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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  3. The assessment of TP53 mutational status is becoming a routine clinical practice for chronic lymphocytic leukemia patients (CLL). A broad spectrum of molecular techniques has been employed so far, including both ...

    Authors: Crescenzio Francesco Minervini, Cosimo Cumbo, Paola Orsini, Claudia Brunetti, Luisa Anelli, Antonella Zagaria, Angela Minervini, Paola Casieri, Nicoletta Coccaro, Giuseppina Tota, Luciana Impera, Annamaria Giordano, Giorgina Specchia and Francesco Albano
    Citation: Diagnostic Pathology 2016 11:96
    Content type: Methodology Published on:

  4. A high-quality programmed cell-death ligand 1 (PD-L1) diagnostic assay may help predict which patients are more likely to respond to anti-programmed cell death-1 (PD-1)/PD-L1 antibody-based cancer therapy. Her...

    Authors: Marlon C. Rebelatto, Anita Midha, Amita Mistry, Constantine Sabalos, Nicole Schechter, Xia Li, Xiaoping Jin, Keith E. Steele, Paul B. Robbins, John A. Blake-Haskins and Jill Walker
    Citation: Diagnostic Pathology 2016 11:95
    Content type: Research Published on:

  5. Understanding the role of alternative complement pathway dysregulation in membranoproliferative glomerulonephritis (MPGN) has led to a dramatic shift in its classification into two subgroups: immune complex-me...

    Authors: Tanja Kersnik Levart, Dušan Ferluga, Alenka Vizjak, Jerica Mraz and Nika Kojc
    Citation: Diagnostic Pathology 2016 11:94
    Content type: Case Report Published on:

  6. Hot-spot based examination of immunohistochemically stained histological specimens is one of the most important procedures in pathomorphological practice. The development of image acquisition equipment and com...

    Authors: Zaneta Swiderska-Chadaj, Tomasz Markiewicz, Bartlomiej Grala and Malgorzata Lorent
    Citation: Diagnostic Pathology 2016 11:93
    Content type: Research Published on:

  7. Bangladesh, with a population of 160 million and nearly half being women, has the 4th highest rate of cervical carcinoma deaths in the world. It is projected that ∼500,000 of these women would die of this enti...

    Authors: Shabnam Akhter, Pradip Manna, Mohammed Kamal, C. James Sung, W. Dwayne Lawrence and M. Ruhul Quddus
    Citation: Diagnostic Pathology 2016 11:92
    Content type: Research Published on:

  8. The tumor suppressor gene CDC73 was found to be associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is characterized by parathyroid adenoma or carcinoma, ossifying fibroma (OF) of the jaws, and...

    Authors: Yan Chen, Da-Yan Hu, Ting-Ting Wang, Ran Zhang, Qing Dong, Zhi-Xiu Xu, Lin Wang and Tie-Jun Li
    Citation: Diagnostic Pathology 2016 11:91
    Content type: Research Published on:

  9. Many studies have been published on the mutational status of patients with lung adenocarcinomas, and great population-based variability in mutation frequencies has been reported. The main objective of the pres...

    Authors: Luka Brcic, Marko Jakopovic, Marija Misic, Fran Seiwerth, Izidor Kern, Silvana Smojver-Jezek, Franz Quehenberger, Miroslav Samarzija and Sven Seiwerth
    Citation: Diagnostic Pathology 2016 11:90
    Content type: Research Published on:

  10. The World Health Organization (WHO) classification system defines recurrent chromosomal translocations as the sole diagnostic and prognostic criteria for acute leukemia (AL). These fusion transcripts are pivot...

    Authors: Ariz Akhter, Muhammad Kashif Mughal, Ghaleb Elyamany, Gary Sinclair, Raja Zahratul Azma, Noraidah Masir, Salwati Shuib, Fariborz Rashid-Kolvear, Meer-Taher Shabani-Rad, Douglas Allan Stewart and Adnan Mansoor
    Citation: Diagnostic Pathology 2016 11:89
    Content type: Research Published on:

  11. ESCC is a life-threatening disease due to invasion and metastasis in the early stage. Great efforts had been made to detect the molecular mechanisms which led to the invasion and metastasis in ESCC. Recent evi...

    Authors: Feng Wang, Jun Wang, Xuan Yang, Danjie Chen and Liuxing Wang
    Citation: Diagnostic Pathology 2016 11:88
    Content type: Research Published on:

  12. Branchial cleft anomalies constitute a frequently encountered and commonly non-lethal disease in otolaryngology, and result from aberrant embryonic development. The third branchial cleft fistula is one of the ...

    Authors: Fang Tong, Yue Liang, Muhammad Fasahat Khan, Lin Zhang, Wenhe Li, Mohammed Mahmoodurrahman and Yiwu Zhou
    Citation: Diagnostic Pathology 2016 11:87
    Content type: Case Report Published on:

  13. The concomitant presence of idiopathic membranous nephropathy and IgA nephropathy is rare. Here, we report 9 cases of phospholipase-A2-receptor (PLA2R) positive idiopathic membranous nephritis combined with Ig...

    Authors: Ruimin Hu, Guolan Xing, Huijuan Wu and Zhigang Zhang
    Citation: Diagnostic Pathology 2016 11:86
    Content type: Case Report Published on:

  14. Human epidermal growth factor receptor 2 (HER2) is as a target gene for trastuzumab in patients with breast cancer. Accurate determination of HER2 status and strict quality control are necessary to ensure reprodu...

    Authors: Yulong Li, Rui Zhang, Yanxi Han, Tian Lu, Jiansheng Ding, Kuo Zhang, Guigao Lin, Jiehong Xie and Jinming Li
    Citation: Diagnostic Pathology 2016 11:85
    Content type: Research Published on:

  15. Authors: Rahim Hobbenaghi, Paria Mahboub, Siamak Saifzadeh, Javad Javanbakht, Javad Yaghoobi Yeganeh Manesh, Rasool Mortezaee, Seyed Rashid Touni, Ehsan Hosseini, Shahin Aghajanshakeri, Milad Moloudizargari and Soheil Javaherypour
    Citation: Diagnostic Pathology 2016 11:84
    Content type: Erratum Published on:

    The original article was published in Diagnostic Pathology 2014 9:59

  16. Primary anaplastic large cell lymphoma, ALK positive in small intestine is clinically rare and the clinical, radiological and pathological information are generally not available. Here, we report a case of...

    Authors: Qinghua Cao, Fang Liu, Shurong Li, Ni Liu, Lihui Li, Changzhao Li and Tingsheng Peng
    Citation: Diagnostic Pathology 2016 11:83
    Content type: Case Report Published on:

  17. Gene expression studies have identified molecular subtypes of breast cancer with implications to chemotherapy recommendations. For distinction of these types, a combination of immunohistochemistry (IHC) marker...

    Authors: Justinas Besusparis, Benoit Plancoulaine, Allan Rasmusson, Renaldas Augulis, Andrew R. Green, Ian O. Ellis, Aida Laurinaviciene, Paulette Herlin and Arvydas Laurinavicius
    Citation: Diagnostic Pathology 2016 11:82
    Content type: Research Published on:

  18. Perivascular epithelioid-cell tumor (PEComa) is a group of rare mesenchymal neoplasms that express myomelanocytic-cell markers and exhibit a wide variety of histopathological features. Although heterotopic pan...

    Authors: Yuka Kiriyama, Tetsuya Tsukamoto, Yoshikazu Mizoguchi, Shin Ishihara, Akihiko Horiguchi, Takamasa Tokoro, Yutaro Kato, Atsushi Sugioka and Makoto Kuroda
    Citation: Diagnostic Pathology 2016 11:81
    Content type: Case Report Published on:

  19. Primary bone lymphomas (PBL) are extremely rare malignant neoplasms. The most commonly described subtype of PBL is diffuse large B-cell lymphoma (DLBCL). DLBCL within peri-prosthetic membrane of a joint is exc...

    Authors: Sandra Sunitsch, Magdalena Gilg, Karl Kashofer, Andreas Leithner, Bernadette Liegl-Atzwanger and Christine Beham-Schmid
    Citation: Diagnostic Pathology 2016 11:80
    Content type: Case Report Published on:

  20. Regenerating gene (REG) family is composed of antiapoptotic factors and growth factors that affect epithelial cells within the digestive system. Regenerating gene-I has been studied in different cancers. Howev...

    Authors: Mohamed Aboshanif, Yohei Kawasaki, Yasufumi Omori, Shinsuke Suzuki, Kohei Honda, Satoru Motoyama and Kazuo Ishikawa
    Citation: Diagnostic Pathology 2016 11:79
    Content type: Research Published on:

  23. Germ cell tumors are tumors composed of tissues derived from more than one of the three germinal layers. They are more common in the testes and ovaries, but can present in many different regions in the midline...

    Authors: Radamés Ádamo Zuquello, Giordano Tagliari, Rodrigo Bagatini, Ricardo Hohmann Camiña, Ruggero Caron, Nadia Aparecida Lorencette, Antuani Rafael Baptistella and Gabriel Manfro
    Citation: Diagnostic Pathology 2016 11:76
    Content type: Case Report Published on:

  24. Pseudomyogenic hemangioendothelioma (PHE) is an unusual vascular tumor of intermediate malignancy that rarely metastasizes and tends to arise in the lower limbs of young adults and children. Histologically, PH...

    Authors: Shintaro Sugita, Hiroshi Hirano, Noriaki Kikuchi, Terufumi Kubo, Hiroko Asanuma, Tomoyuki Aoyama, Makoto Emori and Tadashi Hasegawa
    Citation: Diagnostic Pathology 2016 11:75
    Content type: Research Published on:

  25. Ewing sarcoma is the second most common bone tumor, occurring mainly in children and young adults. It shows a typical primitive, small round cell morphology and a characteristic fusion oncogene involving EWSR1 an...

    Authors: Maria Carolina Wilhelmina Salet, Rob Vogels, Paul Brons, Bart Schreuder and Uta Flucke
    Citation: Diagnostic Pathology 2016 11:74
    Content type: Case Report Published on:

  26. Pleomorphic xanthoastrocytoma is rare, accounting for <1 % of all central nervous system (CNS) neoplasms. Angiomatous pleomorphic xanthoastrocytoma is an extremely rare variant of pleomorphic xanthoastrocytoma...

    Authors: Yue-Feng Jiang, Yang Liu, Ye-Lin Wang, Hong-Yi Cao, Liang Wang, Hong-Tao Xu, Qing-Chang Li, Xue-Shan Qiu and En-Hua Wang
    Citation: Diagnostic Pathology 2016 11:73
    Content type: Case Report Published on:

  28. The Nottingham Prognostic Index (NPI), which combines numerical values for nodal status, tumor size and histological grade, is used in the standard of care to provide predictive value information on post-surge...

    Authors: Ginette Serrero, Douglas M. Hawkins, Pablo A. Bejarano, Olga Ioffe, Katherine R. Tkaczuk, Robert E. Elliott, Jonathan F. Head, Jeffrey Phillips, Andrew K. Godwin, JoEllen Weaver, David Hicks and Binbin Yue
    Citation: Diagnostic Pathology 2016 11:71
    Content type: Research Published on:

  30. Cotyledonoid dissecting leiomyoma is a rare variant of uterine smooth muscle tumor with an unusual growth pattern that shows intramural dissection within uterine myometrium and often a placenta-like appearance...

    Authors: Ai Shimizu, Hoshihito Tanaka, Sari Iwasaki, Yukio Wakui, Hitoshi Ikeda and Akira Suzuki
    Citation: Diagnostic Pathology 2016 11:69
    Content type: Case Report Published on:

  31. Increased expression of DEF6 is correlated with the malignant behavior of various cancers. Both DEF6 and p16 contribute to the regulation of cell cycle progression, and p53 plays important role in the cell cyc...

    Authors: Phui-Ly Liew, Chih-Yeu Fang, Yu-Chieh Lee, Yi-Chih Lee, Chi-Long Chen and Jan-Show Chu
    Citation: Diagnostic Pathology 2016 11:68
    Content type: Research Published on:

  32. To explore the clinical characteristics and pathological features of epithelioid inflammatory myofibroblastic sarcoma (EIMS) with emphasis on the diagnostic spectrum.

    Authors: Lin Yu, Jinguo Liu, I Weng Lao, Zhiguo Luo and Jian Wang
    Citation: Diagnostic Pathology 2016 11:67
    Content type: Research Published on:

  33. In East Asia, monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), previously known as type II enteropathy-associated T-cell lymphoma (EATL), occurs more frequently than type I EATL, and coeliac dis...

    Authors: Hideki Ishibashi, Satoshi Nimura, Yoshiyuki Kayashima, Yasushi Takamatsu, Kunihiko Aoyagi, Naohiko Harada, Masanori Kadowaki, Takihiko Kamio, Shotaro Sakisaka and Morishige Takeshita
    Citation: Diagnostic Pathology 2016 11:66
    Content type: Case Report Published on:

  34. Pleomorphic xanthoastrocytoma (PXA) with anaplastic features should be strictly distinguished from glioblastoma multiforme (GBM).

    Authors: Shoko M. Yamada, Hideki Murakami, Yusuke Tomita, Makoto Nakane, Soichiro Shibui, Mikiko Takahashi and Masashi Kawamoto
    Citation: Diagnostic Pathology 2016 11:65
    Content type: Case Report Published on:

  36. Digital image analysis offers advantages over traditional pathologist visual scoring of immunohistochemistry, although few studies examining the correlation and reproducibility of these methods have been perfo...

    Authors: Anthony E. Rizzardi, Xiaotun Zhang, Rachel Isaksson Vogel, Suzanne Kolb, Milan S. Geybels, Yuet-Kin Leung, Jonathan C. Henriksen, Shuk-Mei Ho, Julianna Kwak, Janet L. Stanford and Stephen C. Schmechel
    Citation: Diagnostic Pathology 2016 11:63
    Content type: Research Published on:

  37. Primary pleuropulmonary and mediastinal synovial sarcomas (PPMSSs) are extremely rare. The authors present the largest series in an Asian population.

    Authors: Ting Lan, Huijiao Chen, Bo Xiong, Tingqing Zhou, Ran Peng, Min Chen, Feng Ye, Jin Yao, Xin He, Yaqin Wang and Hongying Zhang
    Citation: Diagnostic Pathology 2016 11:62
    Content type: Research Published on:

  38. Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss of function is frequently detected in advanced colorectal cancer. Its detection is thought to have prognostic significance and it is being co...

    Authors: Emese Irma Ágoston, Tamás Micsik, Balázs Ács, Krisztina Fekete, Oszkár Hahn, Zsolt Baranyai, Kristóf Dede, György Bodoky, Attila Bursics, Janina Kulka, Tibor Krenács, Balázs Győrffy, László Harsányi and A. Marcell Szász
    Citation: Diagnostic Pathology 2016 11:61
    Content type: Research Published on:

  39. The validation of novel diagnostic, prognostic and predictive biomarkers in cancer is crucial for optimizing the choice and efficacy of personalized therapies. The aim of this study was to determine the epider...

    Authors: Li Wang, Huanwen Wu, Lili Wang, Junliang Lu, Huanli Duan, Xuguang Liu and Zhiyong Liang
    Citation: Diagnostic Pathology 2016 11:60
    Content type: Research Published on:

  40. Due to therapeutic implications with regard to both efficiency and safety of chemotherapy agents it is important to differentiate between subtypes of NSCLC. Up to today we experience a continuous reservation r...

    Authors: Christian Biancosino, Marcus Krüger, Ekkehard Vollmer and Lutz Welker
    Citation: Diagnostic Pathology 2016 11:59
    Content type: Research Published on:

  41. The recent discovery of the Merkel cell polyomavirus and its consistent association with Merkel cell carcinoma has drawn attention to the numerous recently discovered polyomaviruses and their possible involvem...

    Authors: Jan Beckervordersandforth, Sreedhar Pujari, Dorit Rennspiess, Ernst Jan M. Speel, Véronique Winnepenninckx, Carlos Diaz, Wolfgang Weyers, Anke Maria Haugg, Anna Kordelia Kurz and Axel zur Hausen
    Citation: Diagnostic Pathology 2016 11:58
    Content type: Research Published on:

  42. Pathological diagnosis of urothelial carcinoma (UC) is primarily based on cytological atypia. It has previously been shown that high-grade (HG) UC, particularly UC in situ cells (CIS), can be over five times t...

    Authors: Kate Poropatich, Jason C. Yang, Rajen Goyal, Vamsi Parini and Ximing J. Yang
    Citation: Diagnostic Pathology 2016 11:57
    Content type: Research Published on:

  43. Embryonal rhabdomyosarcoma of the prostate in an adult is a very rare event with only a few cases published. Diagnosis usually occurs with advanced disease frequently already with metastatic spread. In adults ...

    Authors: Hans-Ulrich Schildhaus, Suvi Lokka, Werner Fenner, Jens Küster, Ingrid Kühnle and Ernst Heinmöller
    Citation: Diagnostic Pathology 2016 11:56
    Content type: Case report Published on:

  44. Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be ap...

    Authors: Felix Behling, Alonso Barrantes-Freer, Marco Skardelly, Maike Nieser, Arne Christians, Florian Stockhammer, Veit Rohde, Marcos Tatagiba, Christian Hartmann, Christine Stadelmann and Jens Schittenhelm
    Citation: Diagnostic Pathology 2016 11:55
    Content type: Research Published on:

  46. The role of human papillomaviruses (HPV) in the development of squamous cell carcinoma (SCC) has been established for anogenital lesions but still remains controversial for carcinomas in other sites. The aim o...

    Authors: Marián Švajdler Jr, Roman Mezencev, Jana Kašpírková, Denisa Kacerovská, Dmitry V. Kazakov, Ondrej Ondič and Michal Michal
    Citation: Diagnostic Pathology 2016 11:53
    Content type: Research Published on:

  48. Mucopolysaccharidosis type IVA (MPS IVA) is an autosomal recessive disease caused by the deficiency of the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS). The purpose of this study was to anal...

    Authors: Latifa Chkioua, Souhir Khedhiri, Hind Hafsi, Oussama Grissa, Hadhami Ben Turkia, Abdelhedi Miled, Sandrine Laradi, Roseline Froissart and Najat Alif
    Citation: Diagnostic Pathology 2016 11:51
    Content type: Research Published on:

  49. The regional lymph node involvement is a major prognostic factor in patients with non-small cell lung cancer (NSCLC) undergoing surgical resection. Disease relapse is common, suggesting that early disseminated...

    Authors: Ane Kongsgaard Rud, Kjetil Boye, Øystein Fodstad, Siri Juell, Lars H. Jørgensen, Steinar Solberg, Åslaug Helland, Odd Terje Brustugun and Gunhild Mari Mælandsmo
    Citation: Diagnostic Pathology 2016 11:50
    Content type: Research Published on:
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Diagnostic Pathology

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