characteristics with fibroadenomas, phyllodes tumors, intraductal papillomas or ductal adenomas, given the name as intraductal fibroadenomatosis, as a very unusual variant of intracanalicular fibroadenoma . Following that, there also have been two interesting reported cases describing pathological features with regard to an intraductal fibroepithelial and papillomatous proliferation corresponding to not only fibroadenomas but phyllodes tumours . Herein we reported an extremely rare case of intraductal fibroadenoma of the breast with admixture of components of intracanalicular type fibroadenoma or phyllodes tumour and a smaller amount of intraductal papilloma, occupying the one duct and some adjacent ductules, presenting as a well-demarcated nodule.
In fact, fibroadenomas or phyllodes tumours are common diseases, compared with some recently published case reports of very rare tumor cell types or very unusual features in the breast [4, 5]. Despite that, we report the present extremely rare case, since it is very likely that the current short report of intraductal fibroadenoma located on the subareolar region is clinicopathologically remarkable for two reasons at least. First, our case unusually occurred in very young girl of adolescence, but not adulthood. Actually, Cummings et al. have reported that a 13-year-old female case includes foci comprising typical intraductal papillomas, some with leaf-like contours, demonstrating a low-grade phyllodes tumour-like proliferation, admixed with a small amount of fibroadenoma areas . Intraductal fibroadenomas seem to have a special predilection for adolescent female, and might be more common than clinicopathologically considered among the young girls. Second, the present case shares several histopathological characteristics with fibroadenomas, benign phyllodes tumours, and intraductal papillomas, respectively, however, unlike the reported cases [1, 2], our main features were of intracanalicular type fibroadenomas or benign phyllodes tumours with conspicuous myxoid stromal change, appearing as leaf-like processes and protruding into intraductal cystic spaces as grossly polypoid lesions. In fact, phyllodes tumours occasionally exhibit intracanalicular growth pattern in elongated and dilated lumina [1, 3]. Based on these characteristic clinicopathological features, it is possible that intraductal fibroadenoma might be established as a special new entity of the breast benign tumour. It would be intriguing to study this topic after collecting and investigating a number of cases of intraductal fibroadenoma. The present short case report could interest the scientific community, taken together with some new findings and specific recommendations for histological diagnostics.
Written informed consent was obtained from the patient’s parents of kin for the publication of this report and any accompanying images.
- Chung A, Scharre K, Wilson M: Intraductal fibroadenomatosis: an unusual variant of fibroadenoma. Breast J. 2008, 14: 193-195. 10.1111/j.1524-4741.2007.00553.x.PubMedView ArticleGoogle Scholar
- Cummings MC, da Silva L, Papadimos DJ, Lakhani S: Fibroadenoma and intraduct papilloma–a common pathogenesis?. Virchows Arch. 2009, 455: 271-275. 10.1007/s00428-009-0817-8.PubMedView ArticleGoogle Scholar
- Bezić J: Intraductal fibroadenoma and intraductal phyllodes tumour–a part of the spectrum of the breast ductal adenoma?. Virchows Arch. 2010, 456: 105-106. 10.1007/s00428-009-0870-3.PubMedView ArticleGoogle Scholar
- Yamada S, Nabeshima A, Nagata Y, Tasaki T, Noguchi H, Kitada S, Kimura S, Wang KY, Shimajiri S, Sasaguri Y: Pleomorphic carcinoma of the breast associated with cyst formation: a unique surgical case focusing on cytological and immunohistochemical findings. Cystic breast PC. Diagn Pathol. 2013, 8: 75-10.1186/1746-1596-8-75.PubMedPubMed CentralView ArticleGoogle Scholar
- Skenderi F, Krakonja F, Vranic S: Infarcted fibroadenoma of the breast: report of two new cases with review of the literature. Diagn Pathol. 2013, 8: 38-10.1186/1746-1596-8-38.PubMedPubMed CentralView ArticleGoogle Scholar
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