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Table 1 Summary of the characteristics of patients with double ALK fusions reported in previous case reports

From: Concomitant novel ALK-SSH2, EML4-ALK and ARID2-ALK, EML4-ALK double-fusion variants and confer sensitivity to crizotinib in two lung adenocarcinoma patients, respectively

Ref.

Study

Age

Gender

Smoking

ALK fusion variants

Response to crizotinib

[13]

Xuan Wu, et al. 2020

32

Male

Smoker

CCNY-ALK, and ATIC-ALK

Yes

[14]

Xueqian Wu, et al. 2020

64

Female

Non-smoker

NLRC4-ALK, and EML4ALK

Yes

[15]

Jing Luo, et al. 2019

44

Male

Smoker

PRKCB-ALK, and EML4-ALK

Yes

[16]

Bao Dong Qin, et al. 2019

29

Male

Smoker

EML4-ALK, and BCL11A-ALK

Yes

[17]

Hao Lin, et al. 2018

56

Male

Not available

EML6-ALK, and FBXO11-ALK

Yes

[18]

Jinping Yin, et al. 2018

44

Male

Smoker

DYSF-ALK, and ITGAV-ALK

Yes