Hartke J, Johnson M, Ghabril M. The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol. 2017;34(2):153–9. https://doi.org/10.1053/j.semdp.2016.12.011.
Article
PubMed
Google Scholar
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492.
Article
PubMed
Google Scholar
Marengo A, Rosso C, Bugianesi E. Liver Cancer: connections with obesity, fatty liver, and cirrhosis. Annu Rev Med. 2016;67(1):103–17. https://doi.org/10.1146/annurev-med-090514-013832.
Article
CAS
PubMed
Google Scholar
de Martel C, Maucort-Boulch D, Plummer M, Franceschi S. World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 2015;62(4):1190–200.
Article
PubMed
Google Scholar
Chedid MF, Kruel CR, Pinto MA, Grezzana-Filho TJ, Leipnitz I, Kruel CD, et al. Hepatocellular carcinoma: diagnosis and operative management. Braz Arch Digest Surg. 2017;30(4):272–8.
Google Scholar
Shen Z, Li M, Bai S, Yang Q, Zhang F, Tang M, et al. [Progress in immunotherapy for hepatocellular carcinoma]. Sheng wu gong cheng xue bao =. Chin J Biotechnol. 2019;35(12):2326–38. https://doi.org/10.13345/j.cjb.190339.
Article
Google Scholar
Bremnes RM, Al-Shibli K, Donnem T, Sirera R, Al-Saad S, Andersen S, et al. The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer. J Thorac Oncol. 2011;6(4):824–33. https://doi.org/10.1097/JTO.0b013e3182037b76.
Article
PubMed
Google Scholar
Choi Y, Kim JW. Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer. Gastric Cancer. 2017;20(4):602–11. https://doi.org/10.1007/s10120-016-0642-0.
Article
CAS
PubMed
Google Scholar
Angell HK, Lee J, Kim KM, Kim K, Kim ST, Park SH, et al. PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer. Oncoimmunology. 2019;8(2):e1544442. https://doi.org/10.1080/2162402X.2018.1544442.
Article
CAS
PubMed
Google Scholar
Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, et al. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017;114(28):7414–9. https://doi.org/10.1073/pnas.1703577114.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pagès F, Galon J, Dieu-Nosjean MC, Tartour E, Sautès-Fridman C, Fridman WH. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene. 2010;29(8):1093–102. https://doi.org/10.1038/onc.2009.416.
Article
CAS
PubMed
Google Scholar
Zhang S, Zhang E, Long J, Hu Z, Peng J, Liu L, et al. Immune infiltration in renal cell carcinoma. Cancer Sci. 2019;110(5):1564–72. https://doi.org/10.1111/cas.13996.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ye L, Li Y, Tang H, Liu W, Chen Y, Dai T, et al. CD8+CXCR5+T cells infiltrating hepatocellular carcinomas are activated and predictive of a better prognosis. Aging. 2019;11(20):8879–91. https://doi.org/10.18632/aging.102308.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moeini A, Torrecilla S, Tovar V, Montironi C, Andreu-Oller C, Peix J, et al. An immune gene expression signature associated with development of human Hepatocellular Carcinoma identifies mice that respond to chemopreventive agents. Gastroenterology. 2019;157(5):1383–97.e11.
Article
CAS
PubMed
Google Scholar
Long J, Wang A, Bai Y, Lin J, Yang X, Wang D, et al. Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma. EBioMedicine. 2019;42:363–74. https://doi.org/10.1016/j.ebiom.2019.03.022.
Article
PubMed
PubMed Central
Google Scholar
Wu X, Gu Z, Chen Y, Chen B, Chen W, Weng L, et al. Application of PD-1 blockade in Cancer immunotherapy. Comput Struct Biotechnol J. 2019;17:661–74. https://doi.org/10.1016/j.csbj.2019.03.006.
Article
CAS
PubMed
PubMed Central
Google Scholar
van IJzendoorn DG, Szuhai K, et al. Machine learning analysis of gene expression data reveals novel diagnostic and prognostic biomarkers and identifies therapeutic targets for soft tissue sarcomas. PLoS Comput Biol. 2019;15(2):e1006826.
Article
PubMed
PubMed Central
Google Scholar
Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559. https://doi.org/10.1186/1471-2105-9-559.
Article
CAS
PubMed
PubMed Central
Google Scholar
Newman AM, Liu CL, Green MR. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li R, Qu H, Wang S, Wei J, Zhang L, Ma R, et al. GDCRNATools: an R/Bioconductor package for integrative analysis of lncRNA, miRNA and mRNA data in GDC. Bioinformatics. 2018;34(14):2515–7.
Article
CAS
PubMed
Google Scholar
Bosetti C, Turati F, La Vecchia C. Hepatocellular carcinoma epidemiology. Best Pract Res Clin Gastroenterol. 2014;28(5):753–70. https://doi.org/10.1016/j.bpg.2014.08.007.
Article
PubMed
Google Scholar
Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30(1):207–10. https://doi.org/10.1093/nar/30.1.207.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–e10. https://doi.org/10.1158/0008-5472.CAN-17-0307.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ru B, Wong CN, Tong Y, Zhong JY, Zhong SSW, Wu WC, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35(20):4200–2.
Article
CAS
PubMed
Google Scholar
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
Article
PubMed
PubMed Central
Google Scholar
Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–w102. https://doi.org/10.1093/nar/gkx247.
Article
CAS
PubMed
PubMed Central
Google Scholar
Piñeiro Fernández J, Luddy KA, Harmon C, O'Farrelly C. Hepatic Tumor Microenvironments and effects on NK Cell Phenotype and function. Int J Mol Sci. 2019;20(17):4131.
Article
PubMed Central
Google Scholar
Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, et al. Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology. 2015;4(4):e998538. https://doi.org/10.1080/2162402X.2014.998538.
Article
CAS
PubMed
PubMed Central
Google Scholar
Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960–4.
Article
CAS
PubMed
Google Scholar
Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Grainge MJ, Lee AH, et al. Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol. 2011;29(15):1949–55. https://doi.org/10.1200/JCO.2010.30.5037.
Article
PubMed
Google Scholar
Sharma P, Shen Y, Wen S, Yamada S, Jungbluth AA, Gnjatic S, et al. CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci U S A. 2007;104(10):3967–72. https://doi.org/10.1073/pnas.0611618104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li Z, Chen G, Cai Z, Dong X, Qiu L, Xu H, et al. Genomic and transcriptional Profiling of tumor infiltrated CD8(+) T cells revealed functional heterogeneity of antitumor immunity in hepatocellular carcinoma. Oncoimmunology. 2019;8(2):e1538436.
Article
PubMed
Google Scholar
Huang CY, Wang Y, Luo GY, Han F, Li YQ, Zhou ZG, et al. Relationship Between PD-L1 Expression and CD8+ T-cell Immune Responses in Hepatocellular Carcinoma. J Immunother. 2017;40(9):323–33.
Article
CAS
PubMed
Google Scholar
Xu X, Tan Y, Qian Y, Xue W, Wang Y, Du J, et al. Clinicopathologic and prognostic significance of tumor-infiltrating CD8+ T cells in patients with hepatocellular carcinoma: a meta-analysis. Medicine. 2019;98(2):e13923. https://doi.org/10.1097/MD.0000000000013923.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bommhardt U, Schraven B, Simeoni L. Beyond TCR signaling: emerging functions of Lck in Cancer and Immunotherapy. Int J Mol Sci. 2019;20(14):3500.
Article
CAS
PubMed Central
Google Scholar
Katayama MLH, Vieira R, Andrade VP, Roela RA, Lima L, Kerr LM, et al. Stromal cell signature associated with response to Neoadjuvant Chemotherapy in locally advanced Breast cancer. Cells. 2019;8(12):1556.
Article
Google Scholar
Hinchcliff E, Paquette C, Roszik J, Kelting S, Stoler MH, Mok SC, et al. Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature. Cancer Immunol Immunother. 2019;68(9):1515–26. https://doi.org/10.1007/s00262-019-02385-x.
Article
CAS
PubMed
Google Scholar
Akbani R, Akdemir KC, Aksoy BA, et al. Genomic Classification of Cutaneous Melanoma. Cell. 2015;161(7):1681–96.
Article
Google Scholar
Zepecki JP, Snyder KM. Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor. Oncogene. 2019;38(10):1734–50.
Article
CAS
PubMed
Google Scholar
Fujimoto Y, Inoue N, Morimoto K, Watanabe T, Hirota S, Imamura M, et al. Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer. Cancer Sci. 2020;111(1):209–18.
Article
CAS
PubMed
Google Scholar
Lin J, Yu M, Xu X, Wang Y, Xing H, An J, et al. Identification of biomarkers related to CD8(+) T cell infiltration with gene co-expression network in clear cell renal cell carcinoma. Aging. 2020;12(4):3694–712. https://doi.org/10.18632/aging.102841.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dangaj D, Bruand M, Grimm AJ, Ronet C, Barras D, Duttagupta PA, et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. 2019;35(6):885–900.e10.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fan W, Ye G. Microarray analysis for the identification of specific proteins and functional modules involved in the process of hepatocellular carcinoma originating from cirrhotic liver. Mol Med Rep. 2018;17(4):5619–26. https://doi.org/10.3892/mmr.2018.8555.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chang Y, Zhou L, Xu L, Fu Q, Yang Y, Lin Z, et al. High expression of CXC chemokine receptor 6 associates with poor prognosis in patients with clear cell renal cell carcinoma. Urol Oncol. 2017;35(12):675.e17–24.
Article
CAS
Google Scholar
Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, et al. CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4(+) T-Cell-Dependent Control of Senescence. Gastroenterology. 2019;156(6):1877–89.e4.
Article
PubMed
Google Scholar
Liepelt A, Wehr A, Kohlhepp M, Mossanen JC, Kreggenwinkel K, Denecke B, et al. CXCR6 protects from inflammation and fibrosis in NEMO (LPC-KO) mice. Biochim et Biophys Acta Mol Basis Dis. 2019;1865(2):391–402. https://doi.org/10.1016/j.bbadis.2018.11.020.
Article
CAS
Google Scholar
Firtina S, Ng YY, Ng OH, Nepesov S, Yesilbas O, Kilercik M, et al. A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey. Immunogenetics. 2017;69(10):653–9.
Article
CAS
PubMed
Google Scholar
Zhuang H, Zhang C, Hou B. FAM83H overexpression predicts worse prognosis and correlates with less CD8(+) T cells infiltration and Ras-PI3K-Akt-mTOR signaling pathway in pancreatic cancer. Clin Transl Oncol. 2020;22(12):2244–52.
Article
CAS
PubMed
Google Scholar
Lecerf C, Kamal M, Vacher S, Chemlali W, Schnitzler A, Morel C, et al. Immune gene expression in head and neck squamous cell carcinoma patients. Eur J Cancer. 2019;121:210–23.
Article
CAS
PubMed
Google Scholar