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  1. Ectopic liver is a very uncommon developmental anomaly that predisposes to the development of hepatocellular carcinoma. We describe the second documented case of a hepatocellular carcinoma developing in the pr...

    Authors: Matthias Dettmer, Peter Itin, Peter Miny, Manoj Gandhi, Gieri Cathomas and Niels Willi
    Citation: Diagnostic Pathology 2011 6:75
    Content type: Case Report Published on:

  3. Cancer stem cell (CSC) hypothesis postulates that tumors are maintained by a self-renewing CSC population that is also capable of differentiating into non-self-renewing cell populations that constitute the bul...

    Authors: João Paulo Oliveira-Costa, Juliana S Zanetti, Giórgia G Silveira, Danilo F Soave, Lucinei R Oliveira, Verônica A Zorgetto, Fernando A Soares, Sérgio Zucoloto and Alfredo Ribeiro-Silva
    Citation: Diagnostic Pathology 2011 6:73
    Content type: Research Published on:

  4. Aortic valve replacement (AVR) is the gold standard for the treatment of severe symptomatic aortic stenosis. Complications directly related to surgical procedure are relatively infrequent. Coronary ostial sten...

    Authors: Emanuela Turillazzi, Gabriele Di Giammarco, Margherita Neri, Stefania Bello, Irene Riezzo and Vittorio Fineschi
    Citation: Diagnostic Pathology 2011 6:72
    Content type: Case Report Published on:

  5. Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide ...

    Authors: Guillermo Muñoz, Francesc Felipo, Isabel Marquina and Celia Del Agua
    Citation: Diagnostic Pathology 2011 6:71
    Content type: Case Report Published on:

  6. Epstein Barr Virus (EBV) plays a significant role as a cofactor in the process of tumorigenesis and has consistently been associated with a variety of malignancies. EBV encoded RNAs (EBER1 and EBER2) are the m...

    Authors: Taimoor I Sheikh and Ishtiaq Qadri
    Citation: Diagnostic Pathology 2011 6:70
    Content type: Methodology Published on:

  7. Lipoid proteinosis is a rare autosomal recessive disease characterized by cutaneous and mucosal lesions and hoarseness appearing in early childhood that is caused by homozygous or compound heterozygous mutatio...

    Authors: Muhammad Nasir, Amir Latif, Muhammad Ajmal, Reem Qamar, Muhammad Naeem and Abdul Hameed
    Citation: Diagnostic Pathology 2011 6:69
    Content type: Research Published on:

  8. To analyze the hypothesis of events or neighborhood interactions that is based upon recognizable structures of systems which possess a surface in a four dimensional space - time constellation {x, y, z, t}. To ...

    Authors: Klaus Kayser, Stephan Borkenfeld, Torsten Goldmann and Gian Kayser
    Citation: Diagnostic Pathology 2011 6:68
    Content type: Hypothesis Published on:

  9. Distinguishing urothelial carcinoma (UC) from prostate carcinoma (PC) is important due to potential therapeutic and prognostic implications. However, this can be a diagnostic challenge when there is limited ti...

    Authors: Malini Srinivasan and Anil V Parwani
    Citation: Diagnostic Pathology 2011 6:67
    Content type: Research Published on:

  11. Primary angiosarcoma of the ovary (AS) is a rare entity with only 31 reported cases. The majority are pure angiosarcomas, the remainder are associated either with teratomas or conventional epithelial tumors. M...

    Authors: Hans Bösmüller, Christine Gruber, Sophie Haitchi-Petnehazy, Dietmar Wagner, Gerald Webersinke and Steffen Hauptmann
    Citation: Diagnostic Pathology 2011 6:65
    Content type: Case Report Published on:

  13. Amongst follicular lymphoma that transforms into a high-grade lymphoma, majority are diffuse large B cell lymphoma. Here we reported a rare atypical Burkitt's lymphoma transformation from an asymptomatic folli...

    Authors: Yu Y Hwang, Florence Loong, Lap P Chung and Chor S Chim
    Citation: Diagnostic Pathology 2011 6:63
    Content type: Case Report Published on:

  15. Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic tar...

    Authors: Mojgan Asgari and Arman Morakabati
    Citation: Diagnostic Pathology 2011 6:61
    Content type: Research Published on:

  16. We recently encountered an unusual case of Composite lymphoma (CL) in the anterior mediastinum arising in a 37-year-old woman who presented initially with continuous pain in the right shoulder and chest. The w...

    Authors: Guohua Yu, Lingling Kong, Guimei Qu, Qian Zhang, Wei Wang and Lei Jiang
    Citation: Diagnostic Pathology 2011 6:60
    Content type: Case Report Published on:

  17. D2-40 has been shown a selective marker for lymphatic endothelium, but also shown in the benign cervical basal cells. However, the application of D2-40 immunoreactivity in the cervical basal cells for identify...

    Authors: Hongxiu Han, Yan Yang, Zhouping Lu, Qizhi He and Zhenhua Lin
    Citation: Diagnostic Pathology 2011 6:59
    Content type: Research Published on:

  19. Breast cancers which demonstrate EGFR protein expression, gene amplification and/or gene mutations may benefit therapeutically from tyrosine kinase inhibitors. In Western studies, EGFR protein expression has b...

    Authors: Mohamed A Shawarby, Dalal M Al-Tamimi and Ayesha Ahmed
    Citation: Diagnostic Pathology 2011 6:57
    Content type: Short report Published on:

  20. Endocervicosis in the urinary bladder is a rare benign condition. We present a case in a 37-year-old woman with classical clinical and pathological features of endocervicosis. The unusual observation of endoce...

    Authors: Phaik-Leng Cheah, Lai-Meng Looi, George Eng-Geap Lee, Kean-Hooi Teoh, Kein-Seong Mun and Abdul Rahman Nazarina
    Citation: Diagnostic Pathology 2011 6:56
    Content type: Case Report Published on:

  22. The development of inhibitors against factor 8 (F8) is the most serious complication of replacement therapy with F8 in children with severe hemophilia. It was suggested that mismatched F8 replacement therapy m...

    Authors: Hejer Elmahmoudi, Nejla Belhedi, Asma Jlizi, Kaouther Zahra, Balkis Meddeb, Amel Ben Ammar Elgaaied and Emna Gouider
    Citation: Diagnostic Pathology 2011 6:54
    Content type: Short report Published on:

  23. The recent introduction of bronchoscopically recovered cryobiopsy of lung tissue has opened up new possibilities in the diagnosis of neoplastic and non-neoplastic lung diseases in various aspects. Most notably...

    Authors: Sergej Griff, Wim Ammenwerth, Nicolas Schönfeld, Torsten T Bauer, Thomas Mairinger, Torsten-Gerriet Blum, Jens Kollmeier and Wolfram Grüning
    Citation: Diagnostic Pathology 2011 6:53
    Content type: Research Published on:

    The Erratum to this article has been published in Diagnostic Pathology 2016 11:64

  24. Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal tract usually occurring in the 6th to 7th decade of life, while their occurrence in children is rare (1-2%)...

    Authors: Claudia Otto, Abbas Agaimy, Alexander Braun, Jochen Rädecke, Jens Hoeppner, Gerald Illerhaus, Martin Werner, Udo Kontny and Florian Haller
    Citation: Diagnostic Pathology 2011 6:52
    Content type: Case Report Published on:

  26. Undifferentiated connective tissue diseases (UCTDs) are clinical entities characterised by signs and symptoms suggestive of a systemic autoimmune disease, which do not fulfil the diagnostic criteria for a defi...

    Authors: Francesca Lunardi, Elisabetta Balestro, Beatrice Nordio, Franco Cozzi, Roberta Polverosi, Paolo Sfriso, Fausto Braccioni and Fiorella Calabrese
    Citation: Diagnostic Pathology 2011 6:50
    Content type: Case Report Published on:

  27. It's well recognized that X-linked inhibitor of apoptosis (XIAP) was the most potent caspase inhibitor and second mitochondria-derived activator of caspase (Smac) was the antagonist of XIAP. Experiments in vit...

    Authors: Yutao Zhang, Jianhua Zhu, Yun Tang, Feng Li, Hongyuan Zhou, Bofang Peng, Chifeng Zhou and Rong Fu
    Citation: Diagnostic Pathology 2011 6:49
    Content type: Research Published on:

  28. Lung cancer is a major cause of death worldwide. Gene promoter methylation is a major inactivation mechanism of tumor-related genes, some of which can be served as a biomarker for early diagnosis and prognosis...

    Authors: Meiju Ji, Yong Zhang, Bingyin Shi and Peng Hou
    Citation: Diagnostic Pathology 2011 6:48
    Content type: Research Published on:

  29. Mucopolysaccharidosis type I (MPS I) is an autosomal storage disease resulting from defective activity of the enzyme α-L-iduronidase (IDUA). This glycosidase is involved in the degradation of heparan sulfate a...

    Authors: Latifa Chkioua, Souhir Khedhiri, Hadhami Ben Turkia, Rémy Tcheng, Roseline Froissart, Henda Chahed, Salima Ferchichi, Marie Françoise Ben Dridi, Christine Vianey-Saban, Sandrine Laradi and Abdelhedi Miled
    Citation: Diagnostic Pathology 2011 6:47
    Content type: Research Published on:

  31. A case of single breast metastasis from colon adenocarcinoma, with omolateral axillary micrometastasis, is reported with a brief review of the pertinent literature. The originality of the oncological concept o...

    Authors: Tiziana Perin, Vincenzo Canzonieri, Lorenzo Memeo and Samuele Massarut
    Citation: Diagnostic Pathology 2011 6:45
    Content type: Case Report Published on:

  33. Histological malignancy grading of astrocytomas can be challenging despite criteria given by the World Health Organisation (WHO). Grading is fundamental for optimal prognostication and treatment, and additiona...

    Authors: Andreas H Habberstad, Sasha Gulati and Sverre H Torp
    Citation: Diagnostic Pathology 2011 6:43
    Content type: Research Published on:

  34. Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is X-linked recessive lysosomal storage disorder resulting from the defective activity of the enzyme iduronate-2-sulfatase (IDS). Hunter disease can vary...

    Authors: Latifa Chkioua, Souhir Khedhiri, Salima Ferchichi, Rémy Tcheng, Henda Chahed, Roseline Froissart, Christine Vianey-Saban, Sandrine Laradi and Abdelhedi Miled
    Citation: Diagnostic Pathology 2011 6:42
    Content type: Case Report Published on:

  35. Pulmonary sclerosing hemangiomas (PSH) of the lung are uncommon tumors and may present cytological atypia with unusual manifestations. The development of PSH combined with other different tumors in lung is ext...

    Authors: Wei Liu, Xiao-Ying Tian, Yang Li, Yong Zhao, Bin Li and Zhi Li
    Citation: Diagnostic Pathology 2011 6:41
    Content type: Case Report Published on:

  37. Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder caused by a genetic defect in alpha-L-iduronidase (IDUA) which is involved in the degradation of dermatan and heparan s...

    Authors: Latifa Chkioua, Souhir Khedhiri, Asma Kassab, Amina Bibi, Salima Ferchichi, Roseline Froissart, Christine Vianey-Saban, Sandrine Laradi and Abdelhedi Miled
    Citation: Diagnostic Pathology 2011 6:39
    Content type: Research Published on:

  38. We report a 32-year-old woman (1-gravid, 1-para) with a vesicular lesion in her uterus that was pointed out on ultrasound at 8 weeks' gestation. Amniocentesis at 15 weeks' gestation showed a normal female kary...

    Authors: Takeshi Umazume, Soromon Kataoka, Kyouko Kamamuta, Fumie Tanuma, Akihiko Sumie, Toru Shirogane, Takayuki Kudou and Hitoshi Ikeda
    Citation: Diagnostic Pathology 2011 6:38
    Content type: Case Report Published on:

  39. There is a well-documented relationship between urinary bladder diverticula and intradiverticular neoplasms. The great majorities of these tumors are urothelial carcinomas, but may also be of glandular or squa...

    Authors: Igor Grubišić, Tanja Leniček, Davor Tomas, Tihana Džombeta, Davor Trnski, Igor Tomašković and Božo Krušlin
    Citation: Diagnostic Pathology 2011 6:37
    Content type: Case Report Published on:

  40. Maspin is a unique member of the serine protease inhibitor superfamily and its expression is found in myoepithelial cells of normal mammary glands; therefore, it has been considered to be a myoepithelial marke...

    Authors: Yoshihisa Umekita, Yasuyo Ohi, Masakazu Souda, Yoshiaki Rai, Yoshiaki Sagara, Yasuaki Sagara, Shugo Tamada and Akihide Tanimoto
    Citation: Diagnostic Pathology 2011 6:36
    Content type: Short report Published on:

  41. A case of malignant mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described. The primary pedunculated tumor measuring 14 × ...

    Authors: Yao-Feng Li, Cheng-Ping Yu, Seng-Tang Wu, Ming-Shen Dai and Herng-Sheng Lee
    Citation: Diagnostic Pathology 2011 6:35
    Content type: Case Report Published on:

  42. Nowadays, the histological examination of prostate core needle biopsies is still regarded as the gold standard in the diagnosis of prostate cancer (PCa). We investigated if the tissue print of core needle biop...

    Authors: Adriano Angelucci, Gianna Pace, Patrizia Sanità, Carlo Vicentini and Mauro Bologna
    Citation: Diagnostic Pathology 2011 6:34
    Content type: Research Published on:

  43. In our recent study, we determined the cut-off value of CD20 expression at the level of 25 000 molecules of equivalent soluble fluorochrome (MESF) to be the predictor of response to rituximab containing treatm...

    Authors: Veronika Kloboves Prevodnik, Jaka Lavrenčak, Mateja Horvat and Barbara Jezeršek Novakovič
    Citation: Diagnostic Pathology 2011 6:33
    Content type: Research Published on:

  45. The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed t...

    Authors: Rodolfo Montironi, Liang Cheng, Marina Scarpelli, Roberta Mazzucchelli and Antonio Lopez-Beltran
    Citation: Diagnostic Pathology 2011 6:31
    Content type: Commentary Published on:

  46. To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas.

    Authors: Tetuo Mikami, Tsutomu Yoshida, Yoshiko Numata, Masaomi Kikuchi, Kayo Araki, Norihiro Nakada and Isao Okayasu
    Citation: Diagnostic Pathology 2011 6:30
    Content type: Research Published on:

  47. Mucocele-like lesions (MLL) of the breast were originally described as benign lesions composed of multiple cysts lined by uniform flat to cuboidal epithelium with extravasated mucin, but subsequent reports des...

    Authors: Yasuyo Ohi, Yoshihisa Umekita, Yoshiaki Rai, Yasuaki Sagara, Shinichi Baba, Shugo Tamada, Yoshiaki Sagara, Taeko Kukita, Takako Yoshioka, Kazuhito Hatanaka, Yoshiatsu Sagara and Akihide Tanimoto
    Citation: Diagnostic Pathology 2011 6:29
    Content type: Short report Published on:

  48. In Idiopathic pulmonary fibrosis (IPF) irreversibly progressive fibrosing parenchymal damage, leads to defects in mechanics and gas exchange, manifesting with disabling exertional dyspnea. Previous studies hav...

    Authors: Christina Triantafillidou, Effrosyni D Manali, Christina Magkou, Christina Sotiropoulou, Likurgos F Kolilekas, Konstantinos Kagouridis, Dimitra Rontogianni and Spyros A Papiris
    Citation: Diagnostic Pathology 2011 6:28
    Content type: Research Published on:

  49. Digital pathology, i.e., applications of digital information technologies to pathology practice, has been expanding in the recent decades and the mode of pathology diagnostic practice is changing with enhanced...

    Authors: Yasunari Tsuchihashi
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S19
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  50. Automated image analysis on virtual slides is evolving rapidly and will play an important role in the future of digital pathology. Due to the image size, the computational cost of processing whole slide images...

    Authors: Norman Zerbe, Peter Hufnagl and Karsten Schlüns
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S16
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

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