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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. Ductal carcinoma of the prostate is a histological subtype with a higher mortality than acinar adenocarcinoma. The number of cases is small and there are no treatment guidelines. We believe that this is the fi...

    Authors: Kota Umeda, Takeo Kosaka, Kohei Nakamura, Toshikazu Takeda, Shuji Mikami, Hiroshi Nishihara and Mototsugu Oya

    Citation: Diagnostic Pathology 2020 15:102

    Content type: Case Report

    Published on:

  2. MicroRNAs (miRNAs) serve as novel promising biomarkers for the diagnosis and prognosis of many human diseases. This study investigated the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosi...

    Authors: Weibo Lv, Tao Zhang, Hongwei Zhao, Shuang He, Bingwei Li, Yang Gao and Wenying Pan

    Citation: Diagnostic Pathology 2020 15:101

    Content type: Research

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  3. Multiplex immunohistochemistry (mIHC) permits the labeling of six or more distinct cell types within a single histologic tissue section. The classification of each cell type requires detection of the unique co...

    Authors: Danielle J. Fassler, Shahira Abousamra, Rajarsi Gupta, Chao Chen, Maozheng Zhao, David Paredes, Syeda Areeha Batool, Beatrice S. Knudsen, Luisa Escobar-Hoyos, Kenneth R. Shroyer, Dimitris Samaras, Tahsin Kurc and Joel Saltz

    Citation: Diagnostic Pathology 2020 15:100

    Content type: Research

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  4. Molecular diagnostics can be decisive in the differential diagnosis between a somatic metastasis of type II testicular germ cell tumor (TGCT) or a second primary carcinoma. This is in line with recent recommen...

    Authors: Mariëtte E. G. Kranendonk, Wenzel M. Hackeng, G. Johan A. Offerhaus, Folkert H. M. Morsink, Geertruida N. Jonges, Gerard Groenewegen, Pieter-Jaap Krijtenburg, Heinz-Josef Klümpen, Wendy W. J. de Leng, Leendert H. J. Looijenga and Lodewijk A. A. Brosens

    Citation: Diagnostic Pathology 2020 15:99

    Content type: Case Report

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  5. Fibro-adipose vascular anomaly (FAVA) is a new entity of vascular anomalies with somatic and mosaic gain-of-function mutations of the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3C...

    Authors: Yumiko Hori, Katsutoshi Hirose, Noriko Aramaki-Hattori, Sachi Suzuki, Robert Nakayama, Masanori Inoue, Takahiro Matsui, Masaharu Kohara, Satoru Toyosawa and Eiichi Morii

    Citation: Diagnostic Pathology 2020 15:98

    Content type: Case Report

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  6. Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of...

    Authors: Michael Lee, Huaibin Mabel Ko, Anthony Rubino, Hwajeong Lee, Ryan Gill and Stephen M. Lagana

    Citation: Diagnostic Pathology 2020 15:97

    Content type: Research

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  7. Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the ex...

    Authors: Chunlei Liu and Xiuling Yi

    Citation: Diagnostic Pathology 2020 15:96

    Content type: Research

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  8. Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm seen in children and young adults, usually manifested by involvement of abdominal serosa. Here, we present an unusual case of primary ...

    Authors: Dilek Ertoy Baydar, Ayse Armutlu, Oguz Aydin, Ayhan Dagdemir and Yarkin Kamil Yakupoglu

    Citation: Diagnostic Pathology 2020 15:95

    Content type: Case Report

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  9. Bladder cancer (BC) is a common and deadly disease. Over the past decade, a number of genetic alterations have been reported in BC. Bladder urothelium expresses abundant urea transporter UT-B encoded by Slc14a1 g...

    Authors: Zhongying Guo, Xiaobing Niu, Guangbo Fu, Baoxue Yang, Guangping Chen and Su’an Sun

    Citation: Diagnostic Pathology 2020 15:94

    Content type: Case Report

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  10. Patients with 46, XY disorder of sex development (DSD) are predisposed to the development of gonadal tumors, particularly germ cell tumors and gonadoblastoma. However, to the best of our knowledge, there are n...

    Authors: Jiangying Zhao, Jiao Peng, Sisi He, Jia Yang and Xiaojun Pang

    Citation: Diagnostic Pathology 2020 15:93

    Content type: Case Report

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  11. Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common ...

    Authors: Pavel Dundr, Mária Gregová, Kristýna Němejcová, Michaela Bártů, Nikola Hájková, Jan Hojný, Ivana Stružinská and Daniela Fischerová

    Citation: Diagnostic Pathology 2020 15:91

    Content type: Case Report

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  12. Takotsubo cardiomyopathy is characterized by transient dysfunction of the medial to apical segment of the left ventricle. Recurrence within a few months or years has been reported and serious complications, in...

    Authors: Kenichi Mizutani, Akihiro Shioya, Yasuyo Hirose, Ryuhei Saito and Sohsuke Yamada

    Citation: Diagnostic Pathology 2020 15:90

    Content type: Case Report

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  13. Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor. In addition to the main ATC type with classical histopathological features, the other morphological types of ATC include paucicellular variant, ang...

    Authors: Jixuan Liu, Ni Cui, Wenjia Ding, Xinjie Dong, Xiaoshuai Chen, Jun Jiang and Yafang Liu

    Citation: Diagnostic Pathology 2020 15:89

    Content type: Case Report

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  14. Malacoplakia is a rare chronic inflammatory disease. The name derives from the Greek “μαλακός” meaning “soft” and “πλάξ” meaning “plaque”, describing its usual macroscopic presentation as a friable yellow soft pl...

    Authors: Antonio d’Amati, Emilio Bellitti and Leonardo Resta

    Citation: Diagnostic Pathology 2020 15:88

    Content type: Case Report

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  15. Identification of bladder layers is a necessary prerequisite to bladder cancer diagnosis and prognosis. We present a method of multi-class image segmentation, which recognizes urothelium, lamina propria, muscu...

    Authors: Muhammad Khalid Khan Niazi, Enes Yazgan, Thomas E. Tavolara, Wencheng Li, Cheryl T. Lee, Anil Parwani and Metin N. Gurcan

    Citation: Diagnostic Pathology 2020 15:87

    Content type: Research

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  16. Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be cha...

    Authors: Peter F. Rambau, Martin Köbel, Derek Tilley, Alex Mremi, Robert Lukande and William Muller

    Citation: Diagnostic Pathology 2020 15:86

    Content type: Research

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  17. Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with in...

    Authors: Esther Moreno, Juan M. Rosa-Rosa, Tamara Caniego-Casas, Ignacio Ruz-Caracuel, Cristian Perna, Carmen Guillén and José Palacios

    Citation: Diagnostic Pathology 2020 15:84

    Content type: Case Report

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  18. E-cigarette and vaping use-associated acute lung injury (EVALI) has been recently recognized as a complication in individuals who use vaping devices. Another consideration is that EVALI may have an adverse inf...

    Authors: Bindu H. Akkanti, Rahat Hussain, Manish K. Patel, Jayeshkumar A. Patel, Kha Dinh, Bihong Zhao, Shaimaa Elzamly, Kevin Pelicon, Klemen Petek, Ismael A. Salas de Armas, Mehmet Akay, Biswajit Kar, Igor D. Gregoric and L. Maximilian Buja

    Citation: Diagnostic Pathology 2020 15:83

    Content type: Case Report

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  19. Primary intestinal follicular lymphoma (PI-FL) is a rare and indolent lymphoma and is challenging for diagnosis with endoscopic biopsy specimens. Whole slide imaging (WSI) has been increasingly used for assist...

    Authors: Hsin-Ni Li, Ren Ching Wang, Jun-Peng Chen, Sheng-Tsung Chang and Shih-Sung Chuang

    Citation: Diagnostic Pathology 2020 15:82

    Content type: Research

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  20. Pathologists frequently encounter neuroendocrine tumors (NETs) presenting as multiple liver masses in routine practice. Most often, these are well-differentiated tumors with characteristic histologic features....

    Authors: Elise R. Venable, Sarah E. Kerr, M. Beatriz S. Lopes, Karra A. Jones, Andrew M. Bellizzi, Taofic Mounajjed, Aditya Raghunathan, Oksana Hamidi, Thorvardur R. Halfdanarson, Mabel Ryder and Rondell P. Graham

    Citation: Diagnostic Pathology 2020 15:81

    Content type: Research

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  21. The mitotic count in breast carcinoma is an important prognostic marker. Unfortunately substantial inter- and intra-laboratory variation exists when pathologists manually count mitotic figures. Artificial inte...

    Authors: Liron Pantanowitz, Douglas Hartman, Yan Qi, Eun Yoon Cho, Beomseok Suh, Kyunghyun Paeng, Rajiv Dhir, Pamela Michelow, Scott Hazelhurst, Sang Yong Song and Soo Youn Cho

    Citation: Diagnostic Pathology 2020 15:80

    Content type: Research

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  22. Without early recognition and Kasai procedure, biliary atresia (BA) results in liver cirrhosis and leads to either transplantation or death at a young age. We aimed to characterize the liver histopathological ...

    Authors: Gunadi, Dian Nirmala Sirait, Leila Rakhma Budiarti, Vincentia Meta Widya Paramita, Aditya Rifqi Fauzi, Fiko Ryantono, Dwiki Afandy, Naomi Yoshuantari, Hanggoro Tri Rinonce and Akhmad Makhmudi

    Citation: Diagnostic Pathology 2020 15:79

    Content type: Research

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  23. The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 ...

    Authors: Pan Zhai, Yanbing Ding and Yiming Li

    Citation: Diagnostic Pathology 2020 15:78

    Content type: Case Report

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  24. This study evaluated the predictive power of Atyp.C (a parameter of UF-5000 flow cytometer) for patients with a suspected diagnosis of urothelial carcinoma.

    Authors: Chunyun Ren, Xing Wang, Chunwei Yang, Shengchao Li, Shuangchun Liu and Hongcui Cao

    Citation: Diagnostic Pathology 2020 15:77

    Content type: Research

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  25. We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopatholo...

    Authors: Yuri Akishima-Fukasawa, Naoko Honma, Hideaki Ogata, Yoshikiyo Akasaka and Tetuo Mikami

    Citation: Diagnostic Pathology 2020 15:75

    Content type: Research

    Published on:

  26. Early diagnosis of asymptomatic carotid artery stenosis (ACAS) is important to prevent the incidence of cerebrovascular events. This study aimed to investigate the circulating expression of microRNA-92a (miR-9...

    Authors: Gang Chen, Jianwei Gao, Yuguo Sheng, Xinqiang Han, Xingang Ji, Mengpeng Zhao and Jian Wu

    Citation: Diagnostic Pathology 2020 15:74

    Content type: Research

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  27. In lung cancer patients infected with COVID-19, pathological features are not easy to distinguish. This report presents detailed histopathological findings in two non-neoplastic subjects whose out-of-hospital ...

    Authors: Roberto Scendoni, Francesca Marchesani, Nunzia Cannovo, Piergiorgio Fedeli and Mariano Cingolani

    Citation: Diagnostic Pathology 2020 15:73

    Content type: Commentary

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  28. Intravascular large B-cell lymphoma (IVLBCL) is an extremely rare subtype of diffuse large B-cell lymphoma that most commonly involves the central nervous system, skin, and bone marrow. To our knowledge, Epste...

    Authors: Qingjiao Li, Jinghe Li, Keda Yang, Ying Peng, Yao Xiang, Shuyuan Sun, Jian Zeng, Xin Zhang and Junpu Wang

    Citation: Diagnostic Pathology 2020 15:72

    Content type: Case Report

    Published on:

  29. Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted thera...

    Authors: Xiaohong Xie, Xinqing Lin, Ming Liu, Yinyin Qin, Ming Ouyang, Shiyue Li, Yingying Gu, Shuyin Chen, Jianxing Xiang and Chengzhi Zhou

    Citation: Diagnostic Pathology 2020 15:71

    Content type: Case Report

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  30. The prognostic potential of PD-L1 is currently unclear in gastric carcinomas, although the immune checkpoint PD-1/PD-L1 inhibitors have produced promising results in clinical trials.

    Authors: Euno Choi, Mee Soo Chang, Sun-ju Byeon, Heejin Jin, Kyeong Cheon Jung, Haeryoung Kim, Kook Lae Lee, Won Kim, Jin Hyun Park, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Dong-Seok Han, Hye Seong Ahn and Seung Chul Heo

    Citation: Diagnostic Pathology 2020 15:69

    Content type: Research

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  31. Yolk sac tumor (YST) is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These latter cases have been documented in several or...

    Authors: Nadia Espejo-Herrera and Enric Condom-Mundó

    Citation: Diagnostic Pathology 2020 15:68

    Content type: Case Report

    Published on:

  32. The scoring of Ki-67 is highly relevant for the diagnosis, classification, prognosis, and treatment in breast invasive ductal carcinoma (IDC). Traditional scoring method of Ki-67 staining followed by manual co...

    Authors: Min Feng, Yang Deng, Libo Yang, Qiuyang Jing, Zhang Zhang, Lian Xu, Xiaoxia Wei, Yanyan Zhou, Diwei Wu, Fei Xiang, Yizhe Wang, Ji Bao and Hong Bu

    Citation: Diagnostic Pathology 2020 15:65

    Content type: Research

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  33. Bartholin gland carcinomas (BGCs) are rare tumor types, for which no molecular analyses including genomic sequencing have been reported to date. Adenoid cystic carcinomas (ACCs) of the Bartholin’s glands are a...

    Authors: Kohei Nakamura, Eriko Aimono, Shigeki Tanishima, Hidetaka Nomura, Mitsuho Imai, Hideyuki Hayashi and Hiroshi Nishihara

    Citation: Diagnostic Pathology 2020 15:64

    Content type: Case Report

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  34. Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationsh...

    Authors: Sung Woo Ahn, Ae-Ri Ahn, Sang Hoon Ha, Usama Khamis Hussein, Jae Do Yang, Kyoung Min Kim, Ho Sung Park, See-Hyoung Park, Hee Chul Yu and Kyu Yun Jang

    Citation: Diagnostic Pathology 2020 15:63

    Content type: Research

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  35. Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it is increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially in Europe....

    Authors: Elodie Miquelestorena-Standley, Charlotte Jaulerry, Marie-Christine Machet, Nolwenn Rabot, Christelle Barbet, Aurélie Hummel, Alexandre Karras, Cyril Garrouste, Thomas Crepin, Didier Ducloux, Maud Cousin, Catherine Albert, Joseph Rivalan, Emilie Cornec-Le Gall, François Pourreau, Clément Deltombe…

    Citation: Diagnostic Pathology 2020 15:62

    Content type: Research

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  36. Glioma-associated oncogene homolog 1 (Gli1), affects the progression and the stemness characteristics of malignant carcinoma. The aim of the present study was to identify the relation between Glioma-associated...

    Authors: Wenbo Qi, Zhaoting Yang, Ying Feng, Haoyue Li, Nan Che, Lan Liu and Yanhua Xuan

    Citation: Diagnostic Pathology 2020 15:60

    Content type: Research

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  37. A specialized classification for small biopsies was added to the 2015 WHO classification of lung tumors. The purpose of this study is to explore and summarize the experience of applying the newly proposed clas...

    Authors: Yupeng Zeng, Yunxiang Zhu, Ying Ding, Liuyang Xu, Boya Zhai, Xiang Zhang, Qiaoyun Ge, Jiao Li, Qiyuan Song, Xiao Li and Zhihong Zhang

    Citation: Diagnostic Pathology 2020 15:59

    Content type: Research

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  38. Inflammatory myofibroblastic tumors (IMTs) of the thyroid are extremely rare soft-tissue tumors. In the literature, IMTs are sometimes called plasma cell granulomas (PCGs) or inflammatory pseudotumors, which o...

    Authors: Cheng-fang Li, Xing-long Wu, Jin-jing Wang, Kai Wang, Su-yuan Zhang, Jia-jia Huang, Han-zhong Hu and Hong Zheng

    Citation: Diagnostic Pathology 2020 15:58

    Content type: Case Report

    Published on:

  39. Digital multiplex gene expression profiling is overcoming the limitations of many tissue-processing and RNA extraction techniques for the reproducible and quantitative molecular classification of disease. We a...

    Authors: Jelena Vider, Andrew Croaker, Amanda J. Cox, Emma Raymond, Rebecca Rogers, Stuart Adamson, Michael Doyle, Blake O’Brien, Allan W. Cripps and Nicholas P. West

    Citation: Diagnostic Pathology 2020 15:57

    Content type: Research

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  40. Most sporadic gastrointestinal stromal tumors (GISTs) occur as solitary tumors, while multiple sporadic GISTs are extremely rare and often misdiagnosed as metastatic GISTs, leading to inappropriate treatment. ...

    Authors: Yan-Ying Shen, Xin-Li Ma, Lin-Xi Yang, Wen-Yi Zhao, Lin Tu, Chun Zhuang, Bo Ni, Qiang Liu, Ming Wang and Hui Cao

    Citation: Diagnostic Pathology 2020 15:56

    Content type: Research

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  41. Hepatocellular carcinoma (HCC) is one of the most common global malignancies with increasing morbidity and mortality. The purpose of this study was to investigate the expression levels and prognostic value of ...

    Authors: Wenwen Dou, Min Yang, Yan Su and Ruizhu Xie

    Citation: Diagnostic Pathology 2020 15:54

    Content type: Research

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  42. Chondromesenchymal hamartoma of the chest wall is a rare, benign disease that usually presents at birth or in early infancy. It typically involves one or more ribs, forming a unilateral or bilateral extrapleur...

    Authors: Yue Li, Danyang Zheng, Min Zuo, Yang Li and Huizhong Zhang

    Citation: Diagnostic Pathology 2020 15:53

    Content type: Case Report

    Published on:

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