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  1. Intravascular large B-cell lymphoma is a rare and aggressive lymphoma with a dismal prognosis. Synchronous intravascular large B-cell lymphoma involving gastrointestinal stromal tumor has not previously been d...

    Authors: Fen Zhang, Xinlan Luo, Yu Chen and Yanhui Liu
    Citation: Diagnostic Pathology 2015 10:214
    Content type: Case Report Published on:

  3. Regulation of MMP expression by activation of mTOR signalling has been demonstrated for several tumor types, but has thus far not been confirmed in gastric cancer.

    Authors: Jan Bornschein, Tina Seidel, Cosima Langner, Alexander Link, Thomas Wex, Michael Selgrad, Doerthe Jechorek, Frank Meyer, Elizabeth Bird-Lieberman, Michael Vieth and Peter Malfertheiner
    Citation: Diagnostic Pathology 2015 10:212
    Content type: Short report Published on:

  4. Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression o...

    Authors: Yingqiang Xu, Zhonghu Li, Peng Jiang, Guo Wu, Kai Chen, Xi Zhang and Xiaowu Li
    Citation: Diagnostic Pathology 2015 10:211
    Content type: Research Published on:

  5. Thoracic pathologists are frequently faced with tissue specimens from intrathoracic/mediastinal tumors. Specifically the differentiation between thymic and pulmonary squamous cell carcinomas (SqCC) can be chal...

    Authors: Mark Kriegsmann, Thomas Muley, Alexander Harms, Luca Tavernar, Torsten Goldmann, Hendrik Dienemann, Esther Herpel and Arne Warth
    Citation: Diagnostic Pathology 2015 10:210
    Content type: Research Published on:

  6. Warthin tumors presenting concomitantly with a lymphoma is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a mantle cell lymphoma involv...

    Authors: Ramir S. Arcega, Aaron J. Feinstein, Sunita Bhuta, Keith E. Blackwell, Nagesh P. Rao and Sheeja T. Pullarkat
    Citation: Diagnostic Pathology 2015 10:209
    Content type: Case Report Published on:

  7. Hirschsprung’s disease (HD) is an anomaly characterized by the absence of myenteric and submucosal ganglion cells (GC) in the distal alimentary tract. Diagnosis of HD is made by the absence of GC and missing o...

    Authors: R. K. Agrawal, Nandita Kakkar, R. K. Vasishta, Vandana Kumari, R. Samujh and K. L. N. Rao
    Citation: Diagnostic Pathology 2015 10:208
    Content type: Research Published on:

  8. We recently reported one interesting case showing mutation-free c-KIT proto-oncogene overexpression and paradoxical hypermethylation in 54 cases of primary squamous cell carcinoma of uterine cervix (SCC). However...

    Authors: Shih-Wen Chang, Wan-Ru Chao, Alexandra Ruan, Po-Hui Wang, Jau-Chen Lin and Chih-Ping Han
    Citation: Diagnostic Pathology 2015 10:207
    Content type: Hypothesis Published on:

  9. Merkel cell carcinoma (MCC) is a rare but aggressive cutaneous neuroendocrine tumor, which multifactorial etiopathogenesis seems to be related to ultraviolet radiation, Merkel cell polyomavirus (MCV), and immu...

    Authors: Sabin Gligore Turdean, Simona Gurzu, Ioan Jung, Radu Mircea Neagoe and Daniela Sala
    Citation: Diagnostic Pathology 2015 10:206
    Content type: Case Report Published on:

  10. Ossification in the posterior longitudinal ligament (PLL) correlates with changes of enthesis during the early stages of development, but this issue remains controversial, as little is known regarding the deta...

    Authors: Katsunori Fukutake, Takao Ishiwatari, Hiroshi Takahashi, Kazuaki Tsuchiya, Yoichiro Okubo, Minoru Shinozaki, Naobumi Tochigi, Megumi Wakayama, Tetsuo Nemoto, Kazutoshi Shibuya and Akihito Wada
    Citation: Diagnostic Pathology 2015 10:205
    Content type: Research Published on:

  11. Mixed adeno-neuroendocrine carcinoma (MANEC) of the biliary tract is rare with only a few reported cases. Consequently, knowledge about their pathogenesis, histopathological characteristics and outcomes is spa...

    Authors: Sean L. Zheng, Vincent S. Yip, Federica Pedica, Andreas Prachalias and Alberto Quaglia
    Citation: Diagnostic Pathology 2015 10:204
    Content type: Case Report Published on:

  12. We have read the case report of Nihon-Yanagi et al. The patient they described developed hepatic granuloma two times and the granulomatous lesion was surrounding metal staples/clips suggesting that the granulo...

    Authors: Resat Ozaras, Mucahit Yemisen and Ilker Inanc Balkan
    Citation: Diagnostic Pathology 2015 10:203
    Content type: Letter to the Editor Published on:

  14. We have recently reported the presence of the Human polyomavirus 7 (HPyV7) in human thymic epithelial tumors as assessed by diverse molecular techniques. Here we report on the co-expression of p16, retinoblast...

    Authors: Marlies Keijzers, Dorit Rensspiess, Sreedhar Pujari, Myrurgia A. Abdul-Hamid, Monique Hochstenbag, Anne-Marie Dingemans, Anna Kordelia Kurz, Anke Haugg, Jos. G. Maessen, Marc H. De Baets and Axel zur Hausen
    Citation: Diagnostic Pathology 2015 10:201
    Content type: Research Published on:

  15. To evaluate whether tumor invasion depth can be a reliable and easily applicable pathologic assessment strategy to predict outcomes using surgically resected cervical squamous cell carcinoma specimens from pat...

    Authors: Yang Lv, Ning Wang, Yixiong Liu, Xia Li, Linni Fan, Mingyang Li, Lu Wang, Zhou Yu, Qingguo Yan, Ying Guo, Shuangping Guo, Lichun Wei, Mei Shi and Zhe Wang
    Citation: Diagnostic Pathology 2015 10:200
    Content type: Research Published on:

  16. Four cases of tumors in which cell internalization was frequently visualized are reported: one feline mammary carcinoma, one feline cutaneous squamous cell carcinoma, one canine pulmonary squamous cell carcino...

    Authors: Fernando Costa Ferreira, Maria João Soares, Sandra Carvalho, Liliana Borralho, Gonçalo Vicente, Sandra Branco, Jorge Correia and Maria Conceição Peleteiro
    Citation: Diagnostic Pathology 2015 10:199
    Content type: Case Report Published on:

  17. We investigated the mechanism of action of silymarin in a mouse model of renal ischemia–reperfusion injury (I/R) to ascertain its role in the treatment of I/R injury.

    Authors: Jian Tan, Jianpeng Hu, Yonghui He and Feilun Cui
    Citation: Diagnostic Pathology 2015 10:198
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:71

  18. Coexistence of metastasis from squamous cell carcinoma and tuberculosis within lymph nodes is rare. We report a case of 86 years old woman with a mass in the left laterocervical region. The patient had undergo...

    Authors: Danila Caroppo, Daniela Russo, Francesco Merolla, Gennaro Ilardi, Marialaura Del Basso de Caro, PierPaolo Di Lorenzo, Silvia Varricchio, Massimo Mascolo and Stefania Staibano
    Citation: Diagnostic Pathology 2015 10:197
    Content type: Case Report Published on:

  19. Nodular follicular lesions of thyroid gland comprise benign and malignant neoplasms, as well as some forms of hyperplasia. “Follicular” refers to origin of cells and in the same time to growth pattern - buildi...

    Authors: Duško Dunđerović, Jasmina Marković Lipkovski, Ivan Boričic, Ivan Soldatović, Vesna Božic, Dubravka Cvejić and Svetislav Tatić
    Citation: Diagnostic Pathology 2015 10:196
    Content type: Research Published on:

  20. Melanoma is a skin cancer which treatment requires early diagnosis and large surgical removal. The histopathological diagnosis of a melanocytic tumour is sometimes difficult between a benign nevus and a malign...

    Authors: Arnaud Uguen, Matthieu Talagas, Sebastian Costa, Sandrine Duigou, Stéphanie Bouvier, Marc De Braekeleer and Pascale Marcorelles
    Citation: Diagnostic Pathology 2015 10:195
    Content type: Research Published on:

  22. A 72-year-old male presented with urinary symptoms. His serum prostate specific antigen level was 65.2 ng/ml. His radical prostatectomy specimen showed clear cell lesion reminiscent of the clear cell renal cel...

    Authors: Shashikant C. U. Patne, Nidhi Johri, Richa Katiyar, Sameer Trivedi and Uday Shankar Dwivedi
    Citation: Diagnostic Pathology 2015 10:193
    Content type: Case Report Published on:

  23. Family with sequence similarity 3, member C (FAM3C) has been identified as a novel regulator in epithelial-mesenchymal transition (EMT) and metastatic progression. However, the role of FAM3C in esophageal squa...

    Authors: Ying-Hui Zhu, Baozhu Zhang, Mengqing Li, Pinzhu Huang, Jian Sun, Jianhua Fu and Xin-Yuan Guan
    Citation: Diagnostic Pathology 2015 10:192
    Content type: Research Published on:

  24. Flow cytometric immunophenotyping (FCI), is widely used in cytology for distinguishing between B-cell lymphoma (BCL) and reactive lymphocytic proliferations (RLP), mainly by identifying monotypic B-cell popula...

    Authors: Andreja Brozic, Ziva Pohar Marinsek, Srdjan Novakovic and Veronika Kloboves Prevodnik
    Citation: Diagnostic Pathology 2015 10:191
    Content type: Research Published on:

  26. PD-L1 is a glycoprotein from the family of T-cell co-stimulatory molecules that are constitutively expressed by macrophages. Aberrant expression of PD-L1 is observed in human cancers associated with inhibition...

    Authors: Katia R M Leite, Sabrina T. Reis, José Pontes Junior, Marcelo Zerati, Daniel de Oliveira Gomes, Luiz H. Camara-Lopes and Miguel Srougi
    Citation: Diagnostic Pathology 2015 10:189
    Content type: Research Published on:

  27. Zygomycetes cause different patterns of infection in immunosuppressed individuals, including sino-orbito-cerebral, pulmonary, skin/soft tissue infection and disseminated disease. Infections with Zygomycetes ha...

    Authors: Nives Zimmermann, Matthew C Hagen, Jason J Schrager, Renee S Hebbeler-Clark and Sreeharsha Masineni
    Citation: Diagnostic Pathology 2015 10:188
    Content type: Research Published on:

  28. The transcriptional co-activator, TAZ, is an important effector of the Hippo pathway and is critical for the development of human cancers. However, the expression and prognostic significance of TAZ in retinobl...

    Authors: Yiting Zhang, Chunyan Xue, Hongjuan Cui and Zhenping Huang
    Citation: Diagnostic Pathology 2015 10:187
    Content type: Research Published on:

  29. The authors present two cases of primary sclerosing epithelioid fibrosarcoma (SEF) of the kidney. Both patients had a mass in the upper part of the left kidney without any primary extrarenal neoplastic lesions...

    Authors: Dilek Ertoy Baydar, Kemal Kosemehmetoglu, Oguz Aydin, Julia A. Bridge, Berrin Buyukeren and Fazil Tuncay Aki
    Citation: Diagnostic Pathology 2015 10:186
    Content type: Case Report Published on:

  30. Malignant syphilis or lues maligna is a severe form of secondary syphilis that was commonly reported in the pre-antibiotic era, and has now reemerged with the advent of the human immunodeficiency virus (HIV) e...

    Authors: Michiko Yamashita, Yoshiyuki Fujii, Keiji Ozaki, Yoshio Urano, Masami Iwasa, Shingen Nakamura, Shiro Fujii, Masahiro Abe, Yasuharu Sato and Tadashi Yoshino
    Citation: Diagnostic Pathology 2015 10:185
    Content type: Case Report Published on:

  31. Osteosarcoma (OS) is a primary malignant bone tumor with high morbidity that principally emerges in children and adolescents. MiRNAs regulate a variety of normal physiologic processes and are involved in tumor...

    Authors: Afshin Taheriazam, Amir Jouya Talaei, Mohammad Jamshidi, Mohammadreza Shakeri, Samaneh Khoshbakht, Emad Yahaghi and Marjan Shokrani
    Citation: Diagnostic Pathology 2015 10:184
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:112

  32. Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old ...

    Authors: Takuro Igawa, Yasuharu Sato, Hotaka Kawai, Eisei Kondo, Mai Takeuchi, Tomoko Miyata-Takata, Katsuyoshi Takata and Tadashi Yoshino
    Citation: Diagnostic Pathology 2015 10:183
    Content type: Case Report Published on:

  34. Collision tumors of the stomach are rare. We report on a case of a collision tumor consisting of a gastrointestinal stromal tumor (GIST) and an inflammatory myofibroblastic tumor (IMT) of the stomach in a 16-y...

    Authors: Hyeong Chan Shin, Mi Jin Gu, Se Won Kim, Jae Woon Kim and Joon Hyuk Choi
    Citation: Diagnostic Pathology 2015 10:181
    Content type: Case Report Published on:

  35. A 51-year-old female underwent vitrectomy surgery to remove a group of spherical subretinal tumors beneath the detached retina. Hematoxylin and eosin staining and immunohistochemical findings showed that the c...

    Authors: Ting Zhang, Hong Lin, Zhanyu Zhou, Nianting Tong, Ying Li, Yu Zhang, Liangyu Wang and Fuling Liu
    Citation: Diagnostic Pathology 2015 10:180
    Content type: Case Report Published on:

  36. Xp11.2 or TFE3 translocation renal cell carcinomas (RCC) and alveolar soft part sarcoma (ASPS) are characterized by chromosome translocations involving the Xp11.2 breakpoint resulting in transcription factor T...

    Authors: Dinesh Pradhan, Somak Roy, Gabriela Quiroga-Garza, Kathleen Cieply, Alyssa L. Mahaffey, Sheldon Bastacky, Rajiv Dhir and Anil V. Parwani
    Citation: Diagnostic Pathology 2015 10:179
    Content type: Research Published on:

  37. MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated to clarify the clinicopathological significance and prognostic value of miR-124 in breas...

    Authors: Ali Arabkheradmand, Aghdas Safari, Mehri Seifoleslami, Emad Yahaghi and Masoumeh Gity
    Citation: Diagnostic Pathology 2015 10:178
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:122

  38. Multiple protein or microRNA markers have been recognized to contribute to the progression and recurrence of cervical cancers. Particular those, which are associated with the chemo- or radio-resistance of cerv...

    Authors: Xiang-Rong Shu, Jing Wu, He Sun, Li-Qun Chi and Jin-Huan Wang
    Citation: Diagnostic Pathology 2015 10:177
    Content type: Research Published on:

  39. To investigate the relationship of KAI1/CD82, CD44, matrix metalloproteinase 7 (MMP7) and β-catenin, and examine its association with clinicopathological features, metastasis and prognosis in colorectal carcin...

    Authors: Qiong Wu, Yan Yang, Shiwu Wu, Wanyun Li, Na Zhang, Xiuqin Dong and Yurong Ou
    Citation: Diagnostic Pathology 2015 10:176
    Content type: Research Published on:

  40. p16 expression is a well established biomarker of cervical dysplasia and carcinoma arising from high risk human papilloma virus infection. Increased p16 expression is also seen in squamous neoplasms arising at...

    Authors: Peter J. Kobalka, Jean-Paul Abboud, Xiaoyan Liao, Karra Jones, Bradford W. Lee, Bobby S. Korn, Don O. Kikkawa and Jonathan H. Lin
    Citation: Diagnostic Pathology 2015 10:175
    Content type: Research Published on:

  41. Primary systemic amyloidosis (PSA) is one of systemic amyloidosis, characterized by clonal plasma cell disorder. The disease is rare and with high fatality. Signs and symptoms of PSA are various and complex, w...

    Authors: Xiu Lin, Yueping Mao, Qing Qi, Chuyi Zhang, Yongzhen Tian and Yanyang Chen
    Citation: Diagnostic Pathology 2015 10:174
    Content type: Case Report Published on:

  43. Tumor-to-tumor metastasis is a rare phenomenon, but it has been suggested to be more frequent in patients with hereditary cancer syndrome. We report an autopsy case of tumor-to-tumor metastasis in a 75-year-ol...

    Authors: Karen Matsumoto, Kanae Nosaka, Tatsushi Shiomi, Yuki Matsuoka and Yoshihisa Umekita
    Citation: Diagnostic Pathology 2015 10:172
    Content type: Case Report Published on:

  44. Central neurocytoma/extraventricular neurocytoma is a central nervous system (CNS) tumor composed of uniform round cells with neuronal differentiation. The typical lesions of central neurocytoma/extraventricul...

    Authors: Juan-Han Yu, Lian-He Yang, Xu-Yong Lin, Shun-Dong Dai, Xue-Shan Qiu and En-Hua Wang
    Citation: Diagnostic Pathology 2015 10:171
    Content type: Case Report Published on:

  45. Nasopharyngeal carcinoma (NPC) is an EBV-associated malignant tumor of nasopharynx. As extremely rare condition, the second primary cancer of nasopharynx can occur in NPC patients synchronously or subsequently...

    Authors: Ri-chang Du, Hai-nan Li, Wei Huang, Xiao-ying Tian and Zhi Li
    Citation: Diagnostic Pathology 2015 10:170
    Content type: Case Report Published on:

  47. Trichorhinophalangeal syndrome 1 (Trps1) gene is a member of GATA transcription factor family and has an important function in tumorigenesis and progression. However, there are rare studies on its roles in car...

    Authors: Zhishuang Li, Ming Jia, Xiaojuan Wu, Jingjing Cui, Aifeng Pan and Li Li
    Citation: Diagnostic Pathology 2015 10:167
    Content type: Research Published on:

  48. Lung cancer is most common and is the leading cause of cancer-related death in both men and women worldwide. Understanding of the molecular mechanisms underlying non-small cell lung cancer (NSCLC) development ...

    Authors: Naeemeh Ghasemkhani, Sahar Shadvar, Yasamin Masoudi, Amir Jouya Talaei, Emad Yahaghi, Peyman Karimi Goudarzi and Ebrahim Shakiba
    Citation: Diagnostic Pathology 2015 10:164
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:110

  49. The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of ...

    Authors: Szofia Hajósi-Kalcakosz, Eszter Vincze, Katalin Dezső, Sándor Paku, András Rókusz, Zoltán Sápi, Erika Tóth and Péter Nagy
    Citation: Diagnostic Pathology 2015 10:163
    Content type: Research Published on:

  50. Granular cell tumors (GCTs) were firstly described by Weber in 1854 and 70 years later by Abrikossoff and classified as benign tumors. Originally considered muscle tumors, they have been identified as neural l...

    Authors: Natale Porta, Riccardo Mazzitelli, Jessica Cacciotti, Mirko Cirenza, Agata Labate, Maria Grazia Lo Schiavo, Andrea Laghi, Vincenzo Petrozza and Carlo Della Rocca
    Citation: Diagnostic Pathology 2015 10:162
    Content type: Case Report Published on:
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Diagnostic Pathology

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