Articles

Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action

Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatal...

Authors: Amira Mohammed Ali and Hiroshi Kunugi

Undifferentiated colonic neoplasm with SMARCA4 germline gene mutation and loss of SMARCA4 protein expression: a case report and literature review

Nonsense mutation or inactivation of SMARCA4 (BRG1) is associated with a monomorphic undifferentiated histological appearance in tumors at different sites. The association between SMARCA4 alteration and undiff...

Authors: Huanli Duan, Wei Gao, Leiming Wang, Feng Cao and Lianghong Teng

Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma

Primary hepatic mucoepidermoid carcinoma (HMEC) is extremely rare and the molecular etiology is still unknown. The CRTC1-MAML2 fusion gene was previously detected in a primary HMEC, which is often associated with...

Authors: Ping Hou, Xiaoyan Su, Wei Cao, Liping Xu, Rongguiyi Zhang, Zhihao Huang, Jiakun Wang, Lixiang Li, Linquan Wu and Wenjun Liao

Significance of mesothelin and CA125 expression in endometrial carcinoma: a retrospective analysis

This study aimed to investigate the association between clinicopathologic factors, mesothelin, and cancer antigen (CA) 125 in endometrial carcinoma.

Authors: Soichiro Kakimoto, Morikazu Miyamoto, Takahiro Einama, Yasuhiro Takihata, Hiroko Matsuura, Hideki Iwahashi, Hiroki Ishibashi, Takahiro Sakamoto, Taira Hada, Jin Suminokura, Tsubasa Ito, Rie Suzuki, Ayako Suzuki and Masashi Takano

Let-7a-5p regulates the inflammatory response in chronic rhinosinusitis with nasal polyps

Let-7a-5p is demonstrated to be a tumor inhibitor in nasopharyngeal carcinoma. However, the role of let-7a-5p in chronic rhinosinusitis with nasal polyps (CRSwNP) has not been reported. This study is designed ...

Authors: Jianwei Zhang, Lei Han and Feng Chen

Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

TWIST1 and CD105, which contribute to tumor malignancy, are overexpressed in cancers. Accordingly, TWIST1 enhances epithelial-to-mesenchymal transition (EMT) and promotes the formation of cancer stem cells (CS...

Authors: Fahimeh Fattahi, Leili Saeednejad Zanjani, Somayeh Vafaei, Zohreh Habibi Shams, Jafar Kiani, Marzieh Naseri, Elmira Gheytanchi and Zahra Madjd

Diagnostic pitfall of thyroid fine-needle aspiration induced fibrosis: follicular adenoma mimicking medullary thyroid carcinoma in frozen section

Fine-needle aspiration (FNA) is a frequently utilized method for the diagnosis of thyroid nodules. Although the technique has clear advantages, the injury caused by the aspiration needle can induce various his...

Authors: Woo Sung Moon, Myoung Jae Kang, Hyun Jo Youn and Kyoung Min Kim

Artificial intelligence (AI) in medicine, current applications and future role with special emphasis on its potential and promise in pathology: present and future impact, obstacles including costs and acceptance among pathologists, practical and philosophical considerations. A comprehensive review

The role of Artificial intelligence (AI) which is defined as the ability of computers to perform tasks that normally require human intelligence is constantly expanding. Medicine was slow to embrace AI. However...

Authors: Zubair Ahmad, Shabina Rahim, Maha Zubair and Jamshid Abdul-Ghafar

Kaposiform Hemangioendothelioma: clinicopathological characteristics of 8 cases of a rare vascular tumor and review of literature

Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumor of intermediate malignant potential which shows locally aggressive growth but only rarely metastasizes. It is mostly considered to be a tumor of p...

Authors: Qurratulain Chundriger, Muhammad Usman Tariq, Jamshid Abdul-Ghafar, Arsalan Ahmed and Nasir Ud Din

Sialadenoma papilliferum: clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature

Sialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and...

Authors: Shuai Chen, Jie Peng, Chuantao Yuan, Lin Sun, Renya Zhang and Yan Sun

Next-generation sequencing facilitates differentiating between multiple primary lung cancer and intrapulmonary metastasis: a case series

In lung cancer management, differential diagnosis between multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IMP) is a critical point that is of direct therapeutic and clinical importance. Howe...

Authors: Changjiang Liu, Chengang Liu, Xiao Zou, Lin Shao, Ying Sun and Yang Guo

Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics

Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim ...

Authors: Pavel Dundr, Naveena Singh, Barbora Nožičková, Kristýna Němejcová, Michaela Bártů and Ivana Stružinská

Diagnosis prediction of tumours of unknown origin using ImmunoGenius, a machine learning-based expert system for immunohistochemistry profile interpretation

Immunohistochemistry (IHC) remains the gold standard for the diagnosis of pathological diseases. This technique has been supporting pathologists in making precise decisions regarding differential diagnosis and...

Authors: Yosep Chong, Nishant Thakur, Ji Young Lee, Gyoyeon Hwang, Myungjin Choi, Yejin Kim, Hwanjo Yu and Mee Yon Cho

Metastases can occur in cirrhotic livers with patent portal veins

Metastases are common in non-cirrhotic livers but are considered unlikely in the setting of cirrhosis. However, the degree of fibrosis in cirrhosis may vary; thus metastases may still access the liver vasculat...

Authors: Zaid Mahdi, Mark G. Ettel, Raul S. Gonzalez, John Hart, Lindsay Alpert, Jiayun Fang, Natalia Liu, Suntrea T. Hammer, Nicole Panarelli, Jerome Cheng, Joel K. Greenson, Paul E. Swanson and Maria Westerhoff

CpG islands in MyD88 and ASC/PYCARD/TMS1 promoter regions are differentially methylated in head and neck squamous cell carcinoma and primary lung squamous cell carcinoma

Patients with head and neck squamous cell carcinoma (HNSCC) can develop lung squamous cell carcinoma (LuSCC), which could be the second primary tumor or HNSCC metastasis. Morphologically it is difficult to dis...

Authors: Maja Šutić, Jurica Baranašić, Lana Kovač Bilić, Mario Bilić, Antonija Jakovčević, Luka Brčić, Sven Seiwerth, Marko Jakopović, Miroslav Samaržija, Ulrich Zechner and Jelena Knežević

From SARS-CoV-2 hematogenous spreading to endothelial dysfunction: clinical-histopathological study of cutaneous signs of COVID-19

To date, very few studies on clinical-histopathological correlations of cutaneous disorders associated with COVID-19 have been conducted.

Authors: Angela Patrì, Maria Vargas, Pasquale Buonanno, Maria Carmela Annunziata, Daniela Russo, Stefania Staibano, Giuseppe Servillo and Gabriella Fabbrocini

Endobronchial sialolipoma. Case report

A 52-year-old woman presented with shortness of breath and cough. An endobronchial sialolipoma was found at the left entrance of the main bronchus. Sialolipoma is an exceedingly rare type of lipoma reported of...

Authors: Severino Rey Nodar, Verónica García Yllán, Nohelia Rojas Ferrer, Onay Solis and Hugo D. Boccara

Succinate dehydrogenase deficient gastrointestinal stromal tumor in a three month old boy with a fatal clinical course: a case report and review of literature

Succinate dehydrogenase deficient gastrointestinal stromal tumors (SDH-deficient GISTs), which lack KIT or PDGFRA mutations demonstrate unique clinical and pathological features, and they respond poorly to sta...

Authors: Bei-Bei Lv, Jia-Mei Li, Zhi-Gang Yao, Xian-Kui Cheng, Fu-Xin Ren, Wen-Jing Su, Ye-Jun Qin, Zhou Wang and Zhi-xin Cao

Accuracy of HPV E6/E7 mRNA examination using in situ hybridization in diagnosing cervical intraepithelial lesions

The consistency of pathologists in the diagnosis of cervical intraepithelial neoplasia (CINs) is not ideal, especially between low- and high-grade squamous intraepithelial lesions (LSIL and HSIL). This study w...

Authors: Chang Hui, Huimin Bai, Jun Liu, Xuerong Lu, Shuzhen Wang, Zhenyu Zhang, Mulan Jin, Yue Wang and Yuzhen Liu

Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is the second subtype of ovarian epithelial carcinoma reported to be closely related to Lynch syndrome (LS). ARID1A mutation is an important pathogenetic mechanism in OCCC t...

Authors: Huijuan Ge, Yaoxin Xiao, Guangqi Qin, Yanzi Gu, Xu Cai, Wenhua Jiang, Xiaoyu Tu, Wentao Yang and Rui Bi

Title: pancreatic‐type mixed acinar neuroendocrine carcinoma of the stomach: a case report and review of the literature

The majority of gastrointestinal tumors are adenocarcinomas. Rarely, there are other types of tumors, such as acinar cell carcinoma, and these are often called pancreatic-type acinar cell carcinomas. Among the...

Authors: Yuka Ooe, Kishichiro Watanabe, Isaya Hashimoto, Satoshi Takenaka, Toshihiko Ojima, Seiichi Yamamoto and Hisatake Fujii

Low GSTM3 expression is associated with poor disease‐free survival in resected esophageal squamous cell carcinoma

Glutathione S-transferase mu 3 (GSTM3) plays a crucial role in tumor progression in various cancers. However, the relationship between GSTM3 expression and the clinical prognosis of esophageal squamous cell ca...

Authors: Fu Yang, Jing Wen, Kongjia Luo and Jianhua Fu

Atypical cells parameter in Sysmex UN automated urine analyzer: feedback from the field

“Atypical cells” parameter in automated urinalysis has recently been introduced. An instrument capable of measuring quantitative and qualitative features of nuclear and cytoplasmic properties of a cell has the...

Authors: Ozgur Aydin

Placental pathology of the third trimester pregnant women from COVID-19

To explore the clinical characteristics and placental pathological changes of pregnant women with 2019 novel coronavirus (CoV) disease (COVID-19) in the third trimester, and to assess the possibility of vertic...

Authors: Likun Gao, Jiacai Ren, Li Xu, Xiaokang Ke, Lin Xiong, Xiaoli Tian, Cuifang Fan, Honglin Yan and Jingping Yuan

Aspiration biopsy versus dilatation and curettage for endometrial hyperplasia prior to hysterectomy

To compare the diagnostic accuracy of aspiration biopsy and dilatation and curettage (D&C) in patients diagnosed with endometrial hyperplasia prior to hysterectomy.

Authors: Woo Yeon Hwang, Dong Hoon Suh, Kidong Kim, Jae Hong No and Yong Beom Kim

Nodal histiocytic sarcoma with prominent eosinophilic infiltration: expression of eotaxin-2 on tumor cells

Histiocytic sarcoma (HS) is a rare neoplasm showing morphological and immunophenotypic features of mature tissue histiocytes. We report a patient with nodal HS exhibiting prominent reactive eosinophilic infilt...

Authors: Rintaro Ohe, Takanobu Kabasawa, Aya Utsunomiya, Yuka Urano, Takumi Kitaoka, Kazushi Suzuki, Naing Ye Aung, Ichiro Kawamura, Katsushi Tajima, Tomoharu Ishiyama and Mitsunori Yamakawa

High miR-324-5p expression predicts unfavorable prognosis of gastric cancer and facilitates tumor progression in tumor cells

Gastric cancer (GCa) is one of the six major malignancies in the world with low survival rate. Although there are advances in therapeutic approaches, the prognosis of patients with GCa remains not optimistic. ...

Authors: Zhong Zheng, Jun Li, Junyan An, Yikuan Feng and Lirong Wang

An “expressionistic” look at serrated precancerous colorectal lesions

Approximately 60% of colorectal cancer (CRC) precursor lesions are the genuinely-dysplastic conventional adenomas (cADNs). The others include hyperplastic polyps (HPs), sessile serrated lesions (SSL), and trad...

Authors: Giancarlo Marra

Primary dedifferentiated Liposarcoma of vagina: a first case report

Dedifferentiated liposarcoma, one of the most deadly types of soft tissue sarcoma, is an aggressive and high-grade form of liposarcoma. Liposarcoma occurs most commonly in the retroperitoneum, extremities and ...

Authors: Chuan Xie and Yangmei Shen

Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum

IL4Rα and IL13Rα1 are constituents of the type II IL4 receptor. Recently, IL4Rα and IL13Rα1 were reported to have roles in cancer progression and suggested as potential prognostic markers. However, studies on ...

Authors: Kyoung Min Kim, Usama Khamis Hussein, See-Hyoung Park, Young Jae Moon, Zhongkai Zhang, Asmaa Gamal Ahmed, Ae-Ri Ahn, Ho Sung Park, Jung Ryul Kim and Kyu Yun Jang

The clinicopathological relevance of uniform CD56 expression in anaplastic large cell lymphoma: a retrospective analysis of 18 cases

Anaplastic large cell lymphoma (ALCL) with uniform CD56 expression is a rare condition, that has been described in limited literature, and its clinicopathological features have not yet been well illustrated. T...

Authors: Bao-Hua Yu, Yan Zhang, Tian Xue, Ruo-Hong Shui, Hong-Fen Lu, Xiao-Yan Zhou, Xiong-Zeng Zhu and Xiao-Qiu Li

Quality assessment of a clinical next-generation sequencing melanoma panel within the Italian Melanoma Intergroup (IMI)

Identification of somatic mutations in key oncogenes in melanoma is important to lead the effective and efficient use of personalized anticancer treatment. Conventional methods focus on few genes per run and, ...

Authors: Irene Vanni, Milena Casula, Lorenza Pastorino, Antonella Manca, Bruna Dalmasso, Virginia Andreotti, Marina Pisano, Maria Colombino, Ulrich Pfeffer, Enrica Teresa Tanda, Carla Rozzo, Panagiotis Paliogiannis, Antonio Cossu, Paola Ghiorzo and Giuseppe Palmieri

Parathyroid carcinoma with sarcomatoid differentiation: a case report and literature review

Parathyroid carcinoma (PC) is a rare thyroid tumor. PC with sarcomatoid differentiation(PCSD) is even rarer and its exact etiology remains unclear. We here report a case of PCSD, and present the clinicopatholo...

Authors: Liang Hu and Xiaojun Xie

Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway

The involvement of circular RNAs (circRNAs) in chemoresistance of tumors has been identified. Herein, this study aims to investigate the role and the underlying mechanism of circ_0003998 in doxorubicin (DOX) r...

Authors: Xiaomin Li, Jiefeng He, Xiaojing Ren, Haichao Zhao and Haoliang Zhao

Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification

The histological discrimination of hyperplastic polyps from sessile serrated lesions can be difficult. Sessile serrated lesions and hyperplastic polyps are types of serrated polyps which confer different malig...

Authors: Diana R. Jaravaza and Jonathan M. Rigby

Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature

Pancreatic Solid Pseudopapillary Neoplasms (SPNs) are rare low-grade malignant tumors with a marked preponderance for young females. Objective was to describe the morphology, differential diagnosis, and progno...

Authors: Nasir Ud Din, Shabina Rahim, Jamshid Abdul-Ghafar, Arsalan Ahmed and Zubair Ahmad

Comment on: Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

Authors: Siamak Sabour

Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast

High grade basal-like breast carcinomas are triple negative, express basal cytokeratins, and are known for the overall poor prognosis and aggressive behavior. HPV related multiphenotypic sino-nasal carcinoma h...

Authors: Diana M. Oramas, Diana Bell and Lavinia P. Middleton

Non coding RNAs as the critical factors in chemo resistance of bladder tumor cells

Bladder cancer (BCa) is the ninth frequent and 13th leading cause of cancer related deaths in the world which is mainly observed among men. There is a declining mortality rates in developed countries. Although...

Authors: Amir Sadra Zangouei, Hamid Reza Rahimi, Majid Mojarrad and Meysam Moghbeli

KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics

Karyopherin α2 (KPNA2), a member of the karyopherin α family, has been studied in several cancers but has not yet been substantially investigated in malignant bone tumors. The purpose of the current study was ...

Authors: Lucen Jiang, Jianghuan Liu, Qingzhu Wei and Yiyang Wang

P63-negative pulmonary NUT carcinoma arising in the elderly: a case report

Pulmonary NUT carcinoma is rare, but lethal, thus, must not be overlooked. The definitive diagnosis is made by a NUT monoclonal antibody or gene analysis, but these are not always routinely available. Therefor...

Authors: Satoe Numakura, Koji Saito, Noriko Motoi, Taisuke Mori, Yuichi Saito, Fumi Yokote, Yasuyuki Kanamoto, Momoko Asami, Takashi Sakai, Yoshikane Yamauchi, Yukinori Sakao, Hiroshi Uozaki and Masafumi Kawamura

Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3

Lung cancer (LC) is a malignant tumor originating in the bronchial mucosa or gland of the lung. Circular RNAs (circRNAs) are proved to be key regulators of tumor progression. However, the regulatory effect of ...

Authors: Koudong Zhang, Hang Hu, Juan Xu, Limin Qiu, Haitao Chen, Xingzhi Jiang and Yongqian Jiang

Giant lung metastasis of NRAS-mutant melanoma in a 24-year-old patient with a history of BRAF-mutant conventional melanoma harboring Spitzoid morphology: a case report

Spitzoid melanocytic lesions represent a heterogeneous group of proliferations with ambiguous and overlapping terminology. The exact distinction of a Spitz nevus from a Spitzoid melanoma can be very difficult ...

Authors: Jiri Vachtenheim Jr, Roman Kodet, Ondrej Fischer, Vitezslav Kolek, Zuzana Strizova, Andrej Ozaniak, Jan Simonek, Alan Stolz, Jiri Pozniak, Jan Kolarik, Monika Svorcova, Jiri Vachtenheim and Robert Lischke

Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection

Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the ...

Authors: Chengfang Li, Xinglong Wu, Shuang Yang, Xiaorong Yang, Jin Yao and Hong Zheng

Detection and stage classification of Plasmodium falciparum from images of Giemsa stained thin blood films using random forest classifiers

The conventional method for the diagnosis of malaria parasites is the microscopic examination of stained blood films, which is time consuming and requires expertise. We introduce computer-based image segmentat...

Authors: Syed Saiden Abbas and Tjeerd M. H. Dijkstra

Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension

Histologic features of idiopathic non-cirrhotic portal hypertension (INCPH) may overlap with those without INCPH. Recently, these features have been recognized as part of the larger spectrum of porto-sinusoida...

Authors: Michel Kmeid, Chunlai Zuo, Stephen M. Lagana, Won-Tak Choi, Jingmei Lin, Zhaohai Yang, Xiuli Liu, Maria Westerhoff, M. Isabel Fiel, Kajsa Affolter, Eun-Young K. Choi and Hwajeong Lee

Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma

Colorectal T/natural killer (NK)-cell lymphomas (TNKCL) are very rare. Endoscopic and clinicopathological characteristics of colorectal TNKCL have not been clearly demonstrated. In this study, we demonstrated ...

Authors: Hideki Ishibashi, Satoshi Nimura, Fumihito Hirai, Naohiko Harada, Hiromi Iwasaki, Sigeto Kawauchi, Yumi Oshiro, Atsuji Matsuyama, Shotaro Nakamura, Yasushi Takamatsu, Hirotoshi Yonemasu, Taturo Shimokama and Morishige Takeshita

Diagnostic value of clusterin immunostaining in hepatocellular carcinoma

Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenge. Existing biomarkers are of limited diagnostic value. Our previous ...

Authors: Yuan Li, Fangfang Liu, Wendi Zhou, Sharon Zhang, Peiguo Chu, Fan Lin and Hanlin L. Wang

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenes...

Authors: Hong Kyu Lee, Mi Jung Kwon, Yong Joon Ra, Hee Sung Lee, Hyoung Soo Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Kyueng-Whan Min and So Young Kang

T-cell lymphoma with a granulomatous lesion of the lungs after autologous hematopoietic stem cell transplantation for Epstein–Barr virus-positive diffuse large B-cell lymphoma: a unique rare case of metachronous B-cell and T-cell lymphoma

Epstein–Barr virus (EBV) is associated with the pathogenesis of a variety of malignancies, most notably lymphomas. Especially in the background of immunodeficiency, such as primary immunodeficiency disorder (P...

Authors: Yusuke Kajimoto, Yasuhiro Terasaki, Mika Terasaki, Shinobu Kunugi, Yugo Okabe, Satoshi Wakita, Koiti Inokuchi and Akira Shimizu