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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  2. Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with poor prognosis in urothelial bladder cancer in several independent studies. The pre...

    Authors: Christoffer Wennersten, Gustav Andersson, Karolina Boman, Björn Nodin, Alexander Gaber and Karin Jirström
    Citation: Diagnostic Pathology 2014 9:189
    Content type: Research Published on:

  3. Primary pulmonary lymphoma (PPL) is rare and easily misdiagnosed because of the lack of typical clinical features. It most commonly involves elderly patients aged between 60 and 70 years, and pathological diag...

    Authors: Jin Zhu, Yingmei Wang, Li Gong and Gaosheng Huang
    Citation: Diagnostic Pathology 2014 9:188
    Content type: Case Report Published on:

  4. Trochanteric fractures (TF) have become a major source of morbidity and mortality in elderly. We conducted this study to compare the outcomes of unstable trochanteric fractures treated with the InterTan nail a...

    Authors: Dankai Wu, Guangkai Ren, Chuangang Peng, Xuanlin Zheng, Fengmin Mao and Yueyang Zhang
    Citation: Diagnostic Pathology 2014 9:191
    Content type: Research Published on:

  5. Numerous clinical studies have shown that anti-EGFR therapies are effective only in a subset of patients with colorectal cancer. Mutations in the KRAS and BRAF genes have been confirmed as negative predictors ...

    Authors: Daniela Martinetti, Rosario Costanzo, Shahin Kadare, Mehdiu Alimehmeti, Cristina Colarossi, Vincenzo Canzonieri, Massimiliano Berretta and Lorenzo Memeo
    Citation: Diagnostic Pathology 2014 9:187
    Content type: Research Published on:

  6. Individuals born with a low birth weight (LBW) have a higher risk of developing kidney dysfunction during their lifetime and sometimes exhibit focal segmental glomerulosclerosis (FSGS) lesions in their glomeru...

    Authors: Toshiyuki Imasawa, Masashi Tanaka, Naoki Maruyama, Takehiko Kawaguchi, Yutaka Yamaguchi, Rodrigue Rossignol, Hiroshi Kitamura and Motonobu Nishimura
    Citation: Diagnostic Pathology 2014 9:181
    Content type: Research Published on:

  8. Recent studies have linked chemotherapy resistance to the altered expression of microRNAs (miRNAs). Thus, miRNA-based approaches to modulating sensitivity to temozolomide (TMZ) may overcome chemoresistance. Th...

    Authors: Hao Wu, Qiang Liu, Tao Cai, Yu-dan Chen, Fan Liao and Zhi-fei Wang
    Citation: Diagnostic Pathology 2014 9:173
    Content type: Research Published on:

  9. Alkaptonuria (AKU) is an inborn error of catabolism due to a deficient activity of homogentisate 1,2-dioxygenase. Patients suffer from a severe arthropathy, cardiovascular and kidney disease but other organs a...

    Authors: Lia Millucci, Lorenzo Ghezzi, Giulia Bernardini, Daniela Braconi, Pietro Lupetti, Federico Perfetto, Maurizio Orlandini and Annalisa Santucci
    Citation: Diagnostic Pathology 2014 9:185
    Content type: Research Published on:

  10. Many epidemiological studies have suggested an association between estrogen receptor-beta (ER-β) polymorphisms with endometriosis risk. However, the results of these studies have been inconsistent. In the pres...

    Authors: Renyong Guo, Nengneng Zheng, Shiping Ding, Ying Zheng and Limin Feng
    Citation: Diagnostic Pathology 2014 9:184
    Content type: Research Published on:

  11. Recent studies have demonstrated that microRNA-22 (miR-22) was deregulated in many types of cancers and was involved in various cellular processes related to carcinogenesis. However, the clinical significance ...

    Authors: Wei-na Wan, Yu-qin Zhang, Xue-mei Wang, Yan-jun Liu, Yi-xia Zhang, Yan-hong Que, Wen-jing Zhao and Ping Li
    Citation: Diagnostic Pathology 2014 9:178
    Content type: Research Published on:

  12. Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible asso...

    Authors: Yiguo Yan, Jianzhong Hu, Hongbin Lu and Wenjun Wang
    Citation: Diagnostic Pathology 2014 9:177
    Content type: Research Published on:

  13. To identify critical genes and biological pathways in acute lung injury (ALI), a comparative analysis of gene expression profiles of patients with ALI + sepsis compared with patients with sepsis alone were per...

    Authors: Zhiqiang Guo, Chuncheng Zhao and Zheng Wang
    Citation: Diagnostic Pathology 2014 9:176
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2015 10:51

  14. The relationship between homocysteine (Hcy) and diabetic retinopathy (DR) remains unclear to date. Therefore, a systematic review and meta-analysis was performed on the relationship between Hcy level and DR.

    Authors: Chong Xu, Yan Wu, Guodong Liu, Xiaoqiang Liu, Fang Wang and Jing Yu
    Citation: Diagnostic Pathology 2014 9:167
    Content type: Original article Published on:

  15. Prostate cancer (PCa) is a biologically heterogeneous disease with considerable variation in clinical aggressiveness. In this study, bioinformatics was used to detect the patterns of gene expression alteration...

    Authors: Jiling Wen, Rongbing Li, Xiaofei Wen, Guangming Chou, Jiasun Lu, Xuelei Wang and Yongchao Jin
    Citation: Diagnostic Pathology 2014 9:156
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2015 10:11

  16. Intraductal tubular adenoma of the pancreas, pyloric gland type (ITA), is an infrequent intraductal benign lesion located in the main duct and large branch duct of the pancreas. The purpose of this report is t...

    Authors: Xiaoyan Chang, Ying Jiang, Ji Li and Jie Chen
    Citation: Diagnostic Pathology 2014 9:172
    Content type: Research Published on:

  17. Nucleolin, as a multifunctional protein, has been demonstrated to play an oncogenic role in human hepatocellular carcinoma (HCC). The aim of this study was to investigate the expression pattern of nucleolin in...

    Authors: XiaoDong Guo, Lu Xiong, Lingxiang Yu, Ruisheng Li, ZhaoHai Wang, Bo Ren, JingHui Dong, Boan Li and Dadong Wang
    Citation: Diagnostic Pathology 2014 9:175
    Content type: Research Published on:

  18. Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have dr...

    Authors: Irina Amorim, Marian A Taulescu, Andreia Ferreira, Alexandra Rêma, Celso A Reis, Augusto M Faustino, Cornel Cătoi and Fátima Gärtner
    Citation: Diagnostic Pathology 2014 9:166
    Content type: Short report Published on:

  19. Epidermal Growth Factor Receptor (EGFR) targeting therapies are currently of great relevance for the treatment of lung cancer. For this reason, in addition to mutational analysis immunohistochemistry (IHC) of ...

    Authors: Rania Gaber, Iris Watermann, Christian Kugler, Nils Reinmuth, Rudolf M Huber, Philipp A Schnabel, Ekkehard Vollmer, Martin Reck and Torsten Goldmann
    Citation: Diagnostic Pathology 2014 9:165
    Content type: Research Published on:

  20. Association between Cyclin D1 (CCND1) polymorphism and cervical cancer risk are conflicting with published articles. We performed a meta-analysis to investigate the association between CCND1 G870A polymorphism...

    Authors: Yuan-Yuan Hu, Rong Zheng, Chong Guo and Yu-Ming Niu
    Citation: Diagnostic Pathology 2014 9:168
    Content type: Methodology Published on:

  21. miRNAs are involved in coordinating a variety of cellular processes by regulating their target genes. Aberrant expression of miRNAs is correlated with various cancers. Previous studies have shown that miR-337 ...

    Authors: Rui Zhang, Hong Leng, Junwen Huang, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Xiaonan Chen and Guoqiang Zhao
    Citation: Diagnostic Pathology 2014 9:171
    Content type: Research Published on:

  22. Primay spleen NK/T cell lymphoma is very rare. We report a case of 39-years-old male of primary splenic NK/T cell lymphoma with bone marrow involvement and CD30 positive expression.

    Authors: Qinghua Cao, Yan Huang, Ziyin Ye, Ni Liu, Shuhua Li and Tingsheng Peng
    Citation: Diagnostic Pathology 2014 9:169
    Content type: Case Report Published on:

  23. Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue tumor typically affecting young to middle-aged adults. Despite its otherwise benign histologic appearance and indolent nature, it can have fully mali...

    Authors: Aiko Kurisaki-Arakawa, Yoshiyuki Suehara, Atsushi Arakawa, Tatsuya Takagi, Michiko Takahashi, Keiko Mitani, Kazuo Kaneko, Takashi Yao and Tsuyoshi Saito
    Citation: Diagnostic Pathology 2014 9:163
    Content type: Case Report Published on:

  24. The biological processes and molecular mechanisms underlying miR-107 remain unclear in gastric cancer(GC). In this study, we aimed to investigate the expression, biological functions and mechanisms of miR-107 ...

    Authors: Yan-qiang Song, Xu-hui Ma, Gui-liang Ma, Bin Lin, Chao Liu, Quan-jiang Deng and Wen-ping Lv
    Citation: Diagnostic Pathology 2014 9:164
    Content type: Research Published on:

  25. Lymphomas are common malignancies that have various subtypes with many overlapping histologic, immunophenotypic and genetic features. Therefore, discordance in classifying lymphoma among pathologists may be en...

    Authors: Tawatchai Pongpruttipan, Sanya Sukpanichnant, Thamathorn Assanasen, Lertlakana Bhoopat, Kanita Kayasut, Wasana Kanoksil and Pongsak Wannakrairot
    Citation: Diagnostic Pathology 2014 9:162
    Content type: Research Published on:

  26. The usefulness of serological tests for detection of P. aeruginosa pulmonary infection in cystic fibrosis (CF) is controversial. Here, we assessed the value of detecting anti-P. aeruginosa IgG by a quantitative e...

    Authors: Renan Marrichi Mauch, Cláudio Lúcio Rossi, José Dirceu Ribeiro, Antínio Fernando Ribeiro, Marcos Tadeu Nolasco da Silva and Carlos Emílio Levy
    Citation: Diagnostic Pathology 2014 9:158
    Content type: Research Published on:

  28. Whether microRNA-130b(miR-130b) can serve as a prognostic biomarker of hepatocellular carcinoma (HCC) has not been investigated. In the present study, we investigated the feasibility of miR-130b as a novel pro...

    Authors: Wen-yao Wang, Hong-fei Zhang, Lei Wang, Yan-peng Ma, Fei Gao, Shao-jun Zhang and Li-chao Wang
    Citation: Diagnostic Pathology 2014 9:160
    Content type: Research Published on:

  29. The different expression level of Dickkopf-1 (DKK-1) in different cancers shows that the function of DKK-1 depends on the histological type of the cancer cells and the tissue microenvironment. To our knowledge...

    Authors: Shao-jie Zhou, Shou-rong Zhuo, Xiao-qing Yang, Chun-xin Qin and Zi-liang Wang
    Citation: Diagnostic Pathology 2014 9:161
    Content type: Research Published on:

  30. The prognosis of patients with metastatic melanomas is extremely heterogeneous. Therefore, identifying high-risk subgroups by using innovative prediction models would help to improve selection of appropriate m...

    Authors: Rongyi Chen, Guoxue Zhang, Ying Zhou, Nan Li and Jiaxi Lin
    Citation: Diagnostic Pathology 2014 9:155
    Content type: Research Published on:

  31. Numerous studies examining the relationship between CD44 expression and prognostic impact in patients with osteosarcoma have yielded inconclusive results. The aim of this meta-analysis was carried out to inves...

    Authors: Yu Liu, Yongwei Wu, Sanjun Gu, Zhenzhong Sun, Yongjun Rui, Jianbing Wang, Yao Lu, Haifeng Li, Kelin Xu and Peng Sheng
    Citation: Diagnostic Pathology 2014 9:140
    Content type: Research Published on:

  32. The PIK3CA gene mutation was found to associate with prognosis and might affect molecular targeted therapy in esophageal carcinoma (EC). The aim of this study is to compare different methods for analyzing the PIK...

    Authors: Zizhen Ming, Dongxian Jiang, Qin Hu, Xiaojing Li, Jie Huang, Yifan Xu, Yalan Liu, Chen Xu, Xiuguo Hua and Yingyong Hou
    Citation: Diagnostic Pathology 2014 9:153
    Content type: Research Published on:

  33. Spironolactone is often used to treat hypertension caused by hyperaldosteronism, and as a result, can form concentrically laminated electron dense spironolactone body inclusions within the adrenal gland. Spiro...

    Authors: Kishan A Patel, Edward P Calomeni, Tibor Nadasdy and Debra L Zynger
    Citation: Diagnostic Pathology 2014 9:147
    Content type: Research Published on:

  34. Anastomosing hemangioma, a benign vascular neoplasm histologically simulating angiosarcoma, is newly recognized and has been described primarily in the genitourinary tract. Here, we present a case of renal ana...

    Authors: Li-Li Tao, Yi Dai, Weihua Yin and Joan Chen
    Citation: Diagnostic Pathology 2014 9:159
    Content type: Case Report Published on:

  35. MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target genes. A single nucleotide polymorphism (SNP) in a miRNA sequence may alter miRNA expression and/or maturation, which was proposed ...

    Authors: Zaiqiu Wang, Xiaoli Sun, Yeli Wang, Xiaofang Liu, Yuanjie Xuan and Sanyuan Hu
    Citation: Diagnostic Pathology 2014 9:146
    Content type: Research Published on:

  36. Malignant adenomyoepithelioma and adenoid cystic carcinoma are both rare malignant epithelial-myoepithelial tumors of the breast. We report a very rare case with a malignant adenomyoepithelioma combining with ...

    Authors: Ying Yang, Yanmei Wang, Jinsong He, Guoqing Pan, Xiaoyu Tuo, Aimei Jiang and Li Bian
    Citation: Diagnostic Pathology 2014 9:148
    Content type: Case Report Published on:

  37. Despite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce re...

    Authors: Partheeban Balasundaram, Manoj Kumar Singh, Amit Kumar Dinda, Alok Thakar and Rajni Yadav
    Citation: Diagnostic Pathology 2014 9:145
    Content type: Research Published on:

  38. Detection of B cell clonality is useful for assisting in the diagnosis of B cell lymphomas. Clonality assessment can be accomplished through evaluation of KAPPA and LAMBDA light chain expression. Currently, only ...

    Authors: Lisa M Rimsza, William A Day, Sarah McGinn, Anne Pedata, Yasodha Natkunam, Roger Warnke, James R Cook, Teresa Marafioti and Thomas M Grogan
    Citation: Diagnostic Pathology 2014 9:144
    Content type: Methodology Published on:

  39. A case of an unusual unilocular cystic lesion of diameter 7 cm located retroperitoneally in the pelvis in close connection to the right adnexa of a 61 year-old woman is presented. Macroscopically, the lesion h...

    Authors: Dariusz Adamek, Carina Jägers, Maria Hejnold, Robert Jach and Bartlomiej Galarowicz
    Citation: Diagnostic Pathology 2014 9:150
    Content type: Letter to the Editor Published on:

  40. Perivascular epithelioid cell tumors (PEComas) encompass a group of rare mesenchymal neoplasms, which typically have a perivascular location with dual melanocytic and muscular differentiation. They are found i...

    Authors: Hassania Ameurtesse, Laïla Chbani, Amal Bennani, Imane Toughrai, Nouhad Beggui, Imane Kamaoui, Hinde Elfatemi, Taoufik Harmouch and Afaf Amarti
    Citation: Diagnostic Pathology 2014 9:149
    Content type: Case Report Published on:

  41. Many studies have demonstrated that chemoradiotherapy followed by surgery (CRTS) prolongs the 5-year survival rate of resectable esophageal carcinoma patients. However, the effect of CRTS on postoperative comp...

    Authors: Jiaying Deng, Chunyu Wang, Mingqiong Xiang, Fatao Liu, Yun Liu and Kuaile Zhao
    Citation: Diagnostic Pathology 2014 9:151
    Content type: Research Published on:

  42. Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of me...

    Authors: Fadwa J Altaf, Ghadeer A Mokhtar, Eman Emam, Rana Y Bokhary, Najlaa Bin Mahfouz, Samia Al Amoudi and Zuhoor K AL-Gaithy
    Citation: Diagnostic Pathology 2014 9:139
    Content type: Research Published on:

  43. TAZ is a downstream agent of Hippo signal pathway. β-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas as well as a critical component of Wnt pathway. TAZ and β-cate...

    Authors: Lidan Sun, Fei Chen, Wenna Shi, Lei Qi, Zhongmei Zhao and Jianping Zhang
    Citation: Diagnostic Pathology 2014 9:125
    Content type: Research Published on:

  44. Inflammatory myofibroblastic tumors (IMTs) mainly occur in children and young adults, usually in the first two decades of life. IMT-type tumors belong to neoplasms of an intermediate biologic potential with co...

    Authors: Zuzanna Dobrosz, Janusz Ryś, Piotr Paleń, Paweł Właszczuk and Marek Ciepiela
    Citation: Diagnostic Pathology 2014 9:138
    Content type: Case Report Published on:

  45. Overexpression of microRNA-182 (miR-182) is found in various human cancers, including non-small cell lung cancer (NSCLC). Our aim is to investigate the association of miR-182 expression with the sensitivity of...

    Authors: Fang-ling Ning, Feng Wang, Mian-li Li, Ze-shun Yu, Yan-zhang Hao and Shao-shui Chen
    Citation: Diagnostic Pathology 2014 9:143
    Content type: Research Published on:

  46. Morphine has been widely used as a clinical anesthetic and analgesic. However, abuse of morphine might result in psychological and physiological dependence. Previous studies have indicated that memory mechanis...

    Authors: Junyi Ye, Zhaoyang Yang, Candong Li, Meimei Cai, Daizhan Zhou, Qin Zhang, Yiming Wei, Ting Wang and Yun Liu
    Citation: Diagnostic Pathology 2014 9:142
    Content type: Research Published on:

  47. Glial scar formation is a common histopathological feature of traumatic brain injury (TBI). Astrogliosis and expression of transforming growth factor beta (TGF-β) are key components of scar formation and blood...

    Authors: Yuqi Liu, Zongwei Liu, Xiaoming Li, Bangwei Luo, Jian Xiong, Woting Gan, Man Jiang, Zhiyuan Zhang, Hermann J Schluesener and Zhiren Zhang
    Citation: Diagnostic Pathology 2014 9:141
    Content type: Research Published on:

  49. The effects of fascin on cell invasiveness involve changes in cell motility and matrix metalloproteinase-9 (MMP-9) activity. Previous studies on the prognostic value of fascin and MMP-9 in breast carcinoma rev...

    Authors: Nermeen Salah Youssef and Sarah Adel Hakim
    Citation: Diagnostic Pathology 2014 9:136
    Content type: Research Published on:

  50. Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among the leading causes of cancer death among the whole world. The most urgent needs are to find sensitive markers for ear...

    Authors: Zhu-qing Zhang, Hua Meng, Nan Wang, Li-na Liang, Li-na Liu, Shu-ming Lu and Yong Luan
    Citation: Diagnostic Pathology 2014 9:135
    Content type: Research Published on:
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Diagnostic Pathology

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