A case of postoperative hepatic granuloma presumptively caused by surgical staples/clipping materials
© Nihon-Yanagi et al. 2015
Received: 20 October 2014
Accepted: 5 May 2015
Published: 9 July 2015
A 66-year-old man with postsigmoidectomy status for colon cancer received laparoscopic partial hepatectomy due to a hepatic mass with employing titanium clips were for a vascular clamp. Histological examination showed liver metastasis from sigmoid colon cancer. Twenty-nine months after the partial hepatectomy, a mass developed on the stump at the hepatic resection. Laparoscopic left lateral segmentectomy was conducted under suspicion of cancer recurrence and an automatic titanium stapling device was used. The macroscopically cut surface of the liver showed a grey-white solid nodule measuring 23 x 20 mm and involving metal clips. The nodule was consistent with granuloma microscopically. Twenty-three months after the segmentectomy, a mass reappeared on the hepatic radial margin and an open left lateral hepatic lobectomy was performed because of its growth tendency. Histopathological examination revealed granuloma similar to the previous instance. Since these nodules formed a granulomatous lesion surrounding metal staples/clips and evidence of caseous necrosis was lacking, granuloma due to surgical staples/clips was suspected. Sporadic case reports of postoperative pulmonary granuloma at the staple line have been published previously, but there are no articles detailing a case involving hepatic granuloma. We present our case as the first report of postoperative staple-line hepatic granuloma.
KeywordsHepatic granuloma Metal hypersensitivity Staple Stapler Titanium
It is important for clinicians to distinguish liver tumors detected after surgical intervention of malignant disorders from recurrent or metastatic lesions originating from the primary cancer.
Titanium is now widely used as a material in automatic stapling surgery because of its minimal irritability in the human body , but there are a number of case reports detailing significant allergic reactions caused by titanium [2–11]. Herein, we report a case of postoperative hepatic granuloma suspected of being caused by surgical staples/clipping materials.
A 66-year-old man underwent a colectomy for sigmoid colon cancer who had been initiated on hemodialysis for end-stage renal failure of unknown cause since 54 years of age and had no history of allergic diseases. Pathological examination of the cancer ultimately demonstrated a stage II type according to TNM classification. He had no sequential adjuvant chemotherapy. Fifty-eight months after the colectomy, a nodule was detected at the left hepatic lobe. A partial hepatectomy was then performed. Histological examination showed liver metastasis of the sigmoid colon cancer. Surgeons used metal clips to control bleeding at the cut surface of the liver.
Nineteen months after the latest operation, a mass developed again in the resected edge of the liver (the medial segment of the liver). A contrast-enhanced CT of the abdomen detected a 45-mm low-density mass without contrast enhancement involving a linear, high-density material. An abdominal MRI scan indicated the mass had a low signal intensity on T1-weighted images and a slight high intensity on T2-weighted images. There was a strand-like component lacking signal intensity in the middle of the mass. MR diffusion-weighted imaging depicted the mass with a high signal intensity. The patient was not given a gadolinium-contrast agent because of his renal failure. Sonazoid®-enhanced ultrasonography revealed an avascular and hypoechoic mass at Segment 4 in the plain phase, and no contrast enhancement was observed at any phase. The FDG-PET/CT scan was not performed. Finally, at twenty-three months after the latest operation, open medial segmentectomy of the liver and caudate lobectomy was conducted under suspicion of cancer recurrence because of an increase of the mass in the short term. Operators did not use additional metal staples or clips in this procedure.
Granuloma possibly due to retained staples was suspected on the basis of the histopathological findings and clinical course of the patient. To confirm sensitivity to titanium or other metals, the patient was subjected to a patch test. Titanium, vanadium and aluminum were all negative. The patient did not show any obvious recurrence in the liver 16 months postoperatively.
A search of the databases PubMed and Ichushi (in Japanese) using the query words “staple/stapler AND granuloma”, “clip/clipping AND granuloma”, “allergic granuloma” or “hepatic granuloma” yielded scattered reports involving the lung and granulomas possibly caused by surgical staples [2,3], but there were no articles referencing operations conducted for the liver.
Clips and staples applied for resection of the liver in our case were made of a titanium alloy (>90 % titanium, 2.0–3.0 % vanadium, 2.5–3.5 % aluminum). Titanium has been considered to be inert within the body , but several case reports have suggested that titanium may be a sensitizer when involving a pacemaker , orthopedic implants [5,6] or dental implants .
Although the method generally used to examine metal hypersensitivity is the epicutaneous test (so-called “patch test”), the patch test has been an examination procedure and mainly interprets the dermally-sensitized reaction and may not clearly reflect immune responses provoked by metal implants in deep tissue [12–16]. Moreover, since the test may itself induce sensitization as an irritant reaction, it can lead to a false positive or false negative result [6,13]. Furthermore, reproducibility varies due to several factors (e.g., site-to-site, inter-observer, etc.) [13,15].
Alternative testing methods have been utilized and include in vitro examinations such as the lymphocyte transformation test (LTT) or its modified version, the memory lymphocyte immunostimulation assay (MELISA®) [6,13,15]. However, there is debate among clinicians whether these tests are adequate diagnostic tools. Thus, there is currently no ideal test which is a reliable testing method for metal hypersensitivity [6,13]. Our diagnosis was therefore made comprehensively using patient history, clinical findings, and the results of the aforementioned tests in accordance with procedures used by other researchers .
Although there are several case reports of suspected hypersensitivity to titanium, the possibility remains of an allergic reaction induced by a small percentage of vanadium or aluminum released by corrosion of the titanium alloy . In the present case, staples as a causative agent had already been removed by surgical intervention, and patch tests were all negative for titanium, vanadium and aluminum. We did not employ MELISA® testing because it was not readily available in Japan. Allergic response against metal has been known as one of the forms of delayed-type hypersensitivity (type IV allergy) associated with antigen-specific T cells, but we rarely encounter a granuloma that resulted from hypersensitivity to staples, especially those developed in the liver. Therefore, no reports have described the histopathological features of this condition in the liver . However, it could easily be assumed that the infiltration pattern of lymphocytes in the lesion comprised dominant T cells, and this was verified by immunohistochemistry in this case. In addition, the fact that the band of granuloma included fewer multinucleated giant cells may suggest little concern with foreign body reaction for development of granuloma in this case.
We report the first case of hepatic granuloma resulting from possible hypersensitivity to titanium alloy staples and/or clips. The three-layered structure consisting of necrosis containing titanium alloy, a desmoplastic (fibrous) area, and a band of granuloma could be interpreted as a histological characteristic for hepatic granuloma due to titanium alloy hypersensitivity.
Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
This work was supported by Health Science Research Grants for Research on Emerging and Re-emerging Infectious Diseases (H25-shinkou-Ippan-006 and H26-shinkou-Jitsuyouka-Ippan-010) from the Ministry of Health, Labor and Welfare of Japan, the Strategic Basis on Research Grounds for Non-governmental Schools at Heisei 20th, the Strategic Research Foundation Grant-aided Project for Private Schools at Heisei 23rd, KAKENHI (#26860250, 26460460, and 26860774) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, Toho University project grants (#25-33, #26-27 and 36), a Yokohama Foundation for the Advancement of Medical Science grant to Yoichiro Okubo, Dr. Yanase’s grant to Yoichiro Okubo, and a Kurozumi Medical Foundation grant to NT.
- Steinemann SG. Titanium-the material of choice? Periodontol 2000. 1998;17:7–21.PubMedView ArticleGoogle Scholar
- Tomita M, Matsuzaki Y, Edagawa M, Shimizu T, Masaaki H, Onitsuka T. Pulmonary granuloma possibly caused by staples after video-associated thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2003;9:123–15.PubMedGoogle Scholar
- Yüksel M, Akgül AG, Evman S, Batirel HF. Suture and stapler granulomas: a word of caution. Eur J Card-Thor Surg. 2007;31:563–5.View ArticleGoogle Scholar
- Yamauchi R, Morita A, Tsuji T. Pacemaker dermatitis from titanium. Contact Dermatitis. 2000;42:52–3.PubMedGoogle Scholar
- Thomas P, Bandl W-D, Maier S, Summer B, Przybilla B. Hypersensitivity to titanium osteosynthesis with impaired fracture healing, eczema, and T-cell hyperresponsiveness in vitro: case report and review of the literature. Contact Dermatitis. 2006;55:199–202.PubMedView ArticleGoogle Scholar
- Hallab N, Merritt K, Jacobs J. Metal sensitivity in patients with orthopaedic implants. J Bone Joint Surg Am. 2001;83:428–30.PubMedView ArticleGoogle Scholar
- Sicilia A, Cuesta S, Coma G, Arregui I, Guisasola C, Ruiz E, et al. Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clin Oral Impl Res. 2008;19:823–35.View ArticleGoogle Scholar
- Bircher AJ, Stern WB. Allergic contact dermatitis from “titanium” spectacle frames. Contact Dermatitis. 2001;45:244–5.PubMedView ArticleGoogle Scholar
- High WA, Ayers RA, Adams JR, Chang A, Fitzpatrick JE. Granulomatous reaction to titanium alloy: An unusual reaction to ear piercing. J Am Acad Dermatol. 2006;55:716–20.PubMedView ArticleGoogle Scholar
- Tamai K, Mitsumori M, Fujishiro S, Kokubo M, Ooya N, Nagata Y, et al. A case of allergic reaction to surgical metal clips inserted for postoperative boost irradiation in a patient undergoing breast conserving therapy. Breast Cancer. 2001;8:90–2.PubMedView ArticleGoogle Scholar
- Hadedeya DS, Latif KA. A foreign body granuloma mimicking a tumor recurrence complicating a stapler site after a sigmoid cancer resection. World J Colorectal Surg. 2013;3. Iss. 1, Art 17.Google Scholar
- Merritt K, Brown SA. Distribution of cobalt chromium wear and corrosion products and biologic reaction. Clin Orthop Relat Res. 1996;329S:S233–43.View ArticleGoogle Scholar
- Valentine-Thon E, Müller K, Guzzi G, Kreisel S, Ohnsorge P, Sandkamp M. LTT-MELISA® is clinically relevant for detecting and monitoring metal sensitivity. Neuro Endocrinol Lett. 2006;27:17–24.PubMedGoogle Scholar
- Müller K, Valentine-Thon E. Hypersensitivity to titanium: clinical and laboratory evidence. Neuro Endocrinol Lett. 2006;27 Suppl 1:31–5.PubMedGoogle Scholar
- Spiewak R. Patch testing for contact allergy and allergic contact dermatitis. Open Allergy J. 2008;1:42–51.View ArticleGoogle Scholar
- Stejskal V, Hudecek R, Stejskal J, Sterzl I. Diagnosis and treatment of metal-induced side-effects. Neuro Endocrinol let. 2006;27 Suppl 1:7–16.Google Scholar
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