Articles

Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decade...

Authors: Maria Noel Marzano Rodrigues Petruzzi, Karen Cherubini, Fernanda Gonçalves Salum and Maria Antonia Zancanaro de Figueiredo

Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series

Histopathological diagnosis is important for prognostication and choice of treatment in patients with cancer in the lung. Metastases to the lungs are common and need to be distinguished from primary lung cance...

Authors: Kajsa Ericson-Lindquist, Anna Johansson, Per Levéen, Göran Elmberger, Göran Jönsson, Johan Staaf and Hans Brunnström

Case report: a case of eruptive collagenoma occurring in esophagus and intestine

Eruptive collagenoma is a rare disease. All of the previously reported cases were located on the skin. Here we report such a case occurring in esophagus and intestine.

Authors: Ping Gao, Lili Jing, Hai Huang, Cuiping Zhang and Junmei Hao

Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review

Imaging and histology of clear-cell ependymoma and cerebellum-based hemangioblastoma are similar; distinguishing between them is a diagnostic challenge.

Authors: Xiu-Peng Zhang, Yang Liu, Di Zhang, Qin Zheng, Chen Wang, Liang Wang, Qing-Chang Li, Xue-Shan Qiu and En-Hua Wang

Malignant gastrointestinal neuroectodermal tumor: a case report and review of the literature

Malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare entity that was first described by Zambrano et al. in 2003 as “Clear cell sarcoma-like tumor of the gastrointestinal tract”. It shar...

Authors: Mohammed J. Alyousef, Jumana A. Alratroot, Tarek ElSharkawy, Mohamed A. Shawarby, Mohammad A. Al hamad, Tarek M. Hashem and Ahmed Alsayyah

Diagnostic accuracy of oral cancer cytology in a pilot study

Recently, cytology has been applied to the diagnosis of oral lesions. We aimed to explore the diagnostic accuracy of oral cytology based on the histological diagnosis.

Authors: Joji Sekine, Eiji Nakatani, Katsumi Hideshima, Teruaki Iwahashi and Hiroshi Sasaki

Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH)

Idiopathic pulmonary arterial hypertension (IPAH) is a rare, fatal disease of unknown pathogenesis. Evidence from our recent study suggests that IPAH pathogenesis is related to upregulation of the Wnt/planar c...

Authors: Shun Yanai, Megumi Wakayama, Haruo Nakayama, Minoru Shinozaki, Hisayuki Tsukuma, Naobumi Tochigi, Tetsuo Nemoto, Tsutomu Saji and Kazutoshi Shibuya

Uterine epithelioid leiomyosarcoma with c-kit expression and YWHAE gene rearrangement: a case report of a diagnostic pitfall of uterine sarcoma

Uterine sarcoma is a rare tumor that is often difficult to classify based on morphological and immunohistochemical analysis alone. Limited access to molecular biological analysis in routine practice would hind...

Authors: Terufumi Kubo, Shintaro Sugita, Ryuichi Wada, Noriaki Kikuchi, Masahiro Iwasaki, Yumika Ito, Taro Sugawara, Hiromi Fujita, Makoto Emori, Ryoichi Tanaka, Hiroshi Hirano, Tsuyoshi Saito and Tadashi Hasegawa

Molecular genetics of microsatellite-unstable colorectal cancer for pathologists

Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent ...

Authors: Wei Chen, Benjamin J. Swanson and Wendy L. Frankel

Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma

Recurrence and metastasis are the usual manifestations of treatment failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), a...

Authors: Lan Yu, Bo Zhu, Shiwu Wu, Lei Zhou, Wenqing Song, Xiaomeng Gong and Danna Wang

Erratum to: Quality of sweat test (ST) based on the proportion of sweat sodium (Na) and sweat chloride (Cl) as diagnostic parameter of cystic fibrosis: are we on the right way?

Authors: Alethéa Guimarães Faria, Fernando Augusto Lima Marson, Carla Cristina de Souza Gomez, Maria Ângela Gonçalves de Oliveira Ribeiro, Lucas Brioschi Morais, Maria de Fátima Servidoni, Carmen Sílvia Bertuzzo, Eulália Sakano, Maura Goto, Ilma Aparecida Paschoal, Mônica Corso Pereira, Gabriel Hessel, Carlos Emílio Levy, Adyléia Aparecida Dalbo Contrera Toro, Andressa Oliveira Peixoto, Maria Cristina Ribeiro Simões…

HMGA2 immunostaining is a straightforward technique which helps to distinguish pulmonary fat-forming lesions from normal adipose tissue in small biopsies: a retrospective observational study about a series of 13 lung biopsies

A tracheobronchial lesion observed during an endoscopic examination is usually sampled by the pulmonologist and sent to the pathologist for microscopic examination. Adipocytes may be observed in the lamina pro...

Authors: Nicolas Piton, Émilie Angot, Florent Marguet and Jean-Christophe Sabourin

Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy

Studies have partly demonstrated the clinical validity of Ki-67 as a predictive marker in the neoadjuvant setting, but the question of the best cut-off points as well as the importance of this marker as a prog...

Authors: Balázs Ács, Veronika Zámbó, Laura Vízkeleti, A. Marcell Szász, Lilla Madaras, Gyöngyvér Szentmártoni, Tímea Tőkés, Béla Á. Molnár, István Artúr Molnár, Stefan Vári-Kakas, Janina Kulka and Anna-Mária Tőkés

Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies

The analysis of fresh frozen muscle specimens is standard following routine muscle biopsy, but this service is not widely available in countries with limited medical facilities, such as Thailand. Nevertheless,...

Authors: Chinnawut Suriyonplengsaeng, Charungthai Dejthevaporn, Chaiyos Khongkhatithum, Suda Sanpapant, Nattha Tubthong, Koset Pinpradap, Nippa Srinark and Jariya Waisayarat

Cytokeratin7 and cytokeratin19 expression in high grade cervical intraepithelial neoplasm and squamous cell carcinoma and their possible association in cervical carcinogenesis

High risk human papillomavirus (HR HPV) infects cells at the squamocolumnar junction (SCJ) of the cervix, causing cancer. Cytokeratin (CK)7 is an SCJ marker, and stains cervical neoplasia. CK19 is a binding pa...

Authors: Hojung Lee, Hyekyung Lee and Yong Kyun Cho

Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas

Cellular angiofibroma is a rare benign mesenchymal neoplasm with morphological and immunohistochemical similarities to spindle cell lipoma. Karyotypic information on cellular angiofibroma is restricted to one ...

Authors: Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Kristin Andersen, Marius Lund-Iversen and Sverre Heim

TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer

Genomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the p...

Authors: Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Wenjing Wang, Qing Li and Wen Di

An unusual case of Epstein-Barr virus-positive large B-cell lymphoma lacking various B-cell markers

Epstein-Barr virus (EBV) is associated with B-cell lymphoma in various conditions, such as immunodeficiency and chronic inflammation. We report an unusual case of EBV-positive diffuse large B-cell lymphoma (DL...

Authors: Shin-ichi Nakatsuka, Chikao Yutani, Masako Kurashige, Masaharu Kohara, Teruaki Nagano, Takayoshi Goto, Hiroyuki Takatsuka, Hidetaka Ifuku and Eiichi Morii

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

SESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellul...

Authors: Shaosen Chen, Weigang Yan, Weiya Lang, Jing Yu, Li Xu, Xinyu Xu, Yunlong Liu and Hongguang Bao

Anastomosing hemangioma: report of two renal cases and analysis of the literature

Anastomosing hemangioma (AH) is a very rare vascular tumor mimicking angiosarcoma, predominately observed in kidney and less frequently in other organs. We present two new renal cases of AH at opposite ends of...

Authors: Marina Perdiki, Galateia Datseri, George Liapis, Nikolaos Chondros, Ioannis Anastasiou, Maria Tzardi, Johanna K. Delladetsima and Elias Drakos

ADAR1 overexpression is associated with cervical cancer progression and angiogenesis

This study aimed to assess the role of RNA-dependent adenosine deaminase (ADAR1) in cervical squamous cell carcinoma occurrence and progression.

Authors: Ying Chen, He Wang, Wenyi Lin and Ping Shuai

A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report

Acinar cell carcinoma represents only 1–2% of exocrine pancreatic neoplasms. On exceptionally rare occasions, primary acinar cell carcinoma can occur in ectopic locations. Herein, we report a case of pure panc...

Authors: Kyoung Min Kim, Chan Young Kim, Seung-Mo Hong and Kyu Yun Jang

Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review

Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owin...

Authors: Sohsuke Yamada, Mari Kirishima, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka and Akihide Tanimoto

An unusual combined thymic carcinoma composed of squamous cell carcinoma and type AB thymoma: a rare case report

Combined thymic carcinoma is a malignant neoplasm of the thymus recently added to the 4th edition of the World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart. It invol...

Authors: Yufeng Jiang, Yang Liu, Xiuying Shi, Xiaoyun Mao, Yang Zhao and Chuifeng Fan

Clinicopathological study of 9 cases of prostate cancer involving the rectal wall

Prostate cancer involving the rectal wall is rare and may lead to diagnostic pitfalls.

Authors: Tao Tang, Zhengduo Yang, Dan Zhang, Jie Qu, Guang Liu and Shiwu Zhang

Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues

Colorectal cancer is the major cause of cancer mortality, despite development of therapeutic strategies. The novel marker tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat sho...

Authors: Min Gyoung Pak, Hyong Jong Koh and Mee Sook Roh

Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation

Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior.

Authors: Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga and Armando Gamboa-Dominguez

A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies

Despite new treatment options for hepatocellular carcinomas (HCC) recently, 5-year survival remains poor, ranging from 50 to 70%, which may attribute to the lack of early diagnostic biomarkers. Thus, developin...

Authors: Feifei Wang, Ruliang Wang, Qiuwen Li, Xueling Qu, Yixin Hao, Jingwen Yang, Huixia Zhao, Qian Wang, Guanghui Li, Fengyun Zhang, He Zhang, Xuan Zhou, Xioumei Peng, Yang Bian and Wenhua Xiao

Primary mediastinal clear cell sarcoma: a case report and review of the literature

Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and...

Authors: Long Jin, Yuxia Sui, Haili Zhu, Zhizhong Chen and Shuguang Liu

Double-hit lymphomas: clinical, morphological, immunohistochemical and cytogenetic study in a series of Brazilian patients with high-grade non-Hodgkin lymphoma

Double-hit lymphomas (DHL) are rare high-grade neoplasms characterized by two translocations: one involving the gene MYC and another involving genes BCL2 or BCL6, whose diagnosis depends on cytogenetic examinatio...

Authors: Cristiano Claudino Oliveira, Helena Maciel-Guerra, Luan Kucko, Eric Jun Hirama, Américo Delgado Brilhante, Francisco Carlos Quevedo, Isabela Werneck da Cunha, Fernando Augusto Soares, Ligia Niero-Melo, Patrícia Pintor dos Reis and Maria Aparecida Custodio Domingues

Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma

The Cks1 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor p27^kip1. It has been reported that aberrant expression of Cks1 and p27^kip1 proteins was found in v...

Authors: Lina Xu, Songqing Fan, Jin Zhao, Peng Zhou, Shuzhou Chu, Jiadi Luo, Qiuyuan Wen, Lingjiao Chen, Sailan Wen, Li Wang and Lei Shi

Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus

Haploinsufficiency of the GATA6 transcription factor gene was recently found to be the most common cause of pancreatic agenesis, a rare cause of neonatal diabetes mellitus. Although most cases are de novo, we des...

Authors: Daphne Yau, Elisa De Franco, Sarah E. Flanagan, Sian Ellard, Miriam Blumenkrantz and John J. Mitchell

Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report

Diffuse large B-cell lymphoma (DLBCL) typically leads to effacement of the nodal architecture by an infiltrate of malignant cells. Rarely (<1%), DLBCL can present with an interfollicular pattern (DLBCL-IF) pre...

Authors: Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik and Agata M. Bogusz

Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases

The origin and heterogeneity of hepatic progenitor cells (HPCs) remain unclear. This study aimed to investigate the involvement of epithelial-mesenchymal transition (EMT) in the histogenesis of HPCs.

Authors: Wei Xu, Nong-Rong Wang, Hua-Feng Wang, Qiong Feng, Jun Deng, Zhi-Qiang Gong, Jian Sun, Xiao-Liang Lou, Xue-Feng Yu, Lv Zhou, Jin-Ping Hu, Xiao-Feng Huang, Xiao-Qing Qi, Yan-Juan Deng, Rui Gong, Yan Guo…

Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has high short-term mortality with unknown causes. To predict this malignant condition in clinics is challenging. In this study, we aim to demonstra...

Authors: Haiyan Min, Shanshan Fan, Shiyu Song, Yi Zhuang, Hui Li, Yongzheng Wu, Hourong Cai, Long Yi, Jinghong Dai and Qian Gao

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT ...

Authors: Cristina Munteanu, Daniel Pirici, Alex Emilian Stepan, Adrian Camen and Claudiu Margaritescu

Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report

Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these pa...

Authors: Anna-Lena Volckmar, Volker Endris, Farastuk Bozorgmehr, Clemens Lier, Carlota Porcel, Martina Kirchner, Jonas Leichsenring, Roland Penzel, Michael Thomas, Peter Schirmacher, Arne Warth and Albrecht Stenzinger

Prognostic significance of mucin expression profiles in breast carcinoma with signet ring cells: a clinicopathological study

Signet ring cells (SRCs) often accompany gastrointestinal carcinoma, referred to as SRC carcinoma; however, breast cancers containing SRCs have not been well characterized, leaving the prognostic significance ...

Authors: Ryuji Ohashi, Ayako Hayama, Keiko Yanagihara, Koji Yamashita, Takashi Sakatani, Hiroyuki Takei and Zenya Naito

Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report

Inflammatory myofibroblastic tumor (IMT) is a rare low-grade malignant neoplasm with a predilection for children and young adults, and typically arises in the lung, abdominopelvic region, and retroperitoneum. ...

Authors: Yoko Tateishi, Koji Okudela, Shigeo Kawai, Takehisa Suzuki, Shigeaki Umeda, Mai Matsumura, Mitomu Kioi and Kenichi Ohashi

Metachronous serous endometrial intraepithelial carcinoma and serous peritoneal carcinoma: analysis of probable independent lesions

Uterine serous endometrial intraepithelial carcinoma (SEIC) is an immediate precursor of invasive carcinoma. The majority of stage IA SEICs are curable, but those with latent peritoneal metastasis and/or capil...

Authors: Mitsuko Furuya, Teiko Sato, Reiko Tanaka, Masafumi Yamamoto, Naho Ruiz Yokota and Etsuko Miyagi

Potential molecular characteristics in situ in response to repetitive UVB irradiation

To identify molecular characteristics in situ in response to repetitive UVB (ultraviolet-B) irradiation.

Authors: Wenqi Chen and Jinhai Zhang

The clinicopathological significance of angiogenesis in hindgut neuroendocrine tumors obtained via an endoscopic procedure

As the World Health Organization grading system for gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) may not always correlate with tumor progression, it is imperative that other independent predictors o...

Authors: Yoichiro Okubo, Osamu Motohashi, Norisuke Nakayama, Ken Nishimura, Rika Kasajima, Yohei Miyagi, Manabu Shiozawa, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Madoka Nito, Yoichi Kameda and Tomoyuki Yokose

Retraction note: Down-regulation of microRNA-26a and up-regulation of microRNA-27a contributes to aggressive progression of human osteosarcoma

Authors: Afshin Taheriazam, Reza Bahador, Seyyed Hasan Karbasy, Seyed Mir Mansoor Moazen Jamshidi, Ali Torkaman, Emad Yahaghi and Mohammadreza Shakeri

Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations

Authors: Ehsan Hosseini, Behnam Pedram, Ali Mohammad Bahrami, Mohammad Hossein Jaberi Moghaddam, Javad Javanbakht, Fatemeh Emami Ghomi, Najme Jaberi Moghaddam, Mobin Koohestani and Radmehr Shafiee

Retraction Note: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet

Authors: Tahereh Ebrahimi, Behnoosh Behdad, Maryam Agha Abbasi, Rahman Ghaffarzadegan Rabati, Amir Farshid Fayyaz, Vahid Behnod and Ali Asgari

Retraction Note: Clinicopathologic characterization of visceral gout of various internal organs – a study of 2 cases from a venom and toxin research center

Authors: Alireza Nasoori, Behnam Pedram, Zahra Kamyabi-Moghaddam, Aram Mokarizadeh, Hamid Pirasteh, Amir Farshid Fayyaz and Mohammad Barat Shooshtari

Retraction note: Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues

Authors: Hossein Ajdarkosh, Masoomeh Dadpay, Emad Yahaghi, Elham Rostami Pirzaman, Amir Farshid Fayyaz, Ebrahim Khodaverdi Darian and Aram Mokarizadeh

Retraction Note: Neuropathological and neuroprotective features of vitamin B₁₂ on the dorsal spinal ganglion of rats after the experimental crush of sciatic nerve: an experimental study

Authors: Rahim Hobbenaghi, Javad Javanbakht, Ehan Hosseini, Shahin Mohammadi, Mojtaba Rajabian, Pedram Moayeri and Mehdi Aghamohammad Hassan

Retraction note: Histopathological features of bone regeneration in a canine segmental ulnar defect model

Authors: Rahim Hobbenaghi, Pariya Mahboob, Siamak Saifzadeh, Javad Javanbakht, Javad Yaghoobi Yeganeh Manesh, Rasool Mortezaee, Seyed Rashid Touni, Ehsan Hosseini, Shahin Aghajanshakeri, Milad Moloudizargari and Soheil Javaherypour

Retraction note: Histopathological and clinical evaluation of Kombucha tea and Nitrofurazone on cutaneous full-thickness wounds healing in rats: an experimental study

Authors: Fardin Barati, Javad Javanbakht, Farajollah Adib-Hashemi, Ehsan Hosseini, Reyhaneh Safaeie, Mojtaba Rajabian, Mostafa Razmjoo, Reza Sedaghat and Mehdi Aghamohammad Hassan