Articles

Perianal Paget’s disease: a clinicopathological and immunohistochemical study of 13 cases

Perianal Paget’s disease (PPD) is rare and mostly described in clinical literature as case reports or small series.

Authors: Xiaoyan Liao, Xiuli Liu, Xuemo Fan, Jinping Lai and Dongwei Zhang

Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC

To investigate the expression and function of RSK4, MMP-9 and CD44 in primary clear cell renal cell carcinoma (primary ccRCC) and metastatic clear cell renal cell carcinoma (metastatic ccRCC), as well as the c...

Authors: Jing Ma, Mingyang Li, Jia Chai, Kaijing Wang, Peifeng Li, Yixiong Liu, Danhui Zhao, Junpeng Xu, Kangjie Yu, Qingguo Yan, Shuangping Guo, Zhe Wang and Linni Fan

HER2 expression and relevant clinicopathological features in esophageal squamous cell carcinoma in a Chinese population

Despite great progress in surgery and other treatments, the prognosis of patients with esophageal squamous cell carcinoma (ESCC) is still very poor. HER2 has strong therapeutic implications in certain cancers,...

Authors: Lulu Rong, Bingzhi Wang, Lei Guo, Xiuyun Liu, Bingning Wang, Jianming Ying, Liyan Xue and Ning Lu

IGF2BP3 (IMP3) expression in angiosarcoma, epithelioid hemangioendothelioma, and benign vascular lesions

Insulin-like growth factor-2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) is an oncofetal protein that is expressed in various cancer types, and its expression is often associated with poor prognosis. IGF...

Authors: Misuzu Okabayshi, Tatsuki R. Kataoka, Marina Oji, Satoko Mibayashi, Kentaro Odani, Atsushi Otsuka and Hironori Haga

Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer

Gastric cancer is one of the most common cancers leading to high cancer mortality. MicroRNA-484 (miR-484) has been evaluated as a biomarker for various types of cancers. The subject of this study is to investi...

Authors: Ying Li, Yusong Liu, Jie Yao, Rui Li and Xiaocheng Fan

Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV

Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva.

Authors: Xavier Catteau, Nicky D’haene and Jean-Christophe Noël

Primary small intestine mesenteric low-grade fibromyxoid sarcoma with foci of atypical epithelioid whorls and diffuse DOG1 expression: a case report

Low-grade fibromyxoid sarcoma (LGFMS) is a rare fibroblastic tumor often involving deep tissue of trunk and lower extremities in young to middle-aged patients. Rarely, LGFMS can occur in other sites including ...

Authors: Jialing Huang, Steven Cohen and Gerorge Jour

Extraovarian Brenner tumor in the uterus: a case report and review of literature

Extraovarian Brenner tumors (EOBTs) are extremely rare and can be observed incidentally in both female and male patients, raising concerns regarding the origin of Brenner tumors.

Authors: Rui-Yue Hu, Yan-Juan Deng, Hao-Hao Zhu, Jing Zhou, Ming Hu, Xiao-Qing Liang, Qiu-Jin Xiao, Lv Zhou, Xiao-Yu Peng, Xing-Wei Zhang, Ning Ji and Huan Deng

Clinicopathologic analysis of renal cell carcinoma containing Intratumoral fat with and without osseous metaplasia

There is minimal information regarding the prevalence of intratumoral adipose in renal cell carcinoma (RCC), and no study has assessed the impact of intratumoral adipose on the preoperative imaging diagnosis. ...

Authors: Zhaoying Xian, Jason O. Orien, Geoffrey N. Box and Debra L. Zynger

Fibromatosis-like metaplastic carcinoma: a case report and review of the literature

We report an unusual case of low-grade fibromatosis-like metaplastic carcinoma (LG-FLMC) of the breast. This exceedingly rare epithelial breast malignancy has been reported only 68 times in the past 20 years, ...

Authors: Jasper Victoor, Claire Bourgain, Sara Vander Borght, Isabelle Vanden Bempt, Carine De Rop and Giuseppe Floris

Silence of miR-32-5p promotes endothelial cell viability by targeting KLF2 and serves as a diagnostic biomarker of acute myocardial infarction

MicroRNAs (miRNAs) have been investigated in various cardiovascular diseases. As a fatal disease, acute myocardial infarction (AMI) is a serious global health burden. The purpose of this study was to investiga...

Authors: Yunxiang Dai, Tingguo Yan and Yuming Gao

Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic

Insulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to b...

Authors: Fangxiao Cheng, Geheng Yuan, Jiao He, Yimin Shao, Junqing Zhang and Xiaohui Guo

Factors affecting cytological results of endoscopic ultrasound guided-fine needle aspiration during learning

Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a standard procedure used to obtain tissue samples for diagnosis of solid retroperitoneal tumours. However, this procedure demands high technica...

Authors: Jian-Han Lai, Hsiang-Hung Lin and Ching-Chung Lin

Markers of immune activation: novel biomarkers to predict the early-warning indicator of patients with papillary thyroid carcinoma

Papillary thyroid carcinoma (PTC) is an indolent tumor that is exploding with increasing thyroid nodules (TN). Environmental carcinogens, lifestyle changes increased the incidence of thyroid carcinoma. With th...

Authors: Hongsheng Lu, Lihong Zhang, Yuechu Dai, Yanyun Ruan, Xuequan Cao, Xiaobo Cai, Sihan Ruan and Qi Chen

Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a case report and review of the literature

Primary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma that is characterized in most cases by recurrent balanced chromosomal translocation t(2;22)(q33;q12) leading to the oncogenic fusion gene

Authors: Zhenwei Chen, Yihui Yang, Rongming Chen, Chi Sing Ng and Hongqi Shi

FOXM 1 induces Vasculogenic mimicry in esophageal cancer through β-catenin /Tcf4 signaling

To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry).

Authors: Lili Cheng, Qi Wang, Xiaoying Tao, Yanzi Qin, Qiong Wu, Dafang Zheng, Damin Chai, Yong Zhang, Dongbing Lu, Hongfei Ci, Zhiwei Wang, Jia Ma, Danna Wang, Zenong Cheng, Shiwu Wu and Yisheng Tao

Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis

Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease.

Authors: Toshitetsu Hayashi, Mitsuyoshi Hirokawa, Seiji Kuma, Miyoko Higuchi, Ayana Suzuki, Risa Kanematsu, Takumi Kudo, Naomi Katsuki, Reiji Haba and Akira Miyauchi

Squamous cell carcinoma with sarcomatoid differentiation or carcinosarcoma of the uterine cervix associated with HPV33 infection: report of a rare case

Squamous cell carcinoma is the most common malignant tumor of the uterine cervix with a well-documented link to infection with human papillomaviruses (HPV). According to a recent classification, there are seve...

Authors: Jan Hrudka, Blanka Rosová and Michael J. Halaška

An NRAS mutation in primary malignant melanoma of the lung: a case report

Primary malignant melanoma of the lung (PML) is extremely rare. No precursor lesions of PML have been identified, and little is known about the genetic mutations associated with the disease. Typically, 15–20% ...

Authors: Takashi Hibiya, Meiro Tanaka, Mai Matsumura, Ayako Aoki, Tadashi Ikegami, Koji Okudela, Naomi Kawano and Kenichi Ohashi

The role of CD68+ macrophage in classical Hodgkin lymphoma patients from Egypt

CD68+ tumor-associated macrophages (TAM) play an important role in the progression of classical Hodgkin lymphoma (cHL). We assessed the role of CD20 and CD68 + TAM in a cohort of cHL patients from Egypt and corre...

Authors: Osama Mohamed, Ahmed El Bastawisy, Nasr Allahlobi, Mona S. Abdellateif, Abdel Rahman N. Zekri, Sabry Shaarawy, Zeinab Korany, Marwa Mohanad and Abeer A. Bahnassy

Comparison of the SuperARMS and ARMS for detecting EGFR mutations in liquid-based cytology specimens from NSCLC patients

Non-surgical cytological specimens are adequate not only for accurate histological subtyping but also for molecular profiling. A modified amplification refractory mutation system polymerase chain reaction (ARM...

Authors: Wei Wu, Ziyang Cao, Wei Zhang, Liping Zhang, Likun Hou and Chunyan Wu

ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report

Gastrointestinal stromal tumors (GISTs) are the most common type of adult mesenchymal neoplasms. The events that drive GIST oncogenesis are primarily KIT or PDGFRA mutations, which lead to the susceptibility of t...

Authors: Jun Fan, Ming Yang, Bo Huang, Zhenkao Wang, Danju Luo, Jiwei Zhang, Peng Zhang, Heshui Shi, Yan Li and Xiu Nie

Cutaneous pilomatrical carcinosarcoma: a case report with molecular analysis and literature review

Cutaneous pilomatrical carcinosarcoma (CS) is a very rare biphasic tumor composed of admixed epithelial and mesenchymal malignant cells, with limited information on its pathogenesis. We report a case of piloma...

Authors: Thi My Hanh Luong, Yuko Akazawa, Zhanna Mussazhanova, Katsuya Matsuda, Nozomi Ueki, Shiro Miura, Toshihide Hara, Hiroko Yokoyama and Masahiro Nakashima

Targeted literature review on use of tumor mutational burden status and programmed cell death ligand 1 expression to predict outcomes of checkpoint inhibitor treatment

To achieve optimal outcomes, an individual approach is needed in the treatment and care of patients. The potential value of tumor mutational burden (TMB) status and/or programmed cell death ligand 1 (PD-L1) ex...

Authors: Tina Krieger, Isobel Pearson, Judith Bell, Jim Doherty and Paul Robbins

Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report

Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment.

Authors: Hiroshi Hongo, Takeo Kosaka, Eriko Aimono, Hiroshi Nishihara and Mototsugu Oya

Uterine intravenous leiomyomatosis with an isolated large metastasis to the right atrium: a case report

An intravenous leiomyomatosis is a special type of uterine leiomyoma characterized by the formation of benign leiomyomatous tissue within the vascular wall. Although histologically benign, intracardiac metasta...

Authors: Mitsutake Yano, Tomomi Katoh, Yoshie Nakajima, Shiro Iwanaga, Rei Kin, Eito Kozawa and Masanori Yasuda

Myoepithelioma-like tumor of the vulvar region: a case report in China and review of the literature

Myoepithelioma-like tumor of the vulvar region (MELTVR) is a recently described mesenchymal neoplasm which typically arising in vulvar regions of adult women.

Authors: Yan Xu, Hui Gao and Jin-Li Gao

Orbital involvement by NUT midline carcinoma: new presentation and encouraging outcome managed by radiotherapy combined with tyrosine kinase inhibitor: a case report

NUT midline carcinoma (NMC) is a poorly differentiated squamous cancer with a median survival at less than 7 months. NMC is resistant to conventional chemotherapies and characterized by rearrangement of the NUT g...

Authors: Peiwei Chai, Chuandi Zhou, Renbing Jia and Yefei Wang

Causes of misdiagnoses by thyroid fine-needle aspiration cytology (FNAC): our experience and a systematic review

FNA is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules. The aims of this study were to determine the diagnostic utility of FNAC performed ...

Authors: Yanli Zhu, Yuntao Song, Guohui Xu, Zhihui Fan and Wenhao Ren

Next generation diagnostic pathology: use of digital pathology and artificial intelligence tools to augment a pathological diagnosis

Authors: Anil V. Parwani

Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature

Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach...

Authors: Yangkun Wang, Pei Guo, Zhishang Zhang, Runde Jiang and Zuguo Li

MicroRNA-937 is overexpressed and predicts poor prognosis in patients with colon cancer

Colon cancer is a heterogeneous tumor and a leading cause of cancer-related mortality. MicroRNA (miRNA) has been proposed as the biomarker in cancers. The aim of this study was to investigate the clinical sign...

Authors: Huiya Liu, Lin Ma, Ling Wang and Yizuo Yang

Splenic cord capillary hemangioma with non-islet cell tumor hypoglycemia: a case report

Splenic cord capillary hemangioma is a rare benign vascular lesion classified as a splenic hamartoma. On the other hand, non-islet cell tumor hypoglycemia (NICTH) is one of the rare causes of spontaneous hypog...

Authors: Tatsuaki Daimon, Takeo Kosaka, Minoru Horinaga, Junichi Saito, Yoshito Ueyama, Shoji Matsuzaki and Mototsugu Oya

Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma

Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the f...

Authors: Caroline E. Nunes-Xavier, Olaia Aurtenetxe, Laura Zaldumbide, Ricardo López-Almaraz, Asier Erramuzpe, Jesús M. Cortés, José I. López and Rafael Pulido

Comparative pathologic analysis of mediastinal B-cell lymphomas: selective expression of p63 but no GATA3 optimally differentiates primary mediastinal large B-cell lymphoma from classic Hodgkin lymphoma

Interpretation of mediastinal biopsy is often challenging even for experienced pathologists especially when a hematolymphoid neoplasm is suspected. Primary mediastinal large B-cell lymphoma (PMLBCL) and classi...

Authors: Hyun-Jung Kim, Hee Kyung Kim, Gyeongsin Park, Soo Kee Min, Hee Jeong Cha, Hyekyung Lee, Suk Jin Choi, Hee Young Na, Ji-Young Choe and Ji Eun Kim

MicroRNA-1298 is downregulated in non-small cell lung cancer and suppresses tumor progression in tumor cells

MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lu...

Authors: Zhonghai Du, Jun Wu, Juan Wang, Yan Liang, Sensen Zhang, Zhimei Shang and Wenchao Zuo

Concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in patients with diffuse interstitial lung disease

Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for the diagnosis of interstitial lung disease (ILD). However, only one study has compared TBLC and surgical lung biopsy (SLB)...

Authors: Yoshiaki Zaizen, Yasuo Kohashi, Kishio Kuroda, Kazuhiro Tabata, Yuka Kitamura, Akira Hebisawa, Yuji Saito and Junya Fukuoka

Chest wall lymph node metastasis from follicular thyroid carcinoma: a rare case report

Distant metastases from follicular thyroid carcinoma are mainly hematogenous and are commonly observed in the lungs and bones. Other rare sites are the parotid gland, skin, brain, ovary, adrenal gland, kidney,...

Authors: Taolang Li, Zhiyuan Ma, Chengli Lu, Quanzhong Zhou, Zelong Feng, Xinglong Wu, Yi Luo, Dan Li, Xiaoming Cheng and Xuemei Liu

Uterine lesions with sex cord-like architectures: a systematic review

Sex cord-like elements are rarely observed in uterine lesions, but these morphological patterns could appear in a variety of uterine tumors and non-tumorous lesions. In this review, we collected the literature...

Authors: Meng Jia, Ping-Li Sun and Hongwen Gao

Expression of P63 and its correlation with prognosis in diffuse large B-cell lymphoma: a single center experience

Large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma among adults. In some cases, DLBCL may seem similar to carcinoma cells, presenting a round, oval, or polygonal shape and clear nu...

Authors: Wan-Ming Hu, Jie-Tian Jin, Chen-Yan Wu, Jia-Bin Lu, Li-Hong Zhang, Jing Zeng and Su-Xia Lin

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics

Follicular thyroid carcinoma (FTC) is a neoplasm that presents with a micro-follicular growth pattern and a neutrally stained cytoplasm. Seldom, FTCs display unusual morphological characteristics – but given t...

Authors: Martin Hysek, Kenbugul Jatta, Adam Stenman, Eva Darai-Ramqvist, Jan Zedenius, Anders Höög and C. Christofer Juhlin

Vulvar myeloid sarcoma as the presenting symptom of acute myeloid leukemia: a case report and literature review of Chinese patients, 1999–2018

Myeloid sarcoma (MS), which represents a rare malignancy that comprises of myeloid blasts occurring at extra-medullary sites, closely correlates with the onset and relapse of acute myeloid leukemia (AML) and o...

Authors: Xilin Zhang, Peichen Huang, Zhuo Chen, Xinling Bi, Ying Wang and Jianhua Wu

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation

Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction b...

Authors: Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho and Filomena M. Carvalho

The role of p-Stat3 Y705 immunohistochemistry in glioblastoma prognosis

In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Sign...

Authors: Sergiu Susman, Radu Pîrlog, Daniel Leucuța, Andrei Otto Mitre, Vlad Adrian Padurean, Carmen Melincovici, Ioana Moldovan, Doinița Crișan and Stefan Ioan Florian

Clinical, genetic, and molecular characterization of hyperphosphatasia with mental retardation: a case report and literature review

Hyperphosphatasia with mental retardation syndrome (HPMRS) is a recessive disorder characterized by high blood levels of alkaline phosphatase together with typical dysmorphic signs such as cleft palate, intell...

Authors: Layal Abi Farraj, Wassim Daoud Khatoun, Naji Abou Chebel, Victor Wakim, Katia Dawali and Michella Ghassibe-Sabbagh

A unique uterine cervical “teratocarcinosarcoma”: a case report

Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closel...

Authors: Kozue Ito, Mitsutake Yano, Aiko Ogasawara, Maiko Miwa, Eito Kozawa and Masanori Yasuda

MicroRNA 3113-5p is a novel marker for early cardiac ischemia/reperfusion injury

Ischemia/reperfusion (I/R) injury of heart is one of the major causes of acute cardiac injury, which may result in worsening or even loss of heart function. With novel microRNAs being evolutionarily discovered...

Authors: Yuanyuan Chen, Xing Ye and Fengping Yan

PRMT1 expression in renal cell tumors- application in differential diagnosis and prognostic relevance

Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal c...

Authors: Jelena Filipović, Martina Bosić, Sanja Ćirović, Maja Životić, Duško Dunđerović, Dejan Đorđević, Snežana Živković-Perišić, Aleksandar Lipkovski and Jasmina Marković-Lipkovski

miR-132 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability

Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...

Authors: Xuegui Zhou, Cuiping Xiang and Xiaoxia Zheng

MicroRNA-99b predicts clinical outcome of osteosarcoma and suppresses tumor cell proliferation, migration and invasion

Osteosarcoma (OS) is a malignancy predominantly occurred in children and adolescents. Numerous microRNAs are involved in the pathogenesis of various cancers. This study aimed to investigate the expression prof...

Authors: Xin Shi and Xingfa Guan