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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. Abnormally sustained immune reactions drive B-cell proliferation in some cases of marginal zone lymphoma but the CD4+ T-cell subsets, which are likely to contribute to the B-cell responses in the tumour microenvi...

    Authors: Katherine Wickenden, Nadia Nawaz, Sami Mamand, Deevia Kotecha, Amy L. Wilson, Simon D. Wagner and Matthew J. Ahearne
    Citation: Diagnostic Pathology 2018 13:74
    Content type: Research Published on:

  2. Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in Asia; however, the molecular mechanism in its tumorigenesis remains unclear. Abnormal expression of claudins (CLDNs), a family of t...

    Authors: Lemeng Sun, Liangshu Feng and Jiuwei Cui
    Citation: Diagnostic Pathology 2018 13:72
    Content type: Research Published on:

  3. This article [1] is retracted at request of the Editor. After publication of this article [1] concerns were raised regarding aspects of the methodology, including the choice of stains being inappropriate or in...

    Authors: Jian Tan, Jianpeng Hu, Yonghui He and Feilun Cui
    Citation: Diagnostic Pathology 2018 13:71
    Content type: Retraction Note Published on:

    The original article was published in Diagnostic Pathology 2015 10:198

  6. Non-small cell lung cancer (NSCLC) and melanoma are frequent entities in routine diagnostics. Whereas the differential diagnosis is usually straight forward based on histomorphology, it can be challenging in p...

    Authors: Mark Kriegsmann, Katharina Kriegsmann, Alexander Harms, Rémi Longuespée, Christiane Zgorzelski, Jonas Leichsenring, Thomas Muley, Hauke Winter, Daniel Kazdal, Benjamin Goeppert and Arne Warth
    Citation: Diagnostic Pathology 2018 13:68
    Content type: Research Published on:

  7. Conventional parameters including Ki67, hormone receptor and Her2/neu status are used for risk stratification for breast cancer. The serine protease urokinase plasminogen activator (uPA) and the plasminogen ac...

    Authors: Hans-Ullrich Völker, Michael Weigel, Annette Strehl and Lea Frey
    Citation: Diagnostic Pathology 2018 13:67
    Content type: Research Published on:

  8. Triple-negative breast cancers (TNBCs) are a group of heterogeneous diseases with various morphology, prognosis, and treatment response. Therefore, it is important to identify valuable biomarkers to predict th...

    Authors: Miao Ruan, Tian Tian, Jia Rao, Xiaoli Xu, Baohua Yu, Wentao Yang and Ruohong Shui
    Citation: Diagnostic Pathology 2018 13:66
    Content type: Research Published on:

  9. Pilomatricoma is a relatively common benign cutaneous adnexal neoplasm with differentiation towards the hair matrix, inner sheath of hair follicle and hair cortex. Proliferating pilomatricoma is a rare variant...

    Authors: Nozomu Kurose, Manabu Yamashita, Mariko Nakano, Xin Guo, Akihiro Shioya, Satoko Nakada, Hiroshi Minato and Sohsuke Yamada
    Citation: Diagnostic Pathology 2018 13:65
    Content type: Case Report Published on:

  10. Tumor budding, meaning a detachment of tumor cells at the invasion front of colorectal carcinoma (CRC) into single cells or clusters (<=5 tumor cells), has been shown to correlate to an inferior clinical outco...

    Authors: Cleo-Aron Weis, Jakob Nikolas Kather, Susanne Melchers, Hanaa Al-ahmdi, Marion J. Pollheimer, Cord Langner and Timo Gaiser
    Citation: Diagnostic Pathology 2018 13:64
    Content type: Research Published on:

  11. Breast cancer is by far the most frequent cancer among women. The proliferative index, Ki-67, is more and more taken into consideration for treatment decisions. However, the reliability of the established Ki-6...

    Authors: Essam Ayad, Ahmed Soliman, Shady Elia Anis, Amira Ben Salem, Pengchao Hu and Youhong Dong
    Citation: Diagnostic Pathology 2018 13:63
    Content type: Research Published on:

  12. Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphologic...

    Authors: Lourdes Peña-Jaimes, Irene González-García, María Eugenia Reguero-Callejas, Ignacio Pinilla-Pagnon, Belén Pérez-Mies, Víctor Albarrán-Artahona, Noelia Martínez-Jañez, Juan Manuel Rosa-Rosa and José Palacios
    Citation: Diagnostic Pathology 2018 13:62
    Content type: Case Report Published on:

  13. Although the primary malignant spleen tumor is relatively rare, lymphoma is the most common splenic malignancy. It can have quite different clinical manifestations that usually lead to relatively poor outcomes...

    Authors: Jing Chang, Qing Chen, Yuan Jian, Ping Wei, Guang-Zhong Yang, Ying Wang, Xiang-Yang Fang and Qian-Mei Sun
    Citation: Diagnostic Pathology 2018 13:61
    Content type: Case Report Published on:

  14. Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade...

    Authors: Hayriye Tatli Dogan, Merve Kiran, Burak Bilgin, Aydan Kiliçarslan, Mehmet Ali Nahit Sendur, Bülent Yalçin, Arslan Ardiçoglu, Ali Fuat Atmaca and Berrak Gumuskaya
    Citation: Diagnostic Pathology 2018 13:60
    Content type: Research Published on:

  15. In vitro studies showed that the aryl hydrocarbon receptor (AHR) contributed to the development of cutaneous squamous cell carcinomas, but supporting clinical data are lacking.

    Authors: Zhan-Yan Pan, Jia Chen, Qiong Wu, Ting-Ting Hu, Lingyi Lu and Qiang Ju
    Citation: Diagnostic Pathology 2018 13:59
    Content type: Research Published on:

  16. After publication of this work [1], the authors noticed that the first names and last names of all the authors were inverted. In the original manuscript, they appear on PubMed as:

    Authors: Emmanuel Rivkine, Léa Marciano, Claude Polliand, Antonio Valenti, Marianne Ziol, Christophe Poncelet and Christophe Barrat
    Citation: Diagnostic Pathology 2018 13:58
    Content type: Correction Published on:

    The original article was published in Diagnostic Pathology 2012 7:62

  17. The expression of high temperature requirement factor A1 (Htra1) has been reported to be decreased in ovarian carcinoma, but its prognostic effect remains undetermined.

    Authors: Andréanne Gagné, Bernard Têtu, Michèle Orain, Stéphane Turcotte, Marie Plante, Jean Grégoire, Marie-Claude Renaud, Isabelle Bairati and Dominique Trudel
    Citation: Diagnostic Pathology 2018 13:57
    Content type: Research Published on:

    The Correction to this article has been published in Diagnostic Pathology 2018 13:75

  18. Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas. Previous studies have shown that MET protein overexpressed in MFS patients and can serve as a prognostic factor. The reasons for MET prote...

    Authors: Shirong Ma, Linni Fan, Yixiong Liu, Yingmei Wang, Kangjie Yu, Lifeng Wang, Na Fang, Fang Liu, Shuangping Guo and Zhe Wang
    Citation: Diagnostic Pathology 2018 13:56
    Content type: Research Published on:

  19. HPV 18 is one of the most prevalent oncogenic types, only second to HPV 16, and included in the licensed vaccines on the market. In this study, we describe the production and characterization of a panel of mon...

    Authors: Yao Zhang, Ye He, Ling Li, Shutian Liang, Mei Yan, Dongyan Ren, Zengmin Yang, Wenli Zhao, Luyan Miao, Haijiang Zhang and Yongjiang Liu
    Citation: Diagnostic Pathology 2018 13:55
    Content type: Research Published on:

  20. Metanephric adenoma is a rare, benign renal neoplasm with occasional misdiagnosis. However, its molecular characterization is not fully understood.

    Authors: Ying Ding, Cong Wang, Xuejie Li, Yangyang Jiang, Ping Mei, Wenbin Huang, Guoxin Song, Jinsong Wang, Guoqiang Ping, Ran Hu, Chen Miao, Xiao He, Gang Chen, Hai Li, Yan Zhu and Zhihong Zhang
    Citation: Diagnostic Pathology 2018 13:54
    Content type: Research Published on:

  21. Primary angiosarcoma of the kidney is a rare and aggressive malignant tumor presenting with a recognizable vascular differentiation. Its prognosis is fatal and the pathogenesis remains unclear. Renal angiomyol...

    Authors: Hongwei Guan, Lizhi Zhang, Qiuping Zhang, Wenjing Qi, Suling Xie, Jinping Hou and Huali Wang
    Citation: Diagnostic Pathology 2018 13:53
    Content type: Case Report Published on:

  22. Intramuscular / cellular myxomas and low-grade myxofibrosarcomas are two different tumor entities with a significant histological overlap, especially if dealing with small biopsies. Despite the morphological s...

    Authors: Sandra Sunitsch, Magdalena Maria Gilg, Karl Kashofer, Franz Gollowitsch, Andreas Leithner and Bernadette Liegl-Atzwanger
    Citation: Diagnostic Pathology 2018 13:52
    Content type: Research Published on:

  23. Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. This study aimed to describe a case of distinctive melanotic Xp11 TR...

    Authors: Hongbiao Jing, Hong Wei, Hongtu Yuan, Yahong Li, Ning Li and Dianbin Mu
    Citation: Diagnostic Pathology 2018 13:51
    Content type: Case Report Published on:

  24. Cutaneous epithelioid angiomatous nodule (CEAN) is a very rare and relatively recently recognized vascular proliferation characterized usually by minimal cytological atypia and accompanying mitotic activity. A...

    Authors: Runjan Chetty, Zaid S. Kamil, Ami Wang, Ayman Al Habeeb and Danny Ghazarian
    Citation: Diagnostic Pathology 2018 13:50
    Content type: Research Published on:

  25. Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddP...

    Authors: Chenguang Li, Rui Jia, Hailin Liu, Bin Zhang and Changli Wang
    Citation: Diagnostic Pathology 2018 13:49
    Content type: Research Published on:

  26. Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are benign and malignant, basaloid salivary gland neoplasms, respectively. These tumors show a dual-cell proliferation of inner luminal/ductal cell...

    Authors: Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Junpei Wada, Shogo Urabe, Takashi Hirano, Kenji Kawano, Masashi Suzuki, Shigeo Yokoyama and Tsutomu Daa
    Citation: Diagnostic Pathology 2018 13:48
    Content type: Research Published on:

  27. Several anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) therapies have shown encouraging safety and clinical activity in a variety of tumor types. A potential role for PD-L1...

    Authors: Paul Scorer, Marietta Scott, Nicola Lawson, Marianne J. Ratcliffe, Craig Barker, Marlon C. Rebelatto and Jill Walker
    Citation: Diagnostic Pathology 2018 13:47
    Content type: Research Published on:

  28. CD5-positive diffuse large B-cell lymphoma (DLBCL) and intravascular large B-cell lymphoma (IVL) are recognized as rare subsets of large B-cell lymphoma with poor prognosis. These two categories have similar c...

    Authors: Rieko Kano, Hiroaki Masaie, Akihisa Hino, Hironao Yasuoka, Shigenori Nagata, Jun Ishikawa and Shin-ichi Nakatsuka
    Citation: Diagnostic Pathology 2018 13:46
    Content type: Case Report Published on:

  29. Metastasis-associated in colon cancer 1 (MACC1) has been reported to promote tumor cell invasion and metastasis. Cancer stem cells and epithelial-mesenchymal transition (EMT) have also been reported to promote...

    Authors: Bo Zhu, Yichao Wang, Xiaolin Wang, Shiwu Wu, Lei Zhou, Xiaomeng Gong, Wenqing Song and Danna Wang
    Citation: Diagnostic Pathology 2018 13:45
    Content type: Research Published on:

  30. Salivary gland malignancies are a very heterogeneous group of cancers, with histologically > 20 different subtypes, and prognosis varies greatly. Their etiology is unknown, however, a few small studies show pr...

    Authors: Linnea Haeggblom, Ramona Gabriela Ursu, Leila Mirzaie, Tove Attoff, Caroline Gahm, Lalle Hammarstedt Nordenvall and Anders Näsman
    Citation: Diagnostic Pathology 2018 13:44
    Content type: Research Published on:

  31. Ovarian serous borderline tumor/atypical proliferative serous tumor (SBT/APST) is characterized by presenting at an early stage and much longer survival than high-grade serous carcinoma. Given that the prognos...

    Authors: Chiaki Kubo, Shigenori Nagata, Takeshi Fukuda, Rieko Kano, Takaaki Tanaka, Katsuyuki Nakanishi, Masahiko Ohsawa and Shin-ichi Nakatsuka
    Citation: Diagnostic Pathology 2018 13:43
    Content type: Case Report Published on:

  32. The incidence of abnormal cervical smears in the United Arab Emirates (UAE) is 3.6%. Data regarding specific high-risk HPV (hrHPV) genotypes are insufficient. Identification of hrHPV subtypes is essential to a...

    Authors: Alia Albawardi, M. Ruhul Quddus, Shamsa Al Awar and Saeeda Almarzooqi
    Citation: Diagnostic Pathology 2018 13:42
    Content type: Research Published on:

  34. The editor has retracted this article [1] because of flaws and inconsistencies in the methodology, reporting and interpretation of the data.

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao and Tao Li
    Citation: Diagnostic Pathology 2018 13:40
    Content type: Retraction Note Published on:

    The original article was published in Diagnostic Pathology 2018 13:11

  35. Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Based on the limited number of case reports that exist, the association of Epstein–Barr virus (EBV) with primary thyroid LELCs see...

    Authors: Chih-Yi Liu and Shih-Hung Huang
    Citation: Diagnostic Pathology 2018 13:39
    Content type: Case Report Published on:

  36. The Ki-67 Labelling Index (LI) is used as an ancillary tool in glioma diagnostics. Interobserver variability has been reported and no precise guidelines are available. Nor is it known whether novel digital app...

    Authors: Ljudmilla A. G. Nielsen, Julie A. Bangsø, Kim H. Lindahl, Rikke H. Dahlrot, Jacob v. B. Hjelmborg, Steinbjørn Hansen and Bjarne W. Kristensen
    Citation: Diagnostic Pathology 2018 13:38
    Content type: Research Published on:

  37. Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have b...

    Authors: Rodrigo Javier, Nawal Shaikh, Maciej S. Lesniak, Adam Sonabend, Roger Stupp, Amir Behdad and Craig Horbinski
    Citation: Diagnostic Pathology 2018 13:37
    Content type: Case Report Published on:

  38. Nuclear forkhead box protein P1 (N-FOXP1) expression in invasive breast cancer has been documented in the literature. However, the FOXP1 expression patterns at different stages of breast cancer progression are...

    Authors: Bao-Hua Yu, Bai-Zhou Li, Xiao-Yan Zhou, Da-Ren Shi and Wen-Tao Yang
    Citation: Diagnostic Pathology 2018 13:36
    Content type: Research Published on:

  39. The mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease resulting from the defective activity of the enzyme α-L-iduronidase (IDUA). The disease has three major clinical subtypes (severe Hurler syn...

    Authors: Latifa Chkioua, Hela Boudabous, Ibtissem Jaballi, Oussama Grissa, Hadhami Ben Turkia, Neji Tebib and Sandrine Laradi
    Citation: Diagnostic Pathology 2018 13:35
    Content type: Research Published on:

  40. We report the first case of composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL) and high-grade B-cell lymphoma with MYC and BCL2 rearrangem...

    Authors: Alison M. Moore, Olga Moshkin, Gordon J. Swain, Susan Crocker and David P. LeBrun
    Citation: Diagnostic Pathology 2018 13:34
    Content type: Case Report Published on:

  41. Radiotherapy is one of the most common and effective treatment methods for cancer, and improving the radiosensitivity of tumor tissues during the treatment process is vital. We report the mechanisms of glycoge...

    Authors: Jialin Ren, Tingting Liu, Yang Han, Qiongzi Wang, Yanzhi Chen, Guang Li and Lihong Jiang
    Citation: Diagnostic Pathology 2018 13:33
    Content type: Research Published on:

  42. The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after deliver...

    Authors: Kenichi Mizutani, Sohsuke Yamada, Xin Guo, Chizuru Futatsuya, Motona Kumagai, Akihiro Shioya, Akane Aikawa, Satoko Nakada, Nozomu Kurose, Hiroshi Minato and Takayuki Nojima
    Citation: Diagnostic Pathology 2018 13:32
    Content type: Case Report Published on:

  43. Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections.

    Authors: Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao and Zhe Wang
    Citation: Diagnostic Pathology 2018 13:31
    Content type: Research Published on:

  44. Recent research supports a significant role of immune checkpoint inhibitors in the treatment of solid tumors. However, relevant reports for programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphoc...

    Authors: Haiyue Wang, Zhongwu Li, Bin Dong, Wei Sun, Xin Yang, Ruping Liu, Lixin Zhou, Xiaozheng Huang, Ling Jia and Dongmei Lin
    Citation: Diagnostic Pathology 2018 13:30
    Content type: Research Published on:

  45. Telepathology (TP) provides remote pathology services for primary diagnosis practices, including intraoperative consultation of surgical pathology; it has not been widely implemented in China. In this study, t...

    Authors: Yingxin Huang, Yan Lei, Qi Wang, Dazhou Li, Lili Ma, Lili Guo, Minshan Tang, Guanglong Liu, Qianwen Yan, Lan Shen, Guihui Tong, Zhiliang Jing, Yan Zhang and Yongjian Deng
    Citation: Diagnostic Pathology 2018 13:29
    Content type: Research Published on:

  46. Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK pro...

    Authors: Ryuko Nakayama, Yuki Togashi, Satoko Baba, Yo Kaku, Yuki Teramoto, Takaki Sakurai, Hironori Haga and Kengo Takeuchi
    Citation: Diagnostic Pathology 2018 13:28
    Content type: Case Report Published on:

  47. The diagnosis of granulomatous amoebic encephalitis is challenging for clinicians because it is a rare and lethal disease. Previous reports have indicated that Acanthamoeba with some specific genotypes tend to ca...

    Authors: Takahiro Matsui, Tetsuo Maeda, Shinsuke Kusakabe, Hideyuki Arita, Kenji Yagita, Eiichi Morii and Yuzuru Kanakura
    Citation: Diagnostic Pathology 2018 13:27
    Content type: Case Report Published on:

  48. The editor has retracted this article [1] because it shows significant overlap with the following articles (amongst others) [2, 3]. None of the authors responded to correspondence regarding this retraction.

    Authors: Huifen Li, Weihua Huang and Rongcheng Luo
    Citation: Diagnostic Pathology 2018 13:26
    Content type: Retraction Note Published on:

    The original article was published in Diagnostic Pathology 2015 10:117

  49. The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85–90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phen...

    Authors: Perikles Kosmidis, Barbara Mankel, Falko Fend and Patrick Adam
    Citation: Diagnostic Pathology 2018 13:25
    Content type: Research Published on:

  50. Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-...

    Authors: Yuichiro Hatano, Shinya Fukuda, Hiroshi Makino, Hiroyuki Tomita, Ken-ichirou Morishige and Akira Hara
    Citation: Diagnostic Pathology 2018 13:24
    Content type: Case Report Published on:
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Diagnostic Pathology

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