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COVID-19 and impact on peer review

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  1. Targeted next generation sequencing (NGS) technology to assess the mutational status of multiple genes on formalin-fixed, paraffin embedded (FFPE) tumors is rapidly being adopted in clinical settings, where qu...

    Authors: Catherine I. Dumur, Jorge A. Almenara, Celeste N. Powers and Andrea Ferreira-Gonzalez
    Citation: Diagnostic Pathology 2015 10:169
    Content type: Research Published on:

  2. Osteosarcoma is the most common primary bone malignancy with high local aggressiveness and rapid metastasizing potential, resulting in poor survival. Increasing reports suggest that deregulated microRNAs (miRNAs)...

    Authors: Afshin Taheriazam, Reza Bahador, Seyyed Hasan Karbasy, Seyed Mir Mansoor Moazen Jamshidi, Ali Torkaman, Emad Yahaghi and Mohammadreza Shakeri
    Citation: Diagnostic Pathology 2015 10:166
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:111

  3. Testicular germ cell tumors (TGCT) are the most common cancer entities in young men with increasing incidence observed in the last decades. For therapeutic management it is important, that TGCT are divided int...

    Authors: Niklas Klümper, Isabella Syring, Anne Offermann, David Adler, Wenzel Vogel, Stefan C. Müller, Jörg Ellinger, Arne Strauß, Heinz Joachim Radzun, Philipp Ströbel, Johannes Brägelmann, Sven Perner and Felix Bremmer
    Citation: Diagnostic Pathology 2015 10:165
    Content type: Research Published on:

  4. Pulmonary adenoid cystic carcinoma (PACC) is an uncommon neoplasm of the lung but represents the predominant type of salivary gland-type lung carcinoma. Only a few studies have focused on the genetic events as...

    Authors: Zhen Huo, Huanwen Wu, Shanqing Li and Zhiyong Liang
    Citation: Diagnostic Pathology 2015 10:161
    Content type: Short report Published on:

  5. Alveolar soft part sarcoma (ASPS) is a rare, malignant mesenchymal tumor of distinctive clinical, morphologic, ultrastructural, and cytogenetical characteristics. It typically arises in the extremities of adol...

    Authors: Ming Zhao, Qiu Rao, Cuiyun Wu, Zhongsheng Zhao, Xianglei He and Guoqing Ru
    Citation: Diagnostic Pathology 2015 10:160
    Content type: Case Report Published on:

  6. The efficacy of histological analysis of colon sections used for evaluation of inflammation severity can be improved by means of digital imaging giving quantitative estimates of main diagnostic features. The a...

    Authors: Robertas Petrolis, Rima Ramonaitė, Dainius Jančiauskas, Juozas Kupčinskas, Rokas Pečiulis, Limas Kupčinskas and Algimantas Kriščiukaitis
    Citation: Diagnostic Pathology 2015 10:159
    Content type: Research Published on:

  7. We report an unusual case of a 70-year-old male with history of hereditary spherocytosis (HS) and secondary paraspinal extramedullary hematopoiesis with a concurrent follicular lymphoma. The lesion presented a...

    Authors: Ricardo Molina-Urra, Daniel Martinez, Amaia Sagasta, Ana Carrio, Xavier Setoain, Benet Nomdedeu and Elias Campo
    Citation: Diagnostic Pathology 2015 10:158
    Content type: Case Report Published on:

  8. The observed controversy that N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211), a selective serotonin (5-HT7) receptor agonist, may either modify or exacerbate imbalances in serum electrolyt...

    Authors: Abbas Norouzi-Javidan, Javad Javanbakht, Fardin Barati, Nahid Fakhraei, Fatemeh Mohammadi and Ahmad Reza Dehpour
    Citation: Diagnostic Pathology 2015 10:157
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:108

  9. Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation be...

    Authors: Marius Lund-Iversen, Krystyna Kotanska Grøholt, Åslaug Helland, Elin Borgen and Odd Terje Brustugun
    Citation: Diagnostic Pathology 2015 10:156
    Content type: Short report Published on:

  10. Solitary fibrous tumor (SFT) is a rare neoplasm composed of mesenchymal-derived spindle cells. Although SFT occurs anywhere in the body, they most frequently affects the thoracic region. Here, we reported an e...

    Authors: Osamu Ichiyanagi, Hiromi Ito, Satoshi Takai, Sei Naito, Tomoyuki Kato, Akira Nagaoka and Mitsunori Yamakawa
    Citation: Diagnostic Pathology 2015 10:155
    Content type: Case Report Published on:

  11. A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-yea...

    Authors: Kieko Hara, Yuki Fukumura, Tsuyoshi Saito, Atsushi Arakawa, Hitomi Okabe, Satoru Takeda and Takashi Yao
    Citation: Diagnostic Pathology 2015 10:154
    Content type: Case Report Published on:

  12. Chronic pulmonary aspergillosis (CPA) has been accepted the criteria for the diagnosis of pulmonary Aspergillus infection. Whereas, either pathophysiology or signs of CPA remains still controversial.

    Authors: Naobumi Tochigi, Takao Ishiwatari, Yoichiro Okubo, Tsunehiro Ando, Minoru Shinozaki, Kyoko Aki, Kyoko Gocho, Yoshinobu Hata, Somay Y. Murayama, Megumi Wakayama, Tetsuo Nemoto, Yasuhiro Hori and Kazutoshi Shibuya
    Citation: Diagnostic Pathology 2015 10:153
    Content type: Research Published on:

  13. HIV-associated primary CNS lymphomas are well-recognized, almost exclusively EBV-driven neoplasms with poor clinical prognosis. We report a challenging, atypical case of an HIV-associated lymphoproliferative d...

    Authors: Isaac E. Lloyd, Parker W. Clement, Karen L. Salzman, Randy L. Jensen, Mohamed E. Salama and Cheryl A. Palmer
    Citation: Diagnostic Pathology 2015 10:152
    Content type: Case Report Published on:

  14. Immunohistochemical analysis of cellular interactions in the bone marrow in situ is demanding, due to its heterogeneous cellular composition, the poor delineation and overlap of functional compartments and hig...

    Authors: Cleo-Aron Weis, Benedict Walter Grießmann, Christoph Scharff, Caecilia Detzner, Eva Pfister, Alexander Marx and Frank Gerrit Zoellner
    Citation: Diagnostic Pathology 2015 10:151
    Content type: Methodology Published on:

  15. Pseudomyogenic hemangioendothelioma is an extremely rare soft tissue tumor, also named as epithelioid sarcoma-like hemangioendothelioma, which occurs more frequently in young adult males. It was originally rec...

    Authors: Chuifeng Fan, Lianhe Yang, Xuyong Lin and Enhua Wang
    Citation: Diagnostic Pathology 2015 10:150
    Content type: Case report Published on:

  16. Hepatocellular carcinoma (HCC) is one of the most frequent cancers in the world. Calreticulin(CRT) is aberrantly overexpressed in many human cancer cells. The function of CRT in HCC cells remains unclear. We a...

    Authors: Ruo Feng, Jianwen Ye, Chuang Zhou, Lei Qi, Zhe Fu, Bing Yan, Zhiwei Liang, Renfeng Li and Wenlong Zhai
    Citation: Diagnostic Pathology 2015 10:149
    Content type: Research Published on:

  17. PTEN is a tumor suppressor gene that regulates the PTEN/PI3k/AKT/mTOR pathway, which is frequently altered in human cancers including gallbladder cancer (GBC). To determine the frequency of PTEN expression in ...

    Authors: Iván Roa, Gonzalo de Toro, Fernanda Fernández, Anakaren Game, Sergio Muñoz, Xabier de Aretxabala and Milind Javle
    Citation: Diagnostic Pathology 2015 10:148
    Content type: Research Published on:

  18. Depletion of Poly-C binding protein-1(PCBP1) is implicated in various human malignancies. However, the underlying biological effect of PCBP1 in cancers, including acute myeloid leukemia (AML), still remains el...

    Authors: Meifeng Zhou and Xiuzhen Tong
    Citation: Diagnostic Pathology 2015 10:147
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:69

  20. The aim of this study was to describe the clinicopathological characteristics and high-risk human papillomavirus (HPV) infection status in patients diagnosed with co-existing of adenoid cystic carcinoma (ACC) ...

    Authors: Xiaohua Shi, Shafei Wu, Zhen Huo, Qing Ling, Yufeng Luo and Zhiyong Liang
    Citation: Diagnostic Pathology 2015 10:145
    Content type: Research Published on:

  21. Previous studies have been inconsistent with respect to the reported associations between human epidermal growth factor receptor (HER-2/neu) overexpression in colorectal cancer. The aims of this meta-analysis ...

    Authors: Sheng-wen Wu, Cong-chao Ma and Wen-hui Li
    Citation: Diagnostic Pathology 2015 10:144
    Content type: Research Published on:

  22. The KIF5B-RET rearrangement is detected with the frequency of 1 ~ 2 % in ‘triple marker’-negative lung adenocarcinomas, i.e., EGFR, KRAS and EML4-ALK wild type. These mutational changes are known to be mutually e...

    Authors: Jeong-Oh Kim, Jieun Lee, Jung-Young Shin, Ji-Eun Oh, Chan-Kwon Jung, Jae Kil Park, Sook-Whan Sung, Sang-Ju Bae, Hyun-Jung Min, Dowon Kim, Jae Yong Park and Jin-Hyoung Kang
    Citation: Diagnostic Pathology 2015 10:143
    Content type: Research Published on:

  23. PEComas are a group of very rare mesenchymal neoplasms, which express myogenic and melanocytic markers, such as HMB-45 and actin. Situs inversus totalis represents a complete left to right side transposition o...

    Authors: Yang Han, Ting-ting Liu, Xue-shan Qiu, Qing-chang Li, Yi Zhao, Xiao-Yan Pang and En-hua Wang
    Citation: Diagnostic Pathology 2015 10:142
    Content type: Case report Published on:

  24. Hypercholesterolemia is one of the most common risk factors for Coronary Artery Disease (CAD), which is the leading cause of death worldwide. As Numb is an important regulating factor regarding intestinal chol...

    Authors: Mayila Abudoukelimu, Zhen-Yan Fu, Yang Xiang, Yi-Tong Ma, Qing Zhu, Minawaer Abudu, Dilare Adi, Yi-Ning Yang, Xiao-Mei Li, Xiang Xie, Fen Liu and Bang-Dang Chen
    Citation: Diagnostic Pathology 2015 10:141
    Content type: Research Published on:

  25. Immunoglobulin heavy chain (IgH) gene rearrangement test is a standard tool in diagnosing B-cell lymphoma. The BIOMED-2 multiplex PCR protocol has become the most commonly used laboratory method for detecting ...

    Authors: Danfei Xu, Zhuo Yang, Donghong Zhang, Wei Wu, Ye Guo, Qian Chen, Dongsheng Xu and Wei Cui
    Citation: Diagnostic Pathology 2015 10:140
    Content type: Research Published on:

  26. Anal canal adenoma is an extremely rare disease that has the potential to transform into a malignant tumor. We herein presented a rare case of metachronous multiple adenomas of the anal canal. A 48-year-old wo...

    Authors: Hiroaki Nozawa, Soichiro Ishihara, Teppei Morikawa, Junichiro Tanaka, Koji Yasuda, Kensuke Ohtani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama, Masashi Fukayama…
    Citation: Diagnostic Pathology 2015 10:139
    Content type: Case report Published on:

  27. Gliomas are aggressive tumors of the central nervous system that rely on production of growth factors for tumor progression. Interleukin 8 (IL-8) is up-regulated in gliomas to promote angiogenesis and prolifer...

    Authors: Hao Liu, Ping Mao, Changhou Xie, Wanfu Xie, Maode Wang and Haitao Jiang
    Citation: Diagnostic Pathology 2015 10:138
    Content type: Research Published on:

  28. Gallbladder cancer is the most common biliary tract malignancy with the worst overall prognosis. CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling. In this study, CD109 protein expression in thre...

    Authors: Fengyun Dong, Chuanfeng Lu, Xiaocui Chen, Yuan Guo and Ju Liu
    Citation: Diagnostic Pathology 2015 10:137
    Content type: Letter to the Editor Published on:

  29. Inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) has recently been found to be implicated in the tumor progression of various cancers. However, the expression and the prognostic value of ITPKA in hepatocellular...

    Authors: Jianbiao Li, Ying-Hui Zhu, Pinzhu Huang, Baozhu Zhang, Jian Sun and Xin-Yuan Guan
    Citation: Diagnostic Pathology 2015 10:136
    Content type: Research Published on:

  30. Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, mainly due to its high rates of postoperative recurrence and metastasis. It currently ranks as the third most common cause o...

    Authors: Hossein Ajdarkosh, Masoomeh Dadpay, Emad Yahaghi, Elham Rostami Pirzaman, Amir Farshid Fayyaz, Ebrahim Khodaverdi Darian and Aram Mokarizadeh
    Citation: Diagnostic Pathology 2015 10:135
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2016 11:105

  31. Thrombotic diseases are a group of prevalent and life-threatening diseases. Selective inhibition of pathological thrombosis holds the key to treat variety of thrombotic diseases. The pathological thrombosis ca...

    Authors: Xinyu Yang, Haichao Wang, Menmen Zhang, Jin Liu, Ben Lv and Fangping Chen
    Citation: Diagnostic Pathology 2015 10:134
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:70

  32. Hypermethylation of the promoter region of the RAS association domain family 1A gene (RASSF1A) occurs widely in hepatocellular carcinoma (HCC) tissues. While the diagnostic performance of the use of RASSF1A me...

    Authors: Xueyan Dong, Hui He, Weiying Zhang, Daojun Yu, Xianjun Wang and Yueming Chen
    Citation: Diagnostic Pathology 2015 10:133
    Content type: Research Published on:

  33. According to current clinical guidelines mutational analysis for KRAS and NRAS is recommended prior to EGFR-directed therapy of colorectal cancer (CRC) in the metastatic setting. Therefore, reliable, fast, sensit...

    Authors: Mark Kriegsmann, Norbert Arens, Volker Endris, Wilko Weichert and Jörg Kriegsmann
    Citation: Diagnostic Pathology 2015 10:132
    Content type: Research Published on:

  35. Several c-MET targeting inhibitory molecules have already shown promising results in the treatment of patients with Non-small Cell Lung Cancer (NSCLC). Combination of EGFR- and c-MET-specific molecules may ove...

    Authors: I. Watermann, B. Schmitt, F. Stellmacher, J. Müller, R. Gaber, Ch. Kugler, N. Reinmuth, R. M. Huber, M. Thomas, P. Zabel, K. F. Rabe, D. Jonigk, A. Warth, E. Vollmer, M. Reck and T. Goldmann
    Citation: Diagnostic Pathology 2015 10:130
    Content type: Research Published on:

  36. Chronic hepatitis B virus (HBV) infection is a known major etiological factor for hepatocellular carcinoma (HCC) development. Alpha-fetoprotein (AFP) is widely used to detect primary HCC, whereas its sensitivi...

    Authors: Fujun Yu, Zhongqiu Lu, Bicheng Chen, Peihong Dong and Jianjian Zheng
    Citation: Diagnostic Pathology 2015 10:129
    Content type: Research Published on:

  37. Several reports indicate the high-affinity receptor of NT (neurotensin), NTR1 (neurotensin receptor 1), in numerous detrimental functions linked to neoplastic progression of several cancer types. Recently, it ...

    Authors: Zhouyi Zhou, Jiaming Xie, Ying Cai, Shudong Yang, Ying Chen and HaoRong Wu
    Citation: Diagnostic Pathology 2015 10:128
    Content type: Research Published on:

    The Erratum to this article has been published in Diagnostic Pathology 2015 10:173

  38. The microRNAs present a class of non-coding RNAs which are usually implicated in tumor biology. Recent report has unraveled that a novel member of microRNA family called miR-1246. However, the functional role ...

    Authors: Weihua Huang, Huifen Li and Rongcheng Luo
    Citation: Diagnostic Pathology 2015 10:127
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2017 12:53

  39. A recently published transcript set is suitable for gene expression-based discrimination of normal colonic and colorectal cancer (CRC) biopsy samples. Our aim was to test the discriminatory power of the CRC-sp...

    Authors: Alexandra Kalmár, Barnabás Wichmann, Orsolya Galamb, Sándor Spisák, Kinga Tóth, Katalin Leiszter, Boye Schnack Nielsen, Barbara Kinga Barták, Zsolt Tulassay and Béla Molnár
    Citation: Diagnostic Pathology 2015 10:126
    Content type: Research Published on:

  40. Cdc7 is a widely expressed protein kinase implicated in cell division, cell cycle checkpoint mechanisms and cancer progression. Recently, it has been suggested as a target for anti-cancer therapy.

    Authors: Nathaniel Melling, Johanna Muth, Ronald Simon, Carsten Bokemeyer, Luigi Terracciano, Guido Sauter, Jakob Robert Izbicki and Andreas Holger Marx
    Citation: Diagnostic Pathology 2015 10:125
    Content type: Research Published on:

  42. Malignant ameloblastoma (metastatic ameloblastoma, MA) is currently defined as a distinct pathologic entity, MA, despite its histologically benign appearance. According to the new criteria, the histological an...

    Authors: Rui Bi, Lei Shen, Xiongzeng Zhu and Xiaoli Xu
    Citation: Diagnostic Pathology 2015 10:123
    Content type: Case report Published on:

  43. Early assessment of response to chemotherapy in acute myeloid leukemia may be performed by examining bone marrow aspirate (BMA) or biopsy (BMB); a hypocellular bone marrow sample indicates adequate anti-leukem...

    Authors: João Tadeu D Souto Filho, Monique M Loureiro, Wolmar Pulcheri, José Carlos Morais, Marcio Nucci and Rodrigo D Portugal
    Citation: Diagnostic Pathology 2015 10:122
    Content type: Research Published on:

  44. The determination of NRAS and BRAF mutation status is a major requirement in the treatment of patients with metastatic melanoma. Mutation specific antibodies against NRASQ61R and BRAFV600E proteins could offer ad...

    Authors: Arnaud Uguen, Matthieu Talagas, Sebastian Costa, Laura Samaison, Laure Paule, Zarrin Alavi, Marc De Braekeleer, Cédric Le Marechal and Pascale Marcorelles
    Citation: Diagnostic Pathology 2015 10:121
    Content type: Research Published on:

  45. It is well established that macrophage infiltration is involved in concanavalin A (conA)-induced liver injury. However, the role of macrophages in conA-induced renal injury remains unknown. The aims of this st...

    Authors: Cheng Liu, Zhuoan Cheng, Yunman Wang, Xiuqin Dai, Jie Zhang and Dongying Xue
    Citation: Diagnostic Pathology 2015 10:120
    Content type: Research Published on:

  46. Pathological classification of cervical intraepithelial neoplasia (CIN) is problematic as it relies on subjective criteria. We developed an imaging method that uses spectroscopy to assess the fluorescent inten...

    Authors: Mario R. Castellanos, Anita Szerszen, Stephen Gundry, Edyta C. Pirog, Mitchell Maiman, Sritha Rajupet, John Paul Gomez, Adi Davidov, Priya Ranjan Debata, Probal Banerjee and Jimmie E. Fata
    Citation: Diagnostic Pathology 2015 10:119
    Content type: Research Published on:

  47. Tumours of ovarian-epithelial type of the testis, including serous borderline tumours, represent very rare entities. They are identical to the surface epithelial tumours of the ovary and have been reported in ...

    Authors: Tobias Bürger, Hans-Ulrich Schildhaus, Reinhard Inniger, Joachim Hansen, Peter Mayer, Stefan Schweyer, Heinz Joachim Radzun, Philipp Ströbel and Felix Bremmer
    Citation: Diagnostic Pathology 2015 10:118
    Content type: Case Report Published on:

  48. MicroRNAs (miRNAs) can serve as tumor suppressors and might provide an efficient strategy for annihilating tumor cells. Nevertheless, the potential role of miR-325 in hepatocellular carcinoma (HCC) is still un...

    Authors: Huifen Li, Weihua Huang and Rongcheng Luo
    Citation: Diagnostic Pathology 2015 10:117
    Content type: Research Published on:

    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:26

  50. Glomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein...

    Authors: Katsutoshi Hirose, Takahiro Matsui, Hiroaki Nagano, Hidetoshi Eguchi, Shigeru Marubashi, Hiroshi Wada and Eiichi Morii
    Citation: Diagnostic Pathology 2015 10:112
    Content type: Case report Published on:
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Diagnostic Pathology

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