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  1. Content type: Research

    Metastasis-associated in colon cancer 1 (MACC1) has been reported to promote tumor cell invasion and metastasis. Cancer stem cells and epithelial-mesenchymal transition (EMT) have also been reported to promote...

    Authors: Bo Zhu, Yichao Wang, Xiaolin Wang, Shiwu Wu, Lei Zhou, Xiaomeng Gong, Wenqing Song and Danna Wang

    Citation: Diagnostic Pathology 2018 13:45

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  2. Content type: Case Report

    Ovarian serous borderline tumor/atypical proliferative serous tumor (SBT/APST) is characterized by presenting at an early stage and much longer survival than high-grade serous carcinoma. Given that the prognos...

    Authors: Chiaki Kubo, Shigenori Nagata, Takeshi Fukuda, Rieko Kano, Takaaki Tanaka, Katsuyuki Nakanishi, Masahiko Ohsawa and Shin-ichi Nakatsuka

    Citation: Diagnostic Pathology 2018 13:43

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  3. Content type: Research

    The incidence of abnormal cervical smears in the United Arab Emirates (UAE) is 3.6%. Data regarding specific high-risk HPV (hrHPV) genotypes are insufficient. Identification of hrHPV subtypes is essential to a...

    Authors: Alia Albawardi, M. Ruhul Quddus, Shamsa Al Awar and Saeeda Almarzooqi

    Citation: Diagnostic Pathology 2018 13:42

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  4. Content type: Retraction Note

    The editor has retracted this article [1] because of flaws and inconsistencies in the methodology, reporting and interpretation of the data.

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao and Tao Li

    Citation: Diagnostic Pathology 2018 13:40

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    The original article was published in Diagnostic Pathology 2018 13:11

  5. Content type: Research

    The Ki-67 Labelling Index (LI) is used as an ancillary tool in glioma diagnostics. Interobserver variability has been reported and no precise guidelines are available. Nor is it known whether novel digital app...

    Authors: Ljudmilla A. G. Nielsen, Julie A. Bangsø, Kim H. Lindahl, Rikke H. Dahlrot, Jacob v. B. Hjelmborg, Steinbjørn Hansen and Bjarne W. Kristensen

    Citation: Diagnostic Pathology 2018 13:38

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  6. Content type: Case Report

    Lymphoepithelioma-like carcinoma (LELC) is a rare entity among thyroid tumors. Based on the limited number of case reports that exist, the association of Epstein–Barr virus (EBV) with primary thyroid LELCs see...

    Authors: Chih-Yi Liu and Shih-Hung Huang

    Citation: Diagnostic Pathology 2018 13:39

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  7. Content type: Case Report

    Primary central nervous system lymphoma (PCNSL) is an uncommon tumor in the brain. Although most PCNSL are readily diagnosed as diffuse large B cell lymphoma (DLBCL) on the first biopsy, very rare cases have b...

    Authors: Rodrigo Javier, Nawal Shaikh, Maciej S. Lesniak, Adam Sonabend, Roger Stupp, Amir Behdad and Craig Horbinski

    Citation: Diagnostic Pathology 2018 13:37

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  8. Content type: Research

    Nuclear forkhead box protein P1 (N-FOXP1) expression in invasive breast cancer has been documented in the literature. However, the FOXP1 expression patterns at different stages of breast cancer progression are...

    Authors: Bao-Hua Yu, Bai-Zhou Li, Xiao-Yan Zhou, Da-Ren Shi and Wen-Tao Yang

    Citation: Diagnostic Pathology 2018 13:36

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  9. Content type: Research

    The mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease resulting from the defective activity of the enzyme α-L-iduronidase (IDUA). The disease has three major clinical subtypes (severe Hurler syn...

    Authors: Latifa Chkioua, Hela Boudabous, Ibtissem Jaballi, Oussama Grissa, Hadhami Ben Turkia, Neji Tebib and Sandrine Laradi

    Citation: Diagnostic Pathology 2018 13:35

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  10. Content type: Research

    Radiotherapy is one of the most common and effective treatment methods for cancer, and improving the radiosensitivity of tumor tissues during the treatment process is vital. We report the mechanisms of glycoge...

    Authors: Jialin Ren, Tingting Liu, Yang Han, Qiongzi Wang, Yanzhi Chen, Guang Li and Lihong Jiang

    Citation: Diagnostic Pathology 2018 13:33

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  11. Content type: Case Report

    We report the first case of composite lymphoma consisting of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL) and high-grade B-cell lymphoma with MYC and BCL2 rearrangem...

    Authors: Alison M. Moore, Olga Moshkin, Gordon J. Swain, Susan Crocker and David P. LeBrun

    Citation: Diagnostic Pathology 2018 13:34

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  12. Content type: Research

    Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections.

    Authors: Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao and Zhe Wang

    Citation: Diagnostic Pathology 2018 13:31

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  13. Content type: Research

    Recent research supports a significant role of immune checkpoint inhibitors in the treatment of solid tumors. However, relevant reports for programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphoc...

    Authors: Haiyue Wang, Zhongwu Li, Bin Dong, Wei Sun, Xin Yang, Ruping Liu, Lixin Zhou, Xiaozheng Huang, Ling Jia and Dongmei Lin

    Citation: Diagnostic Pathology 2018 13:30

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  14. Content type: Case Report

    The occurrence of malignant lymphoma after delivery is an extremely rare event. Although several cases of Hodgkin lymphoma and B cell lymphoma and a few cases of peripheral T cell lymphoma (PTCL) after deliver...

    Authors: Kenichi Mizutani, Sohsuke Yamada, Xin Guo, Chizuru Futatsuya, Motona Kumagai, Akihiro Shioya, Akane Aikawa, Satoko Nakada, Nozomu Kurose, Hiroshi Minato and Takayuki Nojima

    Citation: Diagnostic Pathology 2018 13:32

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  15. Content type: Research

    Telepathology (TP) provides remote pathology services for primary diagnosis practices, including intraoperative consultation of surgical pathology; it has not been widely implemented in China. In this study, t...

    Authors: Yingxin Huang, Yan Lei, Qi Wang, Dazhou Li, Lili Ma, Lili Guo, Minshan Tang, Guanglong Liu, Qianwen Yan, Lan Shen, Guihui Tong, Zhiliang Jing, Yan Zhang and Yongjian Deng

    Citation: Diagnostic Pathology 2018 13:29

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  16. Content type: Case Report

    Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK pro...

    Authors: Ryuko Nakayama, Yuki Togashi, Satoko Baba, Yo Kaku, Yuki Teramoto, Takaki Sakurai, Hironori Haga and Kengo Takeuchi

    Citation: Diagnostic Pathology 2018 13:28

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  17. Content type: Case Report

    The diagnosis of granulomatous amoebic encephalitis is challenging for clinicians because it is a rare and lethal disease. Previous reports have indicated that Acanthamoeba with some specific genotypes tend to ca...

    Authors: Takahiro Matsui, Tetsuo Maeda, Shinsuke Kusakabe, Hideyuki Arita, Kenji Yagita, Eiichi Morii and Yuzuru Kanakura

    Citation: Diagnostic Pathology 2018 13:27

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  18. Content type: Research

    The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85–90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phen...

    Authors: Perikles Kosmidis, Barbara Mankel, Falko Fend and Patrick Adam

    Citation: Diagnostic Pathology 2018 13:25

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  19. Content type: Retraction Note

    The editor has retracted this article [1] because it shows significant overlap with the following articles (amongst others) [2, 3]. None of the authors responded to correspondence regarding this retraction.

    Authors: Huifen Li, Weihua Huang and Rongcheng Luo

    Citation: Diagnostic Pathology 2018 13:26

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    The original article was published in Diagnostic Pathology 2015 10:117

  20. Content type: Case Report

    Although p53 signature, benign-appearing epithelial cells with p53 diffuse expression, is frequently found in the fallopian tubes, the clinical and pathological significance of this lesion in the case of high-...

    Authors: Yuichiro Hatano, Shinya Fukuda, Hiroshi Makino, Hiroyuki Tomita, Ken-ichirou Morishige and Akira Hara

    Citation: Diagnostic Pathology 2018 13:24

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  21. Content type: Research

    Hepatic steatosis renders hepatocytes vulnerable to injury, resulting in the progression of preexisting liver disease. Previous animal and cell culture studies implicated mammalian target of rapamycin (mTOR), ...

    Authors: Euno Choi, Won Kim, Sae Kyung Joo, Sunyoung Park, Jeong Hwan Park, Yun Kyung Kang, So-Young Jin and Mee Soo Chang

    Citation: Diagnostic Pathology 2018 13:23

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  22. Content type: Research

    The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 i...

    Authors: Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang and Weibiao Cao

    Citation: Diagnostic Pathology 2018 13:22

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  23. Content type: Research

    Tumour budding (TB) and Tumour Stroma Ratio (TSR) may be rewarding in the treatment stratification of patients with stage II colon cancer. However, lack of standardization may exclude these parameters from bei...

    Authors: Ann C. Eriksen, Johnnie B. Andersen, Jan Lindebjerg, René dePont Christensen, Torben F. Hansen, Sanne Kjær-Frifeldt and Flemming B. Sørensen

    Citation: Diagnostic Pathology 2018 13:20

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  24. Content type: Research

    Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. Immunohistochemistry (IHC) of the HER2 protein is the mo...

    Authors: Andreas H. Scheel, Frédérique Penault-Llorca, Wedad Hanna, Gustavo Baretton, Peter Middel, Judith Burchhardt, Manfred Hofmann, Bharat Jasani and Josef Rüschoff

    Citation: Diagnostic Pathology 2018 13:19

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  25. Content type: Case Report

    Ischemic fasciitis is a distinctive pseudosarcomatous entity with a marked predilection for elderly and physically debilitated or immobilized patients. The etiology of these lesions is unknown but felt to be r...

    Authors: Taha Sachak, Nyla A. Heerema, Joel Mayerson, Jason E. Payne, Anil Parwani and O. Hans Iwenofu

    Citation: Diagnostic Pathology 2018 13:18

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  26. Content type: Research

    The clinicopathological features and Epstein-Barr virus (EBV) infection status of lymphoma in children and adolescents in South China is under-researched. South China is a well-known high-incidence area of EBV...

    Authors: Changfei Qin, Yuhua Huang, Yanfen Feng, Min Li, Na Guo and Huilan Rao

    Citation: Diagnostic Pathology 2018 13:17

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  27. Content type: Case Report

    Plasma cell myeloma (PCM) is a neoplasm of terminally differentiated B lymphocytes with molecular heterogeneity. Although therapy-related myeloid neoplasms are common in plasma cell myeloma patients after chem...

    Authors: Jonathon H. Gralewski, Ginell R. Post, Frits van Rhee and Youzhong Yuan

    Citation: Diagnostic Pathology 2018 13:15

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  28. Content type: Case Report

    Mast cell leukemia (MCL) is a very rare form of systemic mastocytosis (SM) and accounts for less than 0.5% of all mastocytosis. The diagnosis of MCL requires the presence of SM criteria, accompanied by leukemi...

    Authors: Yalin Zheng, Lin Nong, Li Liang, Wei Wang and Ting Li

    Citation: Diagnostic Pathology 2018 13:14

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  29. Content type: Research

    The DecisionDx-Melanoma test provides prognostic information for patients with cutaneous melanoma (CM). Using formalin-fixed paraffin-embedded primary tumor tissue, the RT-PCR-based test classifies patients in...

    Authors: Robert W. Cook, Brooke Middlebrook, Jeff Wilkinson, Kyle R. Covington, Kristen Oelschlager, Federico A. Monzon and John F. Stone

    Citation: Diagnostic Pathology 2018 13:13

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  30. Content type: Review

    The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer ty...

    Authors: Margarita Udall, Maria Rizzo, Juliet Kenny, Jim Doherty, SueAnn Dahm, Paul Robbins and Eric Faulkner

    Citation: Diagnostic Pathology 2018 13:12

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  31. Content type: Research

    Several studies have suggested that claudin proteins, which are the main components of tight junction structures, are related to the regulation of cell polarity and cell differentiation.

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li, Yunpeng Liu, Peiqing Zhao and Tao Li

    Citation: Diagnostic Pathology 2018 13:11

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    The Retraction Note to this article has been published in Diagnostic Pathology 2018 13:40

  32. Content type: Case Report

    Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as a provisional entity by the World Health Organization. Although increasing data have been publis...

    Authors: Ricardo Garcia Pastorello, Felipe D’Almeida Costa, Cynthia A. B. T. Osório, Fabiana B. A. Makdissi, Stephania Martins Bezerra, Marina de Brot, Antonio Hugo J. F. M. Campos, Fernando Augusto Soares and José Vassallo

    Citation: Diagnostic Pathology 2018 13:10

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  33. Content type: Research

    Nephroblastoma or Wilms tumor is the most frequent kidney cancer in children and accounts for 98% of kidney tumors in this age group. Despite favorable prognosis, a subgroup of these patients progresses to rec...

    Authors: Ana Paula Percicote, Gabriel Lazaretti Mardegan, Elizabeth Schneider Gugelmim, Sergio Ossamu Ioshii, Ana Paula Kuczynski, Seigo Nagashima and Lúcia de Noronha

    Citation: Diagnostic Pathology 2018 13:9

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  34. Content type: Research

    Human intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by...

    Authors: Rondell P. Graham, Bita V. Naini, Sejal S. Shah, Christina A. Arnold, Rajesh Kannangai, Michael S. Torbenson and Dora M. Lam-Himlin

    Citation: Diagnostic Pathology 2018 13:7

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  35. Content type: Research

    Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The pre...

    Authors: Xiaolong Liang, Jian Sun, Huanwen Wu, Yufeng Luo, Lili Wang, Junliang Lu, Zhiwen Zhang, Junchao Guo, Zhiyong Liang and Tonghua Liu

    Citation: Diagnostic Pathology 2018 13:5

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  36. Content type: Case Report

    IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary t...

    Authors: Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine and Kenzo Hiroshima

    Citation: Diagnostic Pathology 2018 13:6

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  37. Content type: Research

    Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tum...

    Authors: Eleonora Bonaparte, Chiara Pesenti, Laura Fontana, Rossella Falcone, Leda Paganini, Anna Marzorati, Stefano Ferrero, Mario Nosotti, Paolo Mendogni, Claudia Bareggi, Silvia Maria Sirchia, Silvia Tabano, Silvano Bosari and Monica Miozzo

    Citation: Diagnostic Pathology 2018 13:4

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  38. Content type: Case Report

    A proper balance between the activator and the repressor form of GLI3, a zinc-finger transcription factor downstream of hedgehog signaling, is essential for proper development of various organs during developm...

    Authors: Saki Ito, Riko Kitazawa, Ryuma Haraguchi, Takeshi Kondo, Ayaka Ouchi, Yasuo Ueda and Sohei Kitazawa

    Citation: Diagnostic Pathology 2018 13:1

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  39. Content type: Research

    Extra-mammary Paget’s disease of the vulva (EMPDV) is an infrequent chronic disease that often recurs. The aim of the study was to assess the presence of neoangiogenesis and the expression of epithelial-mesenc...

    Authors: Lara Alessandrini, Nicolò Clemente, Tiziana Perin, Giorgio Giorda, Vincenzo Canzonieri and Francesco Sopracordevole

    Citation: Diagnostic Pathology 2018 13:2

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  40. Content type: Research

    The nucleolus is an organelle that is an ultrastructural element of the cell nucleus observed in H&E staining as a roundish body stained with eosin due to its high protein content. Changes in the nucleoli cyto...

    Authors: Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Adam Maciejczyk and Rafal Matkowski

    Citation: Diagnostic Pathology 2017 12:88

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  41. Content type: Research

    Mounting evidence has shown that KRAS and BRAF are somatic mutations associated with low grade serous carcinoma (LGSC) of the ovary. However, the frequency of KRAS or BRAF mutation was variable in literatures,...

    Authors: Yan Xu, Rui Bi, Yaoxing Xiao, Xiaoyu Tu, Ming Li, Anqi Li, Ling Shan, Shuling Zhou and Wentao Yang

    Citation: Diagnostic Pathology 2017 12:87

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  42. Content type: Case Report

    Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive an...

    Authors: Jing Xiong, Tiefen Su, Pengcheng Zhu, Qilin Ao, Qiurong Ruan and Guoping Wang

    Citation: Diagnostic Pathology 2017 12:86

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  43. Content type: Case Report

    Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) G...

    Authors: Hiromi Kanno-Okada, Tomoko Mitsuhashi, Katsuhiro Mabe, Tadakazu Shimoda and Yoshihiro Matsuno

    Citation: Diagnostic Pathology 2017 12:85

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  44. Content type: Research

    Hematoxylin-eosin (HE) staining of a full-thickness rectal wall fragment is classically used for the diagnosis of Hirschsprung disease (HD). However, this technique requires large fragments for a better diagno...

    Authors: Suellen Serafini, Maria Mercês Santos, Ana Cristina Aoun Tannuri, Maria Claudia Nogueira Zerbini, Maria Cecília de Mendonça Coelho, Josiane de Oliveira Gonçalves and Uenis Tannuri

    Citation: Diagnostic Pathology 2017 12:84

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  45. Content type: Case Report

    Plasmablastic lymphoma (PBL) is relatively new clinical entity described as a distinct subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by its aggressive nature and proliferation of large ...

    Authors: Ita Hadžisejdić, Emina Babarović, Luka Vranić, Antica Duletić Načinović, Ksenija Lučin, Maja Krašević and Nives Jonjić

    Citation: Diagnostic Pathology 2017 12:83

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