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  1. Case Report

    A novel GIT2-BRAF fusion in pilocytic astrocytoma

    KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions o...

    Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon and Sanda Alexandrescu

    Diagnostic Pathology 2017 12:82

    Published on: 15 November 2017

  2. Research

    Automated quantification of steatosis: agreement with stereological point counting

    Steatosis is routinely assessed histologically in clinical practice and research. Automated image analysis can reduce the effort of quantifying steatosis. Since reproducibility is essential for practical use, ...

    André Homeyer, Patrik Nasr, Christiane Engel, Stergios Kechagias, Peter Lundberg, Mattias Ekstedt, Henning Kost, Nick Weiss, Tim Palmer, Horst Karl Hahn, Darren Treanor and Claes Lundström

    Diagnostic Pathology 2017 12:80

    Published on: 13 November 2017

  3. Case Report

    Sclerosing angiomatoid nodular transformation of the spleen in a patient with Maffucci syndrome: a case report and review of literature

    Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia characterized by multiple enchondromas and hemangiomas. The presence of visceral vascular lesions in this syndrome is exceedingly rare.

    Xiao-Dan Huang, Hao-Sen Jiao, Zheng Yang, Chuang-Qi Chen, Yu-Long He and Xin-Hua Zhang

    Diagnostic Pathology 2017 12:79

    Published on: 10 November 2017

  4. Case Report

    Complete mimicry: a case of alveolar rhabdomyosarcoma masquerading as acute leukemia

    A small number of rhabdomyosarcoma (RMS) cases involve the bone marrow. A leukemic presentation of RMS has been reported in a few case series, although almost all cases of leukemic RMS are not completely mimic...

    Osamu Imataki, Makiko Uemura, Shumpei Uchida, Shigeyuki Yokokura, Akihiro Takeuchi, Ryo Ishikawa, Akihiro Kondo, Kayoko Seo and Norimitsu Kadowaki

    Diagnostic Pathology 2017 12:77

    Published on: 2 November 2017

  5. Case Report

    Spontaneous isolated dissection of the superior mesenteric artery and aneurysm formation resulting from segmental arterial mediolysis: a case report

    Spontaneous isolated dissection of the superior mesenteric artery (SMA) can lead to bowel ischemia, aneurysm rupture, or even death. Studies have suggested that mechanical or hemodynamic stress on the vascular...

    Nobuhiro Akuzawa, Makoto Kurabayashi, Tsukasa Suzuki, Daisuke Yoshinari, Mitsunobu Kobayashi, Yoshifumi Tanahashi, Fujio Makita and Ryusei Saito

    Diagnostic Pathology 2017 12:74

    Published on: 16 October 2017

  6. Research

    PD-L1 and PD-1 expression are correlated with distinctive clinicopathological features in papillary thyroid carcinoma

    Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary...

    Yanhua Bai, Dongfeng Niu, Xiaozheng Huang, Ling Jia, Qiang Kang, Fangyuan Dou, Xinqiang Ji, Weicheng Xue, Yiqiang Liu, Zhongwu Li, Qin Feng, Dongmei Lin and Kennichi Kakudo

    Diagnostic Pathology 2017 12:72

    Published on: 3 October 2017

  7. Case Report

    Primary paranasal sinus hyalinizing clear cell carcinoma: a case report

    Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumour of salivary glands that was first described as a distinct entity in 1994 by Milchgrub et al. EWSR1-ATF1 fusion was found to be specific for this ...

    Batool M. AlAli, Mohammed J. Alyousef, Ahmad Salah Kamel, Mohammad A. Al hamad, Mohammad H. Al-Bar and Roaa M. Algowiez

    Diagnostic Pathology 2017 12:70

    Published on: 25 September 2017

  8. Research

    Data integration from pathology slides for quantitative imaging of multiple cell types within the tumor immune cell infiltrate

    Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states and loca...

    Zhaoxuan Ma, Stephen L. Shiao, Emi J. Yoshida, Steven Swartwood, Fangjin Huang, Michael E. Doche, Alice P. Chung, Beatrice S. Knudsen and Arkadiusz Gertych

    Diagnostic Pathology 2017 12:69

    Published on: 18 September 2017

  9. Methodology

    Computer-assisted stereology and automated image analysis for quantification of tumor infiltrating lymphocytes in colon cancer

    Precise prognostic and predictive variables allowing improved post-operative treatment stratification are missing in patients treated for stage II colon cancer (CC). Investigation of tumor infiltrating lymphoc...

    Ann C. Eriksen, Johnnie B. Andersen, Martin Kristensson, René dePont Christensen, Torben F. Hansen, Sanne Kjær-Frifeldt and Flemming B. Sørensen

    Diagnostic Pathology 2017 12:65

    Published on: 29 August 2017

  10. Research

    Immunohistochemical staining with non-phospho β-catenin as a diagnostic and prognostic tool of COX-2 inhibitor therapy for patients with extra-peritoneal desmoid-type fibromatosis

    Immunohistochemical staining with conventional anti-β-catenin antibody has been applied as a diagnostic tool for desmoid-type fibromatosis (DF). This study aimed to evaluate the diagnostic and prognostic value...

    Tomohisa Sakai, Yoshihiro Nishida, Shunsuke Hamada, Hiroshi Koike, Kunihiro Ikuta, Takehiro Ota and Naoki Ishiguro

    Diagnostic Pathology 2017 12:66

    Published on: 29 August 2017

  11. Case Report

    Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review

    Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the ...

    Hiroka Ando, Yuko Watanabe, Minori Ogawa, Hiromi Tamura, Tomomi Deguchi, Kayo Ikeda, Mayumi Fujitani, Mitsunori Shioji, Tomoko Tsujie, Reiko Doi, Akinori Wakimoto and Shiro Adachi

    Diagnostic Pathology 2017 12:63

    Published on: 25 August 2017

  12. Case Report

    A case of intravascular large B cell lymphoma presenting as nodular goiter

    Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is rare and highly aggressive and that may progressively involve many organs. CNS (central nervous system...

    Bo Luo, Jia-mei Chen, Jie Liu, Wen-he Li, Yu-xiang Shi, Pan Zeng, Yong-hui Xie and Hong-feng Zhang

    Diagnostic Pathology 2017 12:64

    Published on: 25 August 2017

  13. Research

    Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation

    Ciliated muconodular papillary tumors (CMPTs) are newly recognized rare peripheral lung nodules that are histologically characterized by ciliated columnar, goblet, and basal cells. Although recent studies have...

    Emiko Udo, Bungo Furusato, Kazuko Sakai, Leah M Prentice, Tomonori Tanaka, Yuka Kitamura, Tomoshi Tsuchiya, Naoya Yamasaki, Takeshi Nagayasu, Kazuto Nishio and Junya Fukuoka

    Diagnostic Pathology 2017 12:62

    Published on: 22 August 2017

  14. Review

    Pleural epithelioid angiosarcoma with lymphatic differentiation arisen after radiometabolic therapy for thyroid carcinoma: immunohistochemical findings and review of the literature

    Pleural angiosarcoma is a rare tumor that causes diffuse pleural thickening and effusion, mimicking mesothelioma. Immunohistochemistry is needed to highlight endothelial differentiation. We describe the first ...

    Daniela Cabibi, Giulia Pipitone, Rossana Porcasi, Sabrina Ingrao, Ignazio Benza, Calogero Porrello, Massimo Cajozzo and Antonino Giulio Giannone

    Diagnostic Pathology 2017 12:60

    Published on: 15 August 2017

  15. Research

    Gene expression profiling in uveal melanoma: technical reliability and correlation of molecular class with pathologic characteristics

    A 15-gene expression profile test has been clinically validated and is widely utilized in newly diagnosed uveal melanoma (UM) patients to assess metastatic potential of the tumor. As most patients are treated ...

    Kristen M. Plasseraud, Jeff K. Wilkinson, Kristen M. Oelschlager, Trisha M. Poteet, Robert W. Cook, John F. Stone and Federico A. Monzon

    Diagnostic Pathology 2017 12:59

    Published on: 4 August 2017

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