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Table 5 Stratification analysis of IL-22 + 1046 T/A polymorphisms in ulcerative colitis cases

From: Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

 

Cases (n = 180)

TT

TA

AA

n (%)

OR (95% CI)

P

n (%)

OR (95% CI)

P

n (%)

OR (95% CI)

P

Clinical type

180

88(48.9)

1(Reference)

 

63(35.0)

1(Reference)

 

29(16.1)

1(Reference)

 

One episode

16

7(43.7)

0.89(0.35,2.55)

0.81

6(37.6)

1.07(0.40,2.86)

0.89

3(18.7)

1.16(0.32,4.25)

0.82

Relapsing

70

33(47.1)

0.96(0.59,1.57)

0.88

26(37.2)

1.06(0.62,1.81)

0.83

11(15.7)

0.98(0.46,2.06)

0.95

Continuous

94

48(51.1)

1.04(0.68,1.61)

0.84

31(33.0)

0.94(0.57,1.55)

0.82

15(15.9)

0.99(0.51,1.94)

0.98

Location

180

88(48.9)

1(Reference)

 

63(35.0)

1(Reference)

 

29(16.1)

1(Reference)

 

Proctitis (E1)

73

37(50.7)

1.04(0.65,1.66)

0.88

25(34.2)

0.98(0.57,1.67)

0.94

11(15.1)

0.94(0.44,1.97)

0.86

Left side (E2)

64

33(51.6)

1.06(0.65,1.72)

0.83

21(32.8)

0.94(0.53,1.66)

0.82

10(15.6)

0.97(0.45,2.10)

0.94

Extensive (E3)

43

18(41.9)

0.86(0.47,1.57)

0.62

17(39.5)

1.13(0.60,2.12)

0.70

8(18.6)

1.16(0.49,2.70)

0.74

Disease severity

180

88(48.9)

1(Reference)

 

63(35.0)

1(Reference)

 

29(16.1)

1(Reference)

 

Mild

76

35(46.1)

0.94(0.59,1.51)

0.81

28(36.8)

1.05(0.63,1.77)

0.85

13(17.1)

1.06(0.52,2.15)

0.87

Moderate

95

48(50.5)

1.03(0.67,1.59)

0.88

32(33.7)

0.96(0.59,1.58)

0.88

15(15.8)

0.98(0.50,1.92)

0.95

Severe

9

5(55.6)

1.14(0.37,3.49)

0.82

3(33.3)

0.95(0.25,3.63)

0.94

1(11.1)

0.69(0.08,5.65)

0.73

  1. Abbreviations: OR odds ratio, CI confidence interval.