Articles

Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3

Lung cancer (LC) is a malignant tumor originating in the bronchial mucosa or gland of the lung. Circular RNAs (circRNAs) are proved to be key regulators of tumor progression. However, the regulatory effect of ...

Authors: Koudong Zhang, Hang Hu, Juan Xu, Limin Qiu, Haitao Chen, Xingzhi Jiang and Yongqian Jiang

Giant lung metastasis of NRAS-mutant melanoma in a 24-year-old patient with a history of BRAF-mutant conventional melanoma harboring Spitzoid morphology: a case report

Spitzoid melanocytic lesions represent a heterogeneous group of proliferations with ambiguous and overlapping terminology. The exact distinction of a Spitz nevus from a Spitzoid melanoma can be very difficult ...

Authors: Jiri Vachtenheim Jr, Roman Kodet, Ondrej Fischer, Vitezslav Kolek, Zuzana Strizova, Andrej Ozaniak, Jan Simonek, Alan Stolz, Jiri Pozniak, Jan Kolarik, Monika Svorcova, Jiri Vachtenheim and Robert Lischke

Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection

Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the ...

Authors: Chengfang Li, Xinglong Wu, Shuang Yang, Xiaorong Yang, Jin Yao and Hong Zheng

Detection and stage classification of Plasmodium falciparum from images of Giemsa stained thin blood films using random forest classifiers

The conventional method for the diagnosis of malaria parasites is the microscopic examination of stained blood films, which is time consuming and requires expertise. We introduce computer-based image segmentat...

Authors: Syed Saiden Abbas and Tjeerd M. H. Dijkstra

Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension

Histologic features of idiopathic non-cirrhotic portal hypertension (INCPH) may overlap with those without INCPH. Recently, these features have been recognized as part of the larger spectrum of porto-sinusoida...

Authors: Michel Kmeid, Chunlai Zuo, Stephen M. Lagana, Won-Tak Choi, Jingmei Lin, Zhaohai Yang, Xiuli Liu, Maria Westerhoff, M. Isabel Fiel, Kajsa Affolter, Eun-Young K. Choi and Hwajeong Lee

Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma

Colorectal T/natural killer (NK)-cell lymphomas (TNKCL) are very rare. Endoscopic and clinicopathological characteristics of colorectal TNKCL have not been clearly demonstrated. In this study, we demonstrated ...

Authors: Hideki Ishibashi, Satoshi Nimura, Fumihito Hirai, Naohiko Harada, Hiromi Iwasaki, Sigeto Kawauchi, Yumi Oshiro, Atsuji Matsuyama, Shotaro Nakamura, Yasushi Takamatsu, Hirotoshi Yonemasu, Taturo Shimokama and Morishige Takeshita

Diagnostic value of clusterin immunostaining in hepatocellular carcinoma

Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenge. Existing biomarkers are of limited diagnostic value. Our previous ...

Authors: Yuan Li, Fangfang Liu, Wendi Zhou, Sharon Zhang, Peiguo Chu, Fan Lin and Hanlin L. Wang

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenes...

Authors: Hong Kyu Lee, Mi Jung Kwon, Yong Joon Ra, Hee Sung Lee, Hyoung Soo Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Kyueng-Whan Min and So Young Kang

T-cell lymphoma with a granulomatous lesion of the lungs after autologous hematopoietic stem cell transplantation for Epstein–Barr virus-positive diffuse large B-cell lymphoma: a unique rare case of metachronous B-cell and T-cell lymphoma

Epstein–Barr virus (EBV) is associated with the pathogenesis of a variety of malignancies, most notably lymphomas. Especially in the background of immunodeficiency, such as primary immunodeficiency disorder (P...

Authors: Yusuke Kajimoto, Yasuhiro Terasaki, Mika Terasaki, Shinobu Kunugi, Yugo Okabe, Satoshi Wakita, Koiti Inokuchi and Akira Shimizu

Plasmacytoid urothelial carcinoma of renal pelvis with positive zinc finger E–box–binding homeobox 1: a case report

The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case of a plasmacytoid urothelial carcinoma of the renal pelvis in which the expression of zinc fi...

Authors: Atsuko Takada-Owada, Yumi Nozawa, Masato Onozaki, Shuhei Noda, Tsengelmaa Jamiyan, Yuumi Tokura, Yoshimasa Nakazato, Takao Kamai and Kazuyuki Ishida

Unilateral synchronous papillary renal neoplasm with reverse polarity and clear cell renal cell carcinoma: a case report with KRAS and PIK3CA mutations

The presence of histologically different neoplasms in the same organ is rare in pathologic practice. We report the first case of synchronous clear cell renal cell carcinoma (clear cell RCC) and papillary renal...

Authors: Hyun Jung Lee, Dong Hoon Shin, Joon Young Park, So Young Kim, Chung Su Hwang, Jung Hee Lee, Jee Yeon Kim, Mee Young Sol and Jong Kil Nam

Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reports

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of extranodal non-Hodgkin lymphomas for which diagnosis can be challenging given the potential for overlap with inflammatory dermatoses. Current diag...

Authors: Rebecca Rojansky, Sebastian Fernandez-Pol, Erica Wang, Kerri E. Rieger, Roberto A. Novoa, James L. Zehnder, Christian A. Kunder, Youn H. Kim, Michael S. Khodadoust and Ryanne A. Brown

Cytokeratin-positive interstitial reticulum cell (CIRC) tumor in the lymph node: a case report of the transformation from the epithelioid cell type to the spindle cell type

Cytokeratin-positive interstitial reticulum cells (CIRCs), which are a subgroup of fibroblastic reticular cells (FRCs), are known to be present in the lymph nodes. There have been only a few cases of tumors de...

Authors: Sachiko Kaji, Nobuyuki Hiruta, Daisuke Sasai, Makoto Nagashima, Rintaro Ohe and Mitsunori Yamakawa

Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases

Hepatic epithelioid hemangioendothelioma is an extremely rare malignant vascular tumor which is often multifocal and, in many cases, discovered incidentally. Here, we describe the clinicopathological features ...

Authors: Nasir Ud Din, Shabina Rahim, Tamana Asghari, Jamshid Abdul-Ghafar and Zubair Ahmad

Immunohistochemical markers and the clinical course of adenosarcoma: a series of seven cases

Uterine adenosarcoma, a rare uterine tumor subtype, is a biphasic tumor consisting of epithelial and mesenchymal elements. To date, there is no research comparing the histopathological features and immunohisto...

Authors: Makiko Omi, Akiko Tonooka, Tomohiro Chiba, Yuji Tanaka, Atsushi Fusegi, Yoichi Aoki, Hidetaka Nomura, Hiroyuki Kanao and Yutaka Takazawa

Early-stage multi-differentiated gastric carcinosarcoma and post-resection local recurrence: a case report

Carcinosarcoma is a rare neoplasm with a poor prognosis that is most often discovered at an advanced stage; a gastric carcinosarcoma is even rarer than carcinosarcomas originating in other organs, such as the ...

Authors: Akihiro Shioya, Nozomu Kurose, Kenichi Mizutani, Motona Kumagai, Ken Kawaura, Naohiko Nakamura, Takeo Kosaka, Nozomu Motono, Hidetaka Uramoto and Sohsuke Yamada

Fibrin-associated diffuse large B-cell lymphoma with plasmacytic differentiation: case report and literature review

Primary cardiac lymphomas are extremely rare entities (< 2% of cardiac tumours) and the most frequent histologic type is diffuse large B-cell lymphoma (DLBCL). Fibrin-associated DLBCL (FA-DLBCL) is a very unus...

Authors: Esther Moreno Moreno, Ana Ferrer-Gómez, Héctor Pian Arias, Irene García García and Mónica García-Cosío

Publisher Correction to: Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images

An amendment to this paper has been published and can be accessed via the original article.

Authors: Danielle J. Fassler, Shahira Abousamra, Rajarsi Gupta, Chao Chen, Maozheng Zhao, David Paredes, Syeda Areeha Batool, Beatrice S. Knudsen, Luisa Escobar-Hoyos, Kenneth R. Shroyer, Dimitris Samaras, Tahsin Kurc and Joel Saltz

Lymphoepithelioma-like carcinoma in liver not associated with Epstein-Barr virus: a report of 3 cases and literature review

Lymphoepithelioma-like carcinoma is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration. It can be divided in...

Authors: Kai Zhang, Changcheng Tao, Zonggui Tao, Fan Wu, Songlin An, Jianxiong Wu and Weiqi Rong

Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors

While ETV6- NTRK3 fusion is common in infantile fibrosarcoma, NTRK1/3 fusion in pediatric tumors is scarce and, consequently, not well known. Herein, we evaluated for the presence of NTRK1/3 fusion in pediatric m...

Authors: Jeongwan Kang, Jin Woo Park, Jae-Kyung Won, Jeong Mo Bae, Jaemoon Koh, Jeemin Yim, Hongseok Yun, Seung-Ki Kim, Jung Yoon Choi, Hyoung Jin Kang, Woo Sun Kim, Joo Heon Shin and Sung-Hye Park

Phaeoacremonium species detected in fine needle aspiration: a rare case report

Fine needle aspiration cytology (FNAC) with rapid on-site evaluation has a great potential for the diagnosis of fungal lesions and other opportunistic infections. Fungal infections have been in increasing tren...

Authors: Santosh Tummidi, Bitan Naik, Arundhathi Shankaralingappa, Pavithra Balakrishna, Arati Ankushrao Bhadada and Navya Kosaraju

Clinician-ordered peripheral blood smears have low reimbursement and variable clinical value: a three-institution study, with suggestions for operational efficiency

Peripheral blood smears are performed to evaluate a variety of hematologic and non-hematologic disorders. At the authors’ institutions, clinician requests for pathologist-performed blood smear reviews have inc...

Authors: Amy K. Beckman, Valerie L. Ng, David L. Jaye, Manila Gaddh, Sarah A. Williams, Sophia L. Yohe, Lin Zhang and Michael A. Linden

Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma

Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. Despite its characteristic hist...

Authors: Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Yosuke Toya, Risaburo Akasaka, Takayuki Matsumoto and Tamotsu Sugai

Recurrent uterine tumors resembling ovarian sex-cord tumors with the growth regulation by estrogen in breast cancer 1-nuclear receptor coactivator 2 fusion gene: a case report and literature review

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare mesenchymal neoplasms predominantly arising in perimenopausal and postmenopausal women. UTROSCTs with growth regulation by estrogen in brea...

Authors: Bin Chang, Qianming Bai, Lin Liang, Huijuan Ge and Qianlan Yao

Spotlight on Ki67 as a prognostic marker in early breast cancer: all that glitters may not be gold

Kang and colleagues evaluated on a case series of 1848 breast cancer (BC) patients operated for a first primary ER positive HER2 negative BC if Ki67 expression is a significant prognostic factor only when PgR ...

Authors: Roberta Maltoni, Michela Palleschi, Sara Ravaioli, Maria Maddalena Tumedei, Mattia Altini and Sara Bravaccini

Clinicopathological heterogeneity between primary and metastatic sites of gastroenteropancreatic neuroendocrine neoplasm

Chromogranin A (CgA), synaptophysin (Syn) and the Ki-67 index play significant roles in diagnosis or the evaluation of the proliferative activity of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). ...

Authors: Huiying Shi, Chen Jiang, Qin Zhang, Cuihua Qi, Hailing Yao and Rong Lin

Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods.

Authors: Shintaro Sukegawa, Sawako Ono, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka and Yoshihiko Furuki

Metastatic colon cancer of the small intestine diagnosed using genetic analysis: a case report

Intestinal-type adenocarcinoma is widely detected in the gastrointestinal tract, head and neck, lower respiratory and urinary systems. Determining the nature (monoclonal or multicentric) of the intestinal aden...

Authors: Mikiko Matsuo, Yuichiro Hatano, Yuko Imaizumi, Takahiro Kuroda, Toshinori Arai, Hiroyuki Tomita, Nobuhisa Matsuhashi, Kazuhiro Yoshida and Akira Hara

Pulmonary epithelial–myoepithelial carcinoma without AKT1, HRAS or PIK3CA mutations: a case report

Pulmonary epithelial–myoepithelial carcinoma is a rare subtype of lung cancer. Because of its rarity, the molecular information on this carcinoma is insufficient.

Authors: Naoki Yanagawa, Ayaka Sato, Masao Nishiya, Masamichi Suzuki, Ryo Sugimoto, Mitsumasa Osakabe, Noriyuki Uesugi, Hajime Saito and Tamotsu Sugai

A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix

Squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancer. Compared to squamous cell carcinomas, adenocarcinomas are more common in younger women and have a poorer prognosis. Ye...

Authors: Hailing Li, Xiaotong Jing, Jie Yu, Jiannan Liu, Tingguo Zhang, Shiming Chen and Xiaofang Zhang

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19) – anatomic pathology perspective on current knowledge

The world is currently witnessing a major devastating pandemic of Coronavirus disease-2019 (COVID-19). This disease is caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-...

Authors: Sambit K. Mohanty, Abhishek Satapathy, Machita M. Naidu, Sanjay Mukhopadhyay, Shivani Sharma, Lisa M. Barton, Edana Stroberg, Eric J. Duval, Dinesh Pradhan, Alexandar Tzankov and Anil V. Parwani

A Japanese patient with ductal carcinoma of the prostate carrying an adenomatosis polyposis coli gene mutation: a case report

Ductal carcinoma of the prostate is a histological subtype with a higher mortality than acinar adenocarcinoma. The number of cases is small and there are no treatment guidelines. We believe that this is the fi...

Authors: Kota Umeda, Takeo Kosaka, Kohei Nakamura, Toshikazu Takeda, Shuji Mikami, Hiroshi Nishihara and Mototsugu Oya

Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

MicroRNAs (miRNAs) serve as novel promising biomarkers for the diagnosis and prognosis of many human diseases. This study investigated the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosi...

Authors: Weibo Lv, Tao Zhang, Hongwei Zhao, Shuang He, Bingwei Li, Yang Gao and Wenying Pan

Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images

Multiplex immunohistochemistry (mIHC) permits the labeling of six or more distinct cell types within a single histologic tissue section. The classification of each cell type requires detection of uniquely colo...

Authors: Danielle J. Fassler, Shahira Abousamra, Rajarsi Gupta, Chao Chen, Maozheng Zhao, David Paredes, Syeda Areeha Batool, Beatrice S. Knudsen, Luisa Escobar-Hoyos, Kenneth R. Shroyer, Dimitris Samaras, Tahsin Kurc and Joel Saltz

The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

Molecular diagnostics can be decisive in the differential diagnosis between a somatic metastasis of type II testicular germ cell tumor (TGCT) or a second primary carcinoma. This is in line with recent recommen...

Authors: Mariëtte E. G. Kranendonk, Wenzel M. Hackeng, G. Johan A. Offerhaus, Folkert H. M. Morsink, Geertruida N. Jonges, Gerard Groenewegen, Pieter-Jaap Krijtenburg, Heinz-Josef Klümpen, Wendy W. J. de Leng, Leendert H. J. Looijenga and Lodewijk A. A. Brosens

Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway

Fibro-adipose vascular anomaly (FAVA) is a new entity of vascular anomalies with somatic and mosaic gain-of-function mutations of the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3C...

Authors: Yumiko Hori, Katsutoshi Hirose, Noriko Aramaki-Hattori, Sachi Suzuki, Robert Nakayama, Masanori Inoue, Takahiro Matsui, Masaharu Kohara, Satoru Toyosawa and Eiichi Morii

Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases

Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of...

Authors: Michael Lee, Huaibin Mabel Ko, Anthony Rubino, Hwajeong Lee, Ryan Gill and Stephen M. Lagana

miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2

Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the ex...

Authors: Chunlei Liu and Xiuling Yi

Desmoplastic small round cell tumor of the kidney: a case report

Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm seen in children and young adults, usually manifested by involvement of abdominal serosa. Here, we present an unusual case of primary ...

Authors: Dilek Ertoy Baydar, Ayse Armutlu, Oguz Aydin, Ayhan Dagdemir and Yarkin Kamil Yakupoglu

SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

Bladder cancer (BC) is a common and deadly disease. Over the past decade, a number of genetic alterations have been reported in BC. Bladder urothelium expresses abundant urea transporter UT-B encoded by Slc14a1 g...

Authors: Zhongying Guo, Xiaobing Niu, Guangbo Fu, Baoxue Yang, Guangping Chen and Su’an Sun

46, XY disorder of sex development (DSD) complicated by a serous borderline tumor of the ovary: a case report and review of the literature

Patients with 46, XY disorder of sex development (DSD) are predisposed to the development of gonadal tumors, particularly germ cell tumors and gonadoblastoma. However, to the best of our knowledge, there are n...

Authors: Jiangying Zhao, Jiao Peng, Sisi He, Jia Yang and Xiaojun Pang

Peritumoral/vascular expression of PSMA as a diagnostic marker in hepatic lesions

The differential diagnosis between primary cholangiocarcinoma and metastatic pancreatobiliary adenocarcinoma is histologically challenging due to lack of distinct morphological features and reliable molecular ...

Authors: Wei Chen, Zhenghong Lee, Amad Awadallah, Lan Zhou and Wei Xin

Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis

Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common ...

Authors: Pavel Dundr, Mária Gregová, Kristýna Němejcová, Michaela Bártů, Nikola Hájková, Jan Hojný, Ivana Stružinská and Daniela Fischerová

Serious takotsubo cardiomyopathy: an autopsy case presenting severe irreversible myocardial damage after frequent episodes of recurrence

Takotsubo cardiomyopathy is characterized by transient dysfunction of the medial to apical segment of the left ventricle. Recurrence within a few months or years has been reported and serious complications, in...

Authors: Kenichi Mizutani, Akihiro Shioya, Yasuyo Hirose, Ryuhei Saito and Sohsuke Yamada

Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor. In addition to the main ATC type with classical histopathological features, the other morphological types of ATC include paucicellular variant, ang...

Authors: Jixuan Liu, Ni Cui, Wenjia Ding, Xinjie Dong, Xiaoshuai Chen, Jun Jiang and Yafang Liu

Unexpected endometrial malacoplakia related to abortion and placental rests retention: a case report

Malacoplakia is a rare chronic inflammatory disease. The name derives from the Greek “μαλακός” meaning “soft” and “πλάξ” meaning “plaque”, describing its usual macroscopic presentation as a friable yellow soft pl...

Authors: Antonio d’Amati, Emilio Bellitti and Leonardo Resta

Semantic segmentation to identify bladder layers from H&E Images

Identification of bladder layers is a necessary prerequisite to bladder cancer diagnosis and prognosis. We present a method of multi-class image segmentation, which recognizes urothelium, lamina propria, muscu...

Authors: Muhammad Khalid Khan Niazi, Enes Yazgan, Thomas E. Tavolara, Wencheng Li, Cheryl T. Lee, Anil Parwani and Metin N. Gurcan

Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America

Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be cha...

Authors: Peter F. Rambau, Martin Köbel, Derek Tilley, Alex Mremi, Robert Lukande and William Muller

The spectrum of pathological findings in coronavirus disease (COVID-19) and the pathogenesis of SARS-CoV-2

Authors: Rolf F. Barth, L. Maximillian Buja and Anil V. Parwani

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with in...

Authors: Esther Moreno, Juan M. Rosa-Rosa, Tamara Caniego-Casas, Ignacio Ruz-Caracuel, Cristian Perna, Carmen Guillén and José Palacios