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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  2. Glioma-associated oncogene homolog 1 (Gli1), affects the progression and the stemness characteristics of malignant carcinoma. The aim of the present study was to identify the relation between Glioma-associated...

    Authors: Wenbo Qi, Zhaoting Yang, Ying Feng, Haoyue Li, Nan Che, Lan Liu and Yanhua Xuan

    Citation: Diagnostic Pathology 2020 15:60

    Content type: Research

    Published on:

  3. A specialized classification for small biopsies was added to the 2015 WHO classification of lung tumors. The purpose of this study is to explore and summarize the experience of applying the newly proposed clas...

    Authors: Yupeng Zeng, Yunxiang Zhu, Ying Ding, Liuyang Xu, Boya Zhai, Xiang Zhang, Qiaoyun Ge, Jiao Li, Qiyuan Song, Xiao Li and Zhihong Zhang

    Citation: Diagnostic Pathology 2020 15:59

    Content type: Research

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  4. Inflammatory myofibroblastic tumors (IMTs) of the thyroid are extremely rare soft-tissue tumors. In the literature, IMTs are sometimes called plasma cell granulomas (PCGs) or inflammatory pseudotumors, which o...

    Authors: Cheng-fang Li, Xing-long Wu, Jin-jing Wang, Kai Wang, Su-yuan Zhang, Jia-jia Huang, Han-zhong Hu and Hong Zheng

    Citation: Diagnostic Pathology 2020 15:58

    Content type: Case Report

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  5. Digital multiplex gene expression profiling is overcoming the limitations of many tissue-processing and RNA extraction techniques for the reproducible and quantitative molecular classification of disease. We a...

    Authors: Jelena Vider, Andrew Croaker, Amanda J. Cox, Emma Raymond, Rebecca Rogers, Stuart Adamson, Michael Doyle, Blake O’Brien, Allan W. Cripps and Nicholas P. West

    Citation: Diagnostic Pathology 2020 15:57

    Content type: Research

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  6. Most sporadic gastrointestinal stromal tumors (GISTs) occur as solitary tumors, while multiple sporadic GISTs are extremely rare and often misdiagnosed as metastatic GISTs, leading to inappropriate treatment. ...

    Authors: Yan-Ying Shen, Xin-Li Ma, Lin-Xi Yang, Wen-Yi Zhao, Lin Tu, Chun Zhuang, Bo Ni, Qiang Liu, Ming Wang and Hui Cao

    Citation: Diagnostic Pathology 2020 15:56

    Content type: Research

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  8. Hepatocellular carcinoma (HCC) is one of the most common global malignancies with increasing morbidity and mortality. The purpose of this study was to investigate the expression levels and prognostic value of ...

    Authors: Wenwen Dou, Min Yang, Yan Su and Ruizhu Xie

    Citation: Diagnostic Pathology 2020 15:54

    Content type: Research

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  9. Chondromesenchymal hamartoma of the chest wall is a rare, benign disease that usually presents at birth or in early infancy. It typically involves one or more ribs, forming a unilateral or bilateral extrapleur...

    Authors: Yue Li, Danyang Zheng, Min Zuo, Yang Li and Huizhong Zhang

    Citation: Diagnostic Pathology 2020 15:53

    Content type: Case Report

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  10. Histologic grade of ductal carcinoma in situ of the breast (DCIS) may become the single biomarker that decides whether patients will be treated. Yet, evidence shows that grading variation in daily practice is ...

    Authors: Carmen van Dooijeweert, Paul J. van Diest, Inge O. Baas, Elsken van der Wall and Ivette A. G. Deckers

    Citation: Diagnostic Pathology 2020 15:52

    Content type: Research

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  11. Acral and cutaneous melanomas are usually difficult to accurately diagnose in the early stage, owing to the similarity in clinical manifestations and morphology with those of dysplastic nevus (DN). In this stu...

    Authors: Yumei Lai, Yan Wu, Ruping Liu, Aiping Lu, Lixin Zhou, Lin Jia, Xinting Diao and Zhongwu Li

    Citation: Diagnostic Pathology 2020 15:51

    Content type: Research

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  12. Immunotherapy has demonstrated encouraging clinical benefits in patients with advanced breast carcinomas and Programmed death ligand 1 (PD-L1) expression has been proposed as an immunotherapy biomarker. Challe...

    Authors: Ping Mei, C. Eric Freitag, Lai Wei, Yunxiang Zhang, Anil V. Parwani and Zaibo Li

    Citation: Diagnostic Pathology 2020 15:50

    Content type: Research

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  13. The objective of this study was to investigate genetic variations and the relationships between these genetic variations and clinicopathological features of high-recurrence risk papillary thyroid carcinoma in ...

    Authors: Min Li, Haitao Jia, Qiuqin Qian, Peng Wen, Chuan Chen, Yaqiong Hua, Kai Wang, Wenyong Zhang and Feng Shi

    Citation: Diagnostic Pathology 2020 15:49

    Content type: Research

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  14. Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare disorder of pulmonary vascular abnormality with persistent pulmonary hypertension of the newborn. The symptom usually prese...

    Authors: Akiko Kitano, Masato Nakaguro, Seiichi Tomotaki, Shintaro Hanaoka, Masahiko Kawai, Akiko Saito, Masahiro Hayakawa, Yoshiyuki Takahashi, Hidenori Kawasaki, Takahiro Yamada, Masahiko Ikeda, Tetsuo Onda, Kazutoshi Cho, Hironori Haga, Atsuko Nakazawa and Sachiko Minamiguchi

    Citation: Diagnostic Pathology 2020 15:48

    Content type: Case Report

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  15. Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity. D...

    Authors: Raíssa Pinheiro de Mendonça, Giordanna Pereira Chemelo, Geovanni Pereira Mitre, Dimitra Castelo Branco, Natacha Malu Miranda da Costa, Fabrício Mesquita Tuji, Maria Sueli da Silva Kataoka, Ricardo Alves Mesquita, Sérgio de Melo Alves Júnior and João de Jesus Viana Pinheiro

    Citation: Diagnostic Pathology 2020 15:47

    Content type: Research

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  16. Temporal lobe epilepsy (TLE) is the most common type of epilepsy, usually starting in childhood. The dysregulation of microRNAs (miRNAs) has been identified in neurological disorders. The current study investi...

    Authors: Na Li, Jingmei Pan, Wei Liu, Yuanyuan Li, Feng Li and Min Liu

    Citation: Diagnostic Pathology 2020 15:46

    Content type: Research

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  17. Human papillomavirus (HPV) testing has been employed by several European countries to augment cytology-based cervical screening programs. A number of research groups have demonstrated potential utility of next...

    Authors: Wai Sing Chan, Tsun Leung Chan, Chun Hang Au, Chin Pang Leung, Man Yan To, Man Kin Ng, Sau Man Leung, May Kwok Mei Chan, Edmond Shiu Kwan Ma and Bone Siu Fai Tang

    Citation: Diagnostic Pathology 2020 15:45

    Content type: Short report

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  18. Blood malignancies are among the leading causes of cancer related deaths in the world. Different environmental and genetic risk factors are involved in progression of blood malignancies. It has been shown that...

    Authors: Majid Ghayour-Mobarhan, Amir Sadra Zangouei, Seyed Mohammad Hosseinirad, Majid Mojarrad and Meysam Moghbeli

    Citation: Diagnostic Pathology 2020 15:44

    Content type: Review

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  19. Liver is one of the most common organs involved by metastatic neoplasms. In addition, a number of primary tumors can arise in the liver. Fine needle biopsy (FNB) is the most commonly used method for diagnosis ...

    Authors: Lin Zhang, Zhenjian Cai, Joe Rodriguez, Songlin Zhang, Jaiyeola Thomas and Hui Zhu

    Citation: Diagnostic Pathology 2020 15:43

    Content type: Research

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  20. The prevalence of EGFR/ALK co-alterations in patients with NSCLC was low. The several previous studies focused on the simultaneous occurrence of EGFR mutations and ALK rearrangements in a unifocal lung cancer....

    Authors: Jun Fan, Junhua Wu, Bo Huang, Yili Zhu, Heshui Shi, Xiaofang Dai and Xiu Nie

    Citation: Diagnostic Pathology 2020 15:42

    Content type: Case Report

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  21. Diversified etiology of lower respiratory tract infection renders diagnosis challenging. The mainstay microbial culture is time-consuming and constrained by variable growth requirements. In this study, we expl...

    Authors: Wai Sing Chan, Chun Hang Au, Sau Man Leung, Dona N. Ho, Elaine Yue Ling Wong, Man Yan To, Man Kin Ng, Tsun Leung Chan, Edmond Shiu Kwan Ma and Bone Siu Fai Tang

    Citation: Diagnostic Pathology 2020 15:41

    Content type: Short report

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  22. Inverted urothelial papilloma (IUP) of the upper urinary tract is an uncommon benign tumour that occasionally presents as a polypoid mass causing urinary obstruction. Histologically, IUP is characterised by a ...

    Authors: R. Santi, I. C. Galli, V. Canzonieri, J. I. Lopez and G. Nesi

    Citation: Diagnostic Pathology 2020 15:40

    Content type: Research

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  23. Progressive familial intrahepatic cholestasis (PFIC) is a rare group of autosomal recessive hereditary hepatic diseases. There are three types of PFIC, classified according to the mutated gene. For example, PF...

    Authors: Zhenping Wu, Siying Zhang, Lunli Zhang and Ming Li

    Citation: Diagnostic Pathology 2020 15:39

    Content type: Case Report

    Published on:

  24. Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues ...

    Authors: Phyoe Kyawe Myint, Eun Jeong Park, Arong Gaowa, Eiji Kawamoto and Motomu Shimaoka

    Citation: Diagnostic Pathology 2020 15:38

    Content type: Commentary

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  25. Numerous studies indicate that higher tumour programmed cell death ligand-1 (PD-L1) expression is associated with greater response to anti-programmed cell death-1 (PD-1)/PD-L1 immunotherapy in non-small cell l...

    Authors: Bharat Jasani, Gudrun Bänfer, Rebecca Fish, Wim Waelput, Yves Sucaet, Craig Barker, Jessica L. Whiteley, Jill Walker, Rudy Hovelinck and Rolf Diezko

    Citation: Diagnostic Pathology 2020 15:37

    Content type: Research

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  26. Transbronchial needle aspiration (TBNA) is a minimally invasive procedure performed to diagnose lymph node (LN) adenopathy. TBNA with and without endobronchial ultrasound (EBUS) guidance has a high diagnostic ...

    Authors: Hui Shen, Lingyun Lou, Ting Chen, Yi Zou, Bin Wang, Zhihao Xu, Qin Ye, Huahao Shen, Wen Li and Yang Xia

    Citation: Diagnostic Pathology 2020 15:36

    Content type: Research

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  28. Ulcerative colitis (UC) is one of the major types of inflammatory bowel diseases and is associated with a significantly increased risk of not only lymphoproliferative disorders but also lymphomas, of which mos...

    Authors: Kazushi Suzuki, Rintaro Ohe, Takanobu Kabasawa, Naing Ye Aung, Mitsuhiro Yano, Shuichiro Katsumi, Ryo Yanagiya, Masakazu Yamamoto, Tomomi Toubai, Kenichi Ishizawa and Mitsunori Yamakawa

    Citation: Diagnostic Pathology 2020 15:34

    Content type: Case Report

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  29. Bladder cancer (BC) is one of the most common malignancies in Egypt, representing about 8.7% of cancers in both sexes with more predominance in males, making identification of valuable predictive and prognosti...

    Authors: Dalia Rifaat Al-Sharaky, Mona Abd El-Halim Kandil, Hayam Abdel Samie Aiad, Enas Megahed El-hosary, Hagar Abdelmagied Alagizy, Mahmoud Abdel-Sattar Elshenawy and Hala Said El-Rebey

    Citation: Diagnostic Pathology 2020 15:33

    Content type: Research

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  30. Neuroendocrine tumors (NETs) can secrete bioactive amines in the bloodstream, resulting in the carcinoid syndrome characterized by diarrhea and flushing. The frequency of occurrence of primary cardiac neuroend...

    Authors: Chengfang Li, Jiajia Huang, Xiaorong Yang, Jinhua Xia, Gaoqiang Xu and Hong Zheng

    Citation: Diagnostic Pathology 2020 15:32

    Content type: Case Report

    Published on:

  32. Non-Hodgkin’s lymphoma (NHL) primarily derived from the base of the tongue, is rare. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and ...

    Authors: Xinyu Ren, Yin Cheng, Shafei Wu, Xuan Zeng, Xiaohua Shi, Qing Ling, Zongzhu Li, Zhiyong Liang and Beverly Wang

    Citation: Diagnostic Pathology 2020 15:30

    Content type: Research

    Published on:

  34. To investigate the expression and function of RSK4, MMP-9 and CD44 in primary clear cell renal cell carcinoma (primary ccRCC) and metastatic clear cell renal cell carcinoma (metastatic ccRCC), as well as the c...

    Authors: Jing Ma, Mingyang Li, Jia Chai, Kaijing Wang, Peifeng Li, Yixiong Liu, Danhui Zhao, Junpeng Xu, Kangjie Yu, Qingguo Yan, Shuangping Guo, Zhe Wang and Linni Fan

    Citation: Diagnostic Pathology 2020 15:28

    Content type: Research

    Published on:

  35. Despite great progress in surgery and other treatments, the prognosis of patients with esophageal squamous cell carcinoma (ESCC) is still very poor. HER2 has strong therapeutic implications in certain cancers,...

    Authors: Lulu Rong, Bingzhi Wang, Lei Guo, Xiuyun Liu, Bingning Wang, Jianming Ying, Liyan Xue and Ning Lu

    Citation: Diagnostic Pathology 2020 15:27

    Content type: Research

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  36. Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF...

    Authors: Misuzu Okabayshi, Tatsuki R. Kataoka, Marina Oji, Satoko Mibayashi, Kentaro Odani, Atsushi Otsuka and Hironori Haga

    Citation: Diagnostic Pathology 2020 15:26

    Content type: Research

    Published on:

  39. Low-grade fibromyxoid sarcoma (LGFMS) is a rare fibroblastic tumor often involving deep tissue of trunk and lower extremities in young to middle-aged patients. Rarely, LGFMS can occur in other sites including ...

    Authors: Jialing Huang, Steven Cohen and Gerorge Jour

    Citation: Diagnostic Pathology 2020 15:23

    Content type: Case Report

    Published on:

  40. Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors.

    Authors: Rui-Yue Hu, Yan-Juan Deng, Hao-Hao Zhu, Jing Zhou, Ming Hu, Xiao-Qing Liang, Qiu-Jin Xiao, Lv Zhou, Xiao-Yu Peng, Xing-Wei Zhang, Ning Ji and Huan Deng

    Citation: Diagnostic Pathology 2020 15:22

    Content type: Case Report

    Published on:

  41. There is minimal information regarding the prevalence of intratumoral adipose in renal cell carcinoma (RCC), and no study has assessed the impact of intratumoral adipose on the preoperative imaging diagnosis. ...

    Authors: Zhaoying Xian, Jason O. Orien, Geoffrey N. Box and Debra L. Zynger

    Citation: Diagnostic Pathology 2020 15:21

    Content type: Research

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  42. We report an unusual case of low-grade fibromatosis-like metaplastic carcinoma (LG-FLMC) of the breast. This exceedingly rare epithelial breast malignancy has been reported only 68 times in the past 20 years, ...

    Authors: Jasper Victoor, Claire Bourgain, Sara Vander Borght, Isabelle Vanden Bempt, Carine De Rop and Giuseppe Floris

    Citation: Diagnostic Pathology 2020 15:20

    Content type: Case Report

    Published on:

  43. MicroRNAs (miRNAs) have been investigated in various cardiovascular diseases. As a fatal disease, acute myocardial infarction (AMI) is a serious global health burden. The purpose of this study was to investiga...

    Authors: Yunxiang Dai, Tingguo Yan and Yuming Gao

    Citation: Diagnostic Pathology 2020 15:19

    Content type: Research

    Published on:

  44. Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to b...

    Authors: Fangxiao Cheng, Geheng Yuan, Jiao He, Yimin Shao, Junqing Zhang and Xiaohui Guo

    Citation: Diagnostic Pathology 2020 15:18

    Content type: Research

    Published on:

  45. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a standard procedure used to obtain tissue samples for diagnosis of solid retroperitoneal tumours. However, this procedure demands high technica...

    Authors: Jian-Han Lai, Hsiang-Hung Lin and Ching-Chung Lin

    Citation: Diagnostic Pathology 2020 15:17

    Content type: Research

    Published on:

  46. Papillary thyroid carcinoma (PTC) is an indolent tumor that is exploding with increasing thyroid nodules (TN). Environmental carcinogens, lifestyle changes increased the incidence of thyroid carcinoma. With th...

    Authors: Hongsheng Lu, Lihong Zhang, Yuechu Dai, Yanyun Ruan, Xuequan Cao, Xiaobo Cai, Sihan Ruan and Qi Chen

    Citation: Diagnostic Pathology 2020 15:16

    Content type: Research

    Published on:

  47. Primary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma that is characterized in most cases by recurrent balanced chromosomal translocation t(2;22)(q33;q12) leading to the oncogenic fusion gene

    Authors: Zhenwei Chen, Yihui Yang, Rongming Chen, Chi Sing Ng and Hongqi Shi

    Citation: Diagnostic Pathology 2020 15:15

    Content type: Case Report

    Published on:

  48. To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry).

    Authors: Lili Cheng, Qi Wang, Xiaoying Tao, Yanzi Qin, Qiong Wu, Dafang Zheng, Damin Chai, Yong Zhang, Dongbing Lu, Hongfei Ci, Zhiwei Wang, Jia Ma, Danna Wang, Zenong Cheng, Shiwu Wu and Yisheng Tao

    Citation: Diagnostic Pathology 2020 15:14

    Content type: Research

    Published on:

  49. Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease.

    Authors: Toshitetsu Hayashi, Mitsuyoshi Hirokawa, Seiji Kuma, Miyoko Higuchi, Ayana Suzuki, Risa Kanematsu, Takumi Kudo, Naomi Katsuki, Reiji Haba and Akira Miyauchi

    Citation: Diagnostic Pathology 2020 15:13

    Content type: Case Report

    Published on:

  50. Squamous cell carcinoma is the most common malignant tumor of the uterine cervix with a well-documented link to infection with human papillomaviruses (HPV). According to a recent classification, there are seve...

    Authors: Jan Hrudka, Blanka Rosová and Michael J. Halaška

    Citation: Diagnostic Pathology 2020 15:12

    Content type: Case Report

    Published on:

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