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  1. MicroRNAs (miRNAs) have been reported to serve pivotal roles in tumorigenesis. This study sough to assess the expression and clinical significance of microRNA-1298 (miR-1298) in patients with non-small cell lu...

    Authors: Zhonghai Du, Jun Wu, Juan Wang, Yan Liang, Sensen Zhang, Zhimei Shang and Wenchao Zuo

    Citation: Diagnostic Pathology 2019 14:132

    Content type: Research

    Published on:

  2. Increasing evidence indicates the utility of transbronchial lung cryobiopsy (TBLC) for the diagnosis of interstitial lung disease (ILD). However, only one study has compared TBLC and surgical lung biopsy (SLB)...

    Authors: Yoshiaki Zaizen, Yasuo Kohashi, Kishio Kuroda, Kazuhiro Tabata, Yuka Kitamura, Akira Hebisawa, Yuji Saito and Junya Fukuoka

    Citation: Diagnostic Pathology 2019 14:131

    Content type: Research

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  3. Distant metastases from follicular thyroid carcinoma are mainly hematogenous and are commonly observed in the lungs and bones. Other rare sites are the parotid gland, skin, brain, ovary, adrenal gland, kidney,...

    Authors: Taolang Li, Zhiyuan Ma, Chengli Lu, Quanzhong Zhou, Zelong Feng, Xinglong Wu, Yi Luo, Dan Li, Xiaoming Cheng and Xuemei Liu

    Citation: Diagnostic Pathology 2019 14:130

    Content type: Case Report

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  4. Large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma among adults. In some cases, DLBCL may seem similar to carcinoma cells, presenting a round, oval, or polygonal shape and clear nu...

    Authors: Wan-Ming Hu, Jie-Tian Jin, Chen-Yan Wu, Jia-Bin Lu, Li-Hong Zhang, Jing Zeng and Su-Xia Lin

    Citation: Diagnostic Pathology 2019 14:128

    Content type: Research

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  5. Follicular thyroid carcinoma (FTC) is a neoplasm that presents with a micro-follicular growth pattern and a neutrally stained cytoplasm. Seldom, FTCs display unusual morphological characteristics – but given t...

    Authors: Martin Hysek, Kenbugul Jatta, Adam Stenman, Eva Darai-Ramqvist, Jan Zedenius, Anders Höög and C. Christofer Juhlin

    Citation: Diagnostic Pathology 2019 14:127

    Content type: Case Report

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  6. Myeloid sarcoma (MS), which represents a rare malignancy that comprises of myeloid blasts occurring at extra-medullary sites, closely correlates with the onset and relapse of acute myeloid leukemia (AML) and o...

    Authors: Xilin Zhang, Peichen Huang, Zhuo Chen, Xinling Bi, Ying Wang and Jianhua Wu

    Citation: Diagnostic Pathology 2019 14:126

    Content type: Case Report

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  7. Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction b...

    Authors: Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho and Filomena M. Carvalho

    Citation: Diagnostic Pathology 2019 14:125

    Content type: Case Report

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  8. In spite of the multimodal treatment used today, glioblastoma is still the most aggressive and lethal cerebral tumour. To increase survival in these patients, novel therapeutic targets must be discovered. Sign...

    Authors: Sergiu Susman, Radu Pîrlog, Daniel Leucuța, Andrei Otto Mitre, Vlad Adrian Padurean, Carmen Melincovici, Ioana Moldovan, Doinița Crișan and Stefan Ioan Florian

    Citation: Diagnostic Pathology 2019 14:124

    Content type: Research

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  9. Hyperphosphatasia with mental retardation syndrome (HPMRS) is a recessive disorder characterized by high blood levels of alkaline phosphatase together with typical dysmorphic signs such as cleft palate, intell...

    Authors: Layal Abi Farraj, Wassim Daoud Khatoun, Naji Abou Chebel, Victor Wakim, Katia Dawali and Michella Ghassibe-Sabbagh

    Citation: Diagnostic Pathology 2019 14:123

    Content type: Case Report

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  10. Teratocarcinosarcoma (TCS) is a rare aggressive tumor of the nasal cavity and paranasal sinuses and has both epithelial and two or more mesenchymal components. In other organs, 5 cases of ovarian tumors closel...

    Authors: Kozue Ito, Mitsutake Yano, Aiko Ogasawara, Maiko Miwa, Eito Kozawa and Masanori Yasuda

    Citation: Diagnostic Pathology 2019 14:122

    Content type: Case Report

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  11. Protein arginine methyltransferase-1 (PRMT1) is associated with the progression of various tumor types and the process of epithelial to mesenchymal transition (EMT). However, the expression of PRMT1 in renal c...

    Authors: Jelena Filipović, Martina Bosić, Sanja Ćirović, Maja Životić, Duško Dunđerović, Dejan Đorđević, Snežana Živković-Perišić, Aleksandar Lipkovski and Jasmina Marković-Lipkovski

    Citation: Diagnostic Pathology 2019 14:120

    Content type: Research

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  12. Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes. Strategies that improve trophoblast cell function are important methods for GDM treatment. This study aimed to investigate the expression a...

    Authors: Xuegui Zhou, Cuiping Xiang and Xiaoxia Zheng

    Citation: Diagnostic Pathology 2019 14:119

    Content type: Research

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  13. Carboxypeptidase X, M14 family member 2 (CPXM2), has been associated with several human developmental disorders. However, whether CPXM2 is involved in oncogenesis or tumor progression remains unclear. Currentl...

    Authors: Xin Zhao, Ronghang Li, Qian Wang, Minfei Wu and Yanbing Wang

    Citation: Diagnostic Pathology 2019 14:118

    Content type: Research

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  14. Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an...

    Authors: Yuxin Li, Yongliang Teng, Xiaofei Wei, Zhuang Tian, Yuqing Cao, Xiaona Liu and Xiumei Duan

    Citation: Diagnostic Pathology 2019 14:116

    Content type: Case Report

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  15. Primary cutaneous CD30+ lymphoproliferative disorders (pc-CD30-LPD) are a group of clonal T cell lymphoproliferative disorders that despite very similar tumor histology follow different and characteristic clin...

    Authors: Cristiane Rúbia Ferreira, Shuchun Zhao, José Antonio Sanches, Denis Miyashiro, Jade Cury-Martins, Raymundo Soares Azevedo, Maria C. N. Zerbini, Yasodha Natkunam and Dita Gratzinger

    Citation: Diagnostic Pathology 2019 14:115

    Content type: Research

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  16. Recent studies have shown that T cell-mediated cellular immune mechanisms play important roles in the progression of hepatitis B to liver cirrhosis, but the underlying mechanisms remain unclear. This present s...

    Authors: Yong-Ting Lan, Zhen-li Wang, Peng Tian, Xiao-Na Gong, Yu-Chen Fan and Kai Wang

    Citation: Diagnostic Pathology 2019 14:114

    Content type: Research

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  17. Rapid (“warm”) autopsies of patients with advanced metastatic cancer provide important insight into the natural history, pathobiology and histomorphology of disease in treatment-resistant tumors. Plasmacytoid ...

    Authors: Caroline T. Simon, Stephanie L. Skala, Paul D. Killen, Javed Siddiqui, Xuhong Cao, Yuanyuan Qiao, Hikmat Al-Ahmadie, Sandra I. Camelo-Piragua, Jeffrey Jentzen, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Zachery R. Reichert and Rohit Mehra

    Citation: Diagnostic Pathology 2019 14:113

    Content type: Case Report

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  18. Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. It was recognized as a group of emerging /provisional RCC ...

    Authors: Jing Yang, Lei Dong, Hong Du, Xiu-bo Li, Yan-xiao Liang and Guo-rong Liu

    Citation: Diagnostic Pathology 2019 14:112

    Content type: Case Report

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  19. Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor, commonly occurring in distal extremities, such as fingers, hands and wrists. For oncologists and surgeons, a female patient with enlarged axillar...

    Authors: Luyan Chen, Li Wang, Xiaochen Zhang, Minya Yao and Peifen Fu

    Citation: Diagnostic Pathology 2019 14:111

    Content type: Case Report

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  20. Low-grade endometrial stromal sarcoma (ESS) is rare mesenchymal neoplasm, recently specified as harboring JAZF1–SUZ12 rearrangement. Typical JAZF1–SUZ12 ESS is slow growing, in which high uptake of fluorodeoxyglu...

    Authors: Koto Fujiishi, Shigenori Nagata, Rieko Kano, Chiaki Kubo, Maasa Shirayanagi, Megumi Ozaki, Takashi Yamamoto, Katsuyuki Nakanishi, Shoji Kamiura and Shin-ichi Nakatsuka

    Citation: Diagnostic Pathology 2019 14:110

    Content type: Case Report

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  21. Laryngeal squamous cell carcinoma (LSCC) is considered to be a common malignancy of the head and neck with poor prognosis for its late diagnosis, metastasis and recurrence. Growing evidence demonstrates that t...

    Authors: Ruihua Fang, Yongjin Huang, Jinghua Xie, Jianzhong Zhang and Xiaobin Ji

    Citation: Diagnostic Pathology 2019 14:109

    Content type: Research

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  22. Mcl-1, an anti-apoptotic member of bcl-2 family, together with cleaved poly (ADC-ribose) polymerase (c-PARP) can serve as a marker of cell apoptosis. Previously we reported that treatment of Mnk inhibitor CGP5...

    Authors: Qiuyuan Wen, Yuting Zhan, Hongmei Zheng, Hongjing Zang, Jiadi Luo, Yuting Zhang, Weiyuan Wang, Juan Feng, Junmi Lu, Lingjiao Chen and Songqing Fan

    Citation: Diagnostic Pathology 2019 14:108

    Content type: Research

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  23. High ERCC1 expression is thought to be related with resistance to chemotherapy based on platinum. The aim of this study was to present our institutional observations regarding to the association of ERCC1 and o...

    Authors: Marina Piljić Burazer, Suzana Mladinov, Antonela Matana, Sendi Kuret, Joško Bezić and Merica Glavina Durdov

    Citation: Diagnostic Pathology 2019 14:105

    Content type: Research

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  24. The category of grade 3 neuroendocrine tumor (NET G3) was newly introduced in the 2017 World Health Organization (WHO 2017) classification of neuroendocrine neoplasms of the pancreas. Pancreatic NET G3 shows a...

    Authors: Kenji Inafuku, Tomoyuki Yokose, Hiroyuki Ito, Daisuke Eriguchi, Joji Samejima, Takuya Nagashima, Haruhiko Nakayama, Masaki Suzuki, Kouzo Yamada and Munetaka Masuda

    Citation: Diagnostic Pathology 2019 14:104

    Content type: Case Report

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  25. The most frequent histological types of rhabdomyosarcoma (RMS) in children are embryonal (ERMS) and alveolar (ARMS) tumours. The majority of ARMS are characterized by the presence of PAX3/7-FOXO1 gene fusion a...

    Authors: Magdalena Kaleta, Anna Wakulińska, Agnieszka Karkucińska-Więckowska, Bożenna Dembowska-Bagińska, Wiesława Grajkowska, Maciej Pronicki and Maria Łastowska

    Citation: Diagnostic Pathology 2019 14:103

    Content type: Research

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  26. Basaloid squamous cell carcinoma (BSCC) is a rare subtype of squamous cell carcinoma with a high rate of distant metastasis. BSCC occurs most commonly in the esophagus, lungs, and head and neck. However, BSCC ...

    Authors: Linxiu Liu, Xuemin Xue and Liyan Xue

    Citation: Diagnostic Pathology 2019 14:102

    Content type: Case Report

    Published on:

  27. The accurate identification of the tissue of origin is critical for optimal management of cancer patients particularly those who develop multiple malignancies; however, conventional diagnostic methods at times...

    Authors: Chuangzhou Rao, Liangqin Nie, Xiaobo Miao, Analyn Lizaso and Guofang Zhao

    Citation: Diagnostic Pathology 2019 14:101

    Content type: Case Report

    Published on:

  28. Antibodies targeting the programmed cell death-1 (PD-1)/PD-ligand 1 (PD-1/PD-L1) checkpoint have shown promising clinical activity in patients with advanced urothelial carcinoma (UC). Expression of PD-L1 in UC...

    Authors: Magdalena Zajac, Marietta Scott, Marianne Ratcliffe, Paul Scorer, Craig Barker, Hytham Al-Masri, Marlon C. Rebelatto and Jill Walker

    Citation: Diagnostic Pathology 2019 14:99

    Content type: Research

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  29. Celiac disease (CD) is characterized histologically by inflammation and villous atrophy. Villous atrophy is thought to result from a disruption of epithelial cellular proliferation and death. Epithelial cells ...

    Authors: Michael Lee, Shane Betman, Alina Iuga, Hui-Min Yang, Jude Fleming, Peter H. R. Green, Benjamin Lebwohl and Stephen M. Lagana

    Citation: Diagnostic Pathology 2019 14:98

    Content type: Research

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  30. Ovarian metastatic tumors from lung adenocarcinoma are rare, and a serial study of these tumors is lacking to date. Additionally, a better understanding of the clinicopathological and molecular characteristics...

    Authors: Rui Bi, Qianming Bai, Xiaoli Zhu, Xiaoyu Tu, Xu Cai, Wenhua Jiang, Xiaoli Xu, Shaoxian Tang, Huijuan Ge, Bin Chang, Yufan Cheng, Hualei Gan, Xiaoyan Zhou and Wentao Yang

    Citation: Diagnostic Pathology 2019 14:96

    Content type: Research

    Published on:

  31. Secretory breast carcinoma is an exceptionally rare type of breast carcinoma. Only 5 cases of pure secretory carcinoma in situ have been reported in English literature. Herein, we reported a rare case of pure ...

    Authors: Ying Yang, Zhiyuan Wang, Guoqing Pan, Shumo Li, Yingying Wu and Liu Liu

    Citation: Diagnostic Pathology 2019 14:95

    Content type: Case Report

    Published on:

  32. Castleman’s disease (CD) is an uncommon type of benign proliferation of the lymphoid tissue, characterized by local or systemic lymphadenopathy that most frequently appears in the mediastinum; involvement of t...

    Authors: Yunzhu Li, Haixia Zhao, Bingyin Su, Chan Yang, Shurong Li and Wanlei Fu

    Citation: Diagnostic Pathology 2019 14:94

    Content type: Case Report

    Published on:

  33. A primordial odontogenic tumor (POT) is a rare, benign, mixed epithelial and mesenchymal odontogenic tumor that has been included as a new entity in the latest World Health Organization (WHO) classification (2...

    Authors: Qiaochu Sun, Jae-Seo Lee, Okjoon Kim and Young Kim

    Citation: Diagnostic Pathology 2019 14:92

    Content type: Case Report

    Published on:

  34. European treatment guidelines for pTa and pT1 urinary bladder urothelial carcinoma depend highly on stage and WHO-grade. Both the WHO73 and the WHO04 grading systems show some intra- and interobserver variabil...

    Authors: Vebjørn Kvikstad, Ok Målfrid Mangrud, Einar Gudlaugsson, Ingvild Dalen, Hans Espeland, Jan P. A. Baak and Emiel A. M. Janssen

    Citation: Diagnostic Pathology 2019 14:90

    Content type: Research

    Published on:

  35. Follicular dendritic cell sarcoma (FDCS) is a rare malignancy. In addition to the classical histopathologic features, it has also some special morphological variants that can present a challenge in the diagnos...

    Authors: You-Li Wu, Feng Wu, Robinson Ateh Mbako, Yu Zhang, Guang-Jie Duan and Xiao-Chu Yan

    Citation: Diagnostic Pathology 2019 14:89

    Content type: Case Report

    Published on:

  36. Tumor-to-tumor metastasis (TTM) is a rare but well-documented phenomenon that is defined as metastasis in a histologically distinct tumor. Ovarian mature teratomas (OMTs) can coexist with various cancers by ma...

    Authors: Mitsutake Yano, Tomomi Katoh, Tetsuya Hamaguchi, Eito Kozawa, Mei Hamada, Koji Nagata and Masanori Yasuda

    Citation: Diagnostic Pathology 2019 14:88

    Content type: Case Report

    Published on:

  37. Following publication of the original article [1], the authors reported an added data on Table 1 in their paper. The original article [1] has been updated.

    Authors: C. Elfgen, B. Papassotiropoulos, Z. Varga, L. Moskovszky, M. Nap, U. Güth, A. Baege, E. Amann, F. Chiesa and C. Tausch

    Citation: Diagnostic Pathology 2019 14:87

    Content type: Correction

    Published on:

    The original article was published in Diagnostic Pathology 2019 14:58

  38. Solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic type, and it develops in almost any part of the human body. However, according to previous studies, the occurrence of intravascular SFTs is...

    Authors: Jingyuan Fan, Jinfeng Qiu and Qingjun Wei

    Citation: Diagnostic Pathology 2019 14:86

    Content type: Case Report

    Published on:

  39. At the 3rd week of human embryo, some cell clumps are formed by the hyperplasia of mesenchymal cells at the germ layer of the yolk sac wall. These cell clumps are known as blood islands. The cells in the cente...

    Authors: Jianhong An, Yufeng Zhang, Jiao Luo and Hong Shen

    Citation: Diagnostic Pathology 2019 14:85

    Content type: Case Report

    Published on:

  40. CRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course. Primary MEC of the liver is an extremely rare,...

    Authors: Jiro Watanabe, Keita Kai, Ken Tanikawa, Mamoru Hiraki, Naohisa Mizukami, Shinichi Aishima, Takafumi Nakano and Hidetaka Yamamoto

    Citation: Diagnostic Pathology 2019 14:84

    Content type: Case Report

    Published on:

  41. Atypical multinucleated stromal giant cells (MSGCs) are occasionally encountered in the esophagogastric mucosa. This study aims to investigate the origin and clinical association of MSGCs in the upper gastroin...

    Authors: Taha Sachak, Wendy L. Frankel, Christina A. Arnold and Wei Chen

    Citation: Diagnostic Pathology 2019 14:83

    Content type: Research

    Published on:

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