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  1. Pulmonary tumor thrombotic microangiopathy (PTTM) has been known as a rare and serious cancer-related pulmonary complication. However, the pathogenesis and pathophysiology of this debilitating condition still ...

    Authors: Yoichiro Okubo, Megumi Wakayama, Kanako Kitahara, Tetsuo Nemoto, Tomoyuki Yokose, Fumihito Abe, Nobuyuki Hiruta, Daisuke Sasai, Minoru Shinozaki, Haruo Nakayama, Takao Ishiwatari and Kazutoshi Shibuya
    Citation: Diagnostic Pathology 2011 6:27
    Content type: Research Published on:

  3. In recent years, a number of technological advancements started to modify the long standing appearance and functionalities of traditional optical microscopes used in Pathology and other medical fields. In fact...

    Authors: Donatella Intersimone, Viviana Snoj, Franca Riosa, Nicola Bortolotti, Sandi Sverko, Carlo A Beltrami and Vincenzo Della Mea
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S25
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  4. As a special function of Virtual Slide (VS) for thick specimens like cytology slides, multilayer (Z-stack) simulated focus and focus fusion were introduced. From the standpoint of surgical pathologist, the opt...

    Authors: Ichiro Mori, Takashi Ozaki, Emiko Taniguchi and Kennichi Kakudo
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S24
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  5. The only realistic way to improve harmonisation of European pathology training is to define the generally accepted competencies and to test them periodically during the training programme (progress test). The ...

    Authors: Jan G van den Tweel and Fred T Bosman
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S23
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  6. Virtual microscopy can improve the workflow of modern pathology laboratories, a goal limited by the large size of the virtual slides (VS). Lately, determination of the Regions of Interest has shown to be usefu...

    Authors: David Romo, Eduardo Romero and Fabio González
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S22
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  7. Fluorescence in situ hybridization (FISH) is very accurate method for measuring HER2 gene copies, as a sign of potential breast cancer. This method requires small tissue samples, and has a high sensitivity to det...

    Authors: Branimir Reljin, Milorad Paskas, Irini Reljin and Korski Konstanty
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S21
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  8. The rationale for choosing a remote quantitative method supporting a diagnostic decision requires some empirical studies and knowledge on scenarios including valid telepathology standards. The tumours of the c...

    Authors: Janina Słodkowska, Tomasz Markiewicz, Bartłomiej Grala, Wojciech Kozłowski, Wielisław Papierz, Katarzyna Pleskacz and Piotr Murawski
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S20
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  9. The Matlab software is a one of the most advanced development tool for application in engineering practice. From our point of view the most important is the image processing toolbox, offering many built-in fun...

    Authors: Tomasz Markiewicz
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S18
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  10. Collaborative Digital Anatomic Pathology refers to the use of information technology that supports the creation and sharing or exchange of information, including data and images, during the complex workflow pe...

    Authors: Christel Daniel, François Macary, Marcial García Rojo, Jacques Klossa, Arvydas Laurinavičius, Bruce A Beckwith and Vincenzo Della Mea PhD
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S17
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  12. There are many scanners of glass slides on the market now. Quality of digital images produced by them may be different and pathologists who examine virtual slides on a monitor may subjectively evaluate it. How...

    Authors: Slawomir Walkowski and Janusz Szymas
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S14
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  13. We describe development and evaluation of the user-friendly web based virtual microscopy - WebMicroscope for teaching and learning dental students basic and oral pathology. Traditional students microscopes wer...

    Authors: Janusz Szymas and Mikael Lundin
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S13
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  14. Diagnostic surgical pathology or tissue–based diagnosis still remains the most reliable and specific diagnostic medical procedure. The development of whole slide scanners permits the creation of virtual slides...

    Authors: Klaus Kayser, Jürgen Görtler, Stephan Borkenfeld and Gian Kayser
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S12
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  15. E–education or electronically transferred continuous education in pathology is one major application of virtual microscopy. The basic conditions and properties of acoustic and visual information transfer, of t...

    Authors: Klaus Kayser, Robert Ogilvie, Stephan Borkenfeld and Gian Kayser
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S11
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  16. Virtual microscopy can be applied in an interactive and an automated manner. Interactive application is performed in close association to conventional microscopy. It includes image standardization suitable to ...

    Authors: Klaus Kayser, Jürgen Görtler, Stephan Borkenfeld and Gian Kayser
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S10
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  17. The distribution of diagnosis-associated information in histological slides is often spatial dependent. A reliable selection of the slide areas containing the most significant information to deriving the assoc...

    Authors: Klaus Kayser, Jürgen Görtler, Stephan Borkenfeld and Gian Kayser
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  18. Virtual microscopy is being introduced in medical education as an approach for learning how to interpret information in microscopic specimens. It is, however, far from evident how to incorporate its use into e...

    Authors: Laura Helle, Markus Nivala, Pauliina Kronqvist, Andreas Gegenfurtner, Pasi Björk and Roger Säljö
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  19. Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize it...

    Authors: S Fasanella, E Leonardi, C Cantaloni, C Eccher, I Bazzanella, D Aldovini, E Bragantini, L Morelli, LV Cuorvo, A Ferro, F Gasperetti, G Berlanda, P Dalla Palma and M Barbareschi
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  20. Digital pathology includes the information technology that allows for the management of information, including data and images, generated in an anatomic pathology department.

    Authors: Marcial García Rojo, Ana Morillo Castro and Luis Gonçalves
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  21. Complement C4d component deposition in kidney allograft biopsies is an established marker of antibody-mediated rejection. In the Banff 07 classification of renal allograft pathology, semi-quantitative evaluati...

    Authors: Ernesta Brazdziute and Arvydas Laurinavicius
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S5
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  22. Starting with the paradigm change of health systems towards personalized health services, the paper introduces the technical paradigms to be met for enabling ubiquitous pHealth including ePathology. The system...

    Authors: Bernd Blobel
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  23. An original strategy is presented, combining stereological sampling methods based on test grids and data reduction methods based on diffusion maps, in order to build a knowledge image database with no bias int...

    Authors: Philippe Belhomme, Myriam Oger, Jean-Jaques Michels, Benoit Plancoulaine and Paulette Herlin
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  24. This study is an initial investigation on the capability of multispectral imaging to capture subtle spectral information that would enable the automatic delineation between the eosinophilic esophagitis and oth...

    Authors: Pinky A Bautista and Yukako Yagi
    Citation: Diagnostic Pathology 2011 6(Suppl 1):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  26. This paper introduces a supervised learning method for finding diagnostic regions of interest in histopathological images. The method is based on the cognitive process of visual selection of relevant regions t...

    Authors: Ricardo Gutiérrez, Francisco Gómez, Lucía Roa-Peña and Eduardo Romero
    Citation: Diagnostic Pathology 2011 6:26
    Content type: Research Published on:

  27. It is difficult to predict survival in patients with idiopathic pulmonary fibrosis. Recently, several proteins, such as surfactant protein (SP) and KL-6, have been reported to be useful biologic markers for pr...

    Authors: Nobuhiko Nagata, Yasuhiko Kitasato, Kentaro Wakamatsu, Masaharu Kawabata, Kazuo Fukushima, Akira Kajiki, Yoshinari Kitahara and Kentaro Watanabe
    Citation: Diagnostic Pathology 2011 6:25
    Content type: Research Published on:

  28. Simple intratesticular cysts are being reported more commonly due to the wider use of scrotal ultrasonography however, their management remains unclear. Treatment has included enucleation, radical orchidectomy...

    Authors: Talal Al-Jabri, Saumya Misra, Zeshaan N Maan, Khalid Khan, Charles Coker and Phil Thompson
    Citation: Diagnostic Pathology 2011 6:24
    Content type: Research Published on:

  29. In recent years, a battery-powered bone marrow biopsy system was developed and cleared by the U.S. Food and Drug Administration to allow health care providers to access the bone marrow space quickly and effici...

    Authors: James R Berenson, Ori Yellin, Brent Blumenstein, Deanna Bojanower, Jonathan Croopnick, David Aboulafia, Gargi Upadhyaya and Cathy Spadaccini
    Citation: Diagnostic Pathology 2011 6:23
    Content type: Research Published on:

  30. Lung cancer diagnosis in tissue material with commonly used histological techniques is sometimes inconvenient and in a number of cases leads to ambiguous conclusions. Frequently advanced immunostaining techniq...

    Authors: Piotr Waloszczyk, Tomasz Janus, Jacek Alchimowicz, Tomasz Grodzki and Krzysztof Borowiak
    Citation: Diagnostic Pathology 2011 6:22
    Content type: Research Published on:

  33. Characterization of novel fusion genes in acute leukemia is important for gaining information about leukemia genesis. We describe the characterization of a new ETV6 fusion gene in acute myeloid leukemia (AML) FAB...

    Authors: Johanna M Kralik, Wolfgang Kranewitter, Hans Boesmueller, Renate Marschon, Gertraud Tschurtschenthaler, Holger Rumpold, Kurt Wiesinger, Martin Erdel, Andreas L Petzer and Gerald Webersinke
    Citation: Diagnostic Pathology 2011 6:19
    Content type: Research Published on:

  34. While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult tre...

    Authors: Sibel Yenidunya, Reyhan Bayrak and Hacer Haltas
    Citation: Diagnostic Pathology 2011 6:18
    Content type: Research Published on:

  36. Ectopic livers are infrequently reported in the literature. The reported size for ectopic livers range from a few millimeters up to several centimeters. They are often clinically silent and incidentally discov...

    Authors: Matthias Dettmer, Gieri Cathomas and Niels Willi
    Citation: Diagnostic Pathology 2011 6:16
    Content type: Case Report Published on:

  38. The patient was an 84-year-old woman who had the onset of truncal ataxia at age 77 and a history of Basedow's disease. Her ataxic gait gradually deteriorated. She could not walk without support at age 81 and s...

    Authors: Kazunori Nanri, Makoto Shibuya, Takeshi Taguchi, Akira Hasegawa and Nobuyuki Tanaka
    Citation: Diagnostic Pathology 2011 6:14
    Content type: Case Report Published on:

  39. We encountered two cases of endometrioid carcinoma of uterus with extensive surface epithelial changes (SECs) mimicking serous borderline tumor (SBT) of the ovary. The first case was a well-differentiated endo...

    Authors: Kamaljeet Singh, Rochelle A Simon, Cunxian Zhang and M Ruhul Quddus
    Citation: Diagnostic Pathology 2011 6:13
    Content type: Case Report Published on:

  40. Claudins are integral membrane proteins that are involved in forming cellular tight junctions. One member of the claudin family, claudin-3, has been shown to be overexpressed in breast, ovarian, and pancreatic...

    Authors: Tanner L Bartholow, Uma R Chandran, Michael J Becich and Anil V Parwani
    Citation: Diagnostic Pathology 2011 6:12
    Content type: Research Published on:

  41. Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes...

    Authors: Souhir Khedhiri, Latifa Chkioua, Salima Ferchichi, Abdelhedi Miled and Sandrine Laradi
    Citation: Diagnostic Pathology 2011 6:11
    Content type: Research Published on:

  42. Osteoid osteoma of the spine is a relatively rare bone-forming tumor. Pain that is worse at night and relieved by aspirin and muscle contracture are the most characteristic symptoms of spinal osteoid osteoma. ...

    Authors: Michihisa Zenmyo, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya and Kosei Ijiri
    Citation: Diagnostic Pathology 2011 6:10
    Content type: Case Report Published on:

  43. We report a case of a 69-year-old man with dropped head syndrome associated with isolated neck extensor myopathy (INEM). Over a period of 2 years, he exhibited progressive inability to lift his chin off his ch...

    Authors: Michihisa Zenmyo, Masahiko Abematsu, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya and Kosei Ijiri
    Citation: Diagnostic Pathology 2011 6:9
    Content type: Case Report Published on:

  44. Cardiovascular beriberi is categorized into two main groups, according to its cause: alcoholic and non-alcoholic (dietary). Cardiovascular beriberi can also be divided into a fulminant form (Shoshin beriberi) ...

    Authors: Stefania Bello, Margherita Neri, Irene Riezzo, Mohammad Shafie Othman, Emanuela Turillazzi and Vittorio Fineschi
    Citation: Diagnostic Pathology 2011 6:8
    Content type: Case Report Published on:

  46. The immunohistochemical detection of estrogen (ER) and progesterone (PR) receptors in breast cancer is routinely used for prognostic and predictive testing. Whole slide digitalization supported by dedicated so...

    Authors: László Krecsák, Tamás Micsik, Gábor Kiszler, Tibor Krenács, Dániel Szabó, Viktor Jónás, Gergely Császár, László Czuni, Péter Gurzó, Levente Ficsor and Béla Molnár
    Citation: Diagnostic Pathology 2011 6:6
    Content type: Research Published on:

  47. Acantholytic squamous cell carcinoma (ASCC) is an uncommon histopathologic variant of SCC, characterized by marked acantholysis, wherein the tumor cells demonstrate defective cohesion to one another in the can...

    Authors: Zoran Jukić, Iva Ledinsky, Monika Ulamec, Mario Ledinsky, Božo Krušlin and Davor Tomas
    Citation: Diagnostic Pathology 2011 6:5
    Content type: Case Report Published on:

  48. This report describes an unusual EBV-negative lymphoepithelioma-like carcinoma of the vulva in a 73-year-old patient. The lesion was localised at the right minor labium and was resected by partial vulvectomy. ...

    Authors: Hans Bösmüller, Sophie Haitchi-Petnehazy, Christine Gruber, Franz Roithmeier, Wolfgang Stummvoll and Gerald Webersinke
    Citation: Diagnostic Pathology 2011 6:4
    Content type: Case Report Published on:
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