Fig. 3
From: N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma
NDRG2 gene expression associations with PAs hormones. a Box plots of medians of NDRG2 mRNA expression in PRL, IGF-1, GH, ACTH, COR, multiple hormone groups and nonfunctioning PAs. The line inside each box represents the median, the lower and upper edges of the boxes represent the 25th and 75th percentiles, respectively, and upper and lower lines outside the boxes represent minimum and maximum values (error bars). PRL – prolactin, IGF-1 – insulin-like grow factor 1, GH – growth hormone, ACTH – adrenocorticotropic hormone, multiple – PAs secreting more than one hormone, NS – non-secreting PAs. b Hormones distribution in low, medium and high NDRG2 expression levels. Significantly increased amount of PRL hormone was observed at medium NDRG2 mRNA expression level (* p < 0.05)