Articles

Diagnostic value of miR-186-5p for carotid artery stenosis and its predictive significance for future cerebral ischemic event

MicroRNAs (miRNAs) serve as novel promising biomarkers for the diagnosis and prognosis of many human diseases. This study investigated the diagnostic value of miR-186-5p for asymptomatic carotid artery stenosi...

Authors: Weibo Lv, Tao Zhang, Hongwei Zhao, Shuang He, Bingwei Li, Yang Gao and Wenying Pan

Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images

Multiplex immunohistochemistry (mIHC) permits the labeling of six or more distinct cell types within a single histologic tissue section. The classification of each cell type requires detection of uniquely colo...

Authors: Danielle J. Fassler, Shahira Abousamra, Rajarsi Gupta, Chao Chen, Maozheng Zhao, David Paredes, Syeda Areeha Batool, Beatrice S. Knudsen, Luisa Escobar-Hoyos, Kenneth R. Shroyer, Dimitris Samaras, Tahsin Kurc and Joel Saltz

The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases

Molecular diagnostics can be decisive in the differential diagnosis between a somatic metastasis of type II testicular germ cell tumor (TGCT) or a second primary carcinoma. This is in line with recent recommen...

Authors: Mariëtte E. G. Kranendonk, Wenzel M. Hackeng, G. Johan A. Offerhaus, Folkert H. M. Morsink, Geertruida N. Jonges, Gerard Groenewegen, Pieter-Jaap Krijtenburg, Heinz-Josef Klümpen, Wendy W. J. de Leng, Leendert H. J. Looijenga and Lodewijk A. A. Brosens

Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway

Fibro-adipose vascular anomaly (FAVA) is a new entity of vascular anomalies with somatic and mosaic gain-of-function mutations of the phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3C...

Authors: Yumiko Hori, Katsutoshi Hirose, Noriko Aramaki-Hattori, Sachi Suzuki, Robert Nakayama, Masanori Inoue, Takahiro Matsui, Masaharu Kohara, Satoru Toyosawa and Eiichi Morii

Malakoplakia of the gastrointestinal tract: clinicopathologic analysis of 23 cases

Malakoplakia is an uncommon, tumor-like inflammatory disease characterized by impaired histiocytes that are unable to completely digest phagocytized bacteria. The genitourinary tract is the most common site of...

Authors: Michael Lee, Huaibin Mabel Ko, Anthony Rubino, Hwajeong Lee, Ryan Gill and Stephen M. Lagana

miR-541 serves as a prognostic biomarker of osteosarcoma and its regulatory effect on tumor cell proliferation, migration and invasion by targeting TGIF2

Several studies reported the dysregulation of miR-541 in the progression of some human malignancies. Osteosarcoma (OS) is one of the most common primary malignant bone tumors. This study aimed to assess the ex...

Authors: Chunlei Liu and Xiuling Yi

Desmoplastic small round cell tumor of the kidney: a case report

Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive neoplasm seen in children and young adults, usually manifested by involvement of abdominal serosa. Here, we present an unusual case of primary ...

Authors: Dilek Ertoy Baydar, Ayse Armutlu, Oguz Aydin, Ayhan Dagdemir and Yarkin Kamil Yakupoglu

SLC14A1 (UT-B) gene rearrangement in urothelial carcinoma of the bladder: a case report

Bladder cancer (BC) is a common and deadly disease. Over the past decade, a number of genetic alterations have been reported in BC. Bladder urothelium expresses abundant urea transporter UT-B encoded by Slc14a1 g...

Authors: Zhongying Guo, Xiaobing Niu, Guangbo Fu, Baoxue Yang, Guangping Chen and Su’an Sun

46, XY disorder of sex development (DSD) complicated by a serous borderline tumor of the ovary: a case report and review of the literature

Patients with 46, XY disorder of sex development (DSD) are predisposed to the development of gonadal tumors, particularly germ cell tumors and gonadoblastoma. However, to the best of our knowledge, there are n...

Authors: Jiangying Zhao, Jiao Peng, Sisi He, Jia Yang and Xiaojun Pang

Peritumoral/vascular expression of PSMA as a diagnostic marker in hepatic lesions

The differential diagnosis between primary cholangiocarcinoma and metastatic pancreatobiliary adenocarcinoma is histologically challenging due to lack of distinct morphological features and reliable molecular ...

Authors: Wei Chen, Zhenghong Lee, Amad Awadallah, Lan Zhou and Wei Xin

Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis

Mesonephric-like adenocarcinoma (M-LAC) is a rare, recently described tumor occurring in the uterine corpus and ovary, which shares the same morphological and immunohistochemical features with the more common ...

Authors: Pavel Dundr, Mária Gregová, Kristýna Němejcová, Michaela Bártů, Nikola Hájková, Jan Hojný, Ivana Stružinská and Daniela Fischerová

Serious takotsubo cardiomyopathy: an autopsy case presenting severe irreversible myocardial damage after frequent episodes of recurrence

Takotsubo cardiomyopathy is characterized by transient dysfunction of the medial to apical segment of the left ventricle. Recurrence within a few months or years has been reported and serious complications, in...

Authors: Kenichi Mizutani, Akihiro Shioya, Yasuyo Hirose, Ryuhei Saito and Sohsuke Yamada

Anaplastic thyroid carcinoma with chondrosarcomatous differentiation: a case report

Anaplastic thyroid carcinoma (ATC) is a rare malignant tumor. In addition to the main ATC type with classical histopathological features, the other morphological types of ATC include paucicellular variant, ang...

Authors: Jixuan Liu, Ni Cui, Wenjia Ding, Xinjie Dong, Xiaoshuai Chen, Jun Jiang and Yafang Liu

Unexpected endometrial malacoplakia related to abortion and placental rests retention: a case report

Malacoplakia is a rare chronic inflammatory disease. The name derives from the Greek “μαλακός” meaning “soft” and “πλάξ” meaning “plaque”, describing its usual macroscopic presentation as a friable yellow soft pl...

Authors: Antonio d’Amati, Emilio Bellitti and Leonardo Resta

Semantic segmentation to identify bladder layers from H&E Images

Identification of bladder layers is a necessary prerequisite to bladder cancer diagnosis and prognosis. We present a method of multi-class image segmentation, which recognizes urothelium, lamina propria, muscu...

Authors: Muhammad Khalid Khan Niazi, Enes Yazgan, Thomas E. Tavolara, Wencheng Li, Cheryl T. Lee, Anil Parwani and Metin N. Gurcan

Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America

Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be cha...

Authors: Peter F. Rambau, Martin Köbel, Derek Tilley, Alex Mremi, Robert Lukande and William Muller

The spectrum of pathological findings in coronavirus disease (COVID-19) and the pathogenesis of SARS-CoV-2

Authors: Rolf F. Barth, L. Maximillian Buja and Anil V. Parwani

Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with in...

Authors: Esther Moreno, Juan M. Rosa-Rosa, Tamara Caniego-Casas, Ignacio Ruz-Caracuel, Cristian Perna, Carmen Guillén and José Palacios

Deadly combination of E-cigarettes has become a popular-lnduced lung injury and Influenza: case report

E-cigarette and vaping use-associated acute lung injury (EVALI) has been recently recognized as a complication in individuals who use vaping devices. Another consideration is that EVALI may have an adverse inf...

Authors: Bindu H. Akkanti, Rahat Hussain, Manish K. Patel, Jayeshkumar A. Patel, Kha Dinh, Bihong Zhao, Shaimaa Elzamly, Kevin Pelicon, Klemen Petek, Ismael A. Salas de Armas, Mehmet Akay, Biswajit Kar, Igor D. Gregoric and L. Maximilian Buja

Density and size of lymphoid follicles are useful clues in differentiating primary intestinal follicular lymphoma from intestinal reactive lymphoid hyperplasia

Primary intestinal follicular lymphoma (PI-FL) is a rare and indolent lymphoma and is challenging for diagnosis with endoscopic biopsy specimens. Whole slide imaging (WSI) has been increasingly used for assist...

Authors: Hsin-Ni Li, Ren Ching Wang, Jun-Peng Chen, Sheng-Tsung Chang and Shih-Sung Chuang

Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases

Pathologists frequently encounter neuroendocrine tumors (NETs) presenting as multiple liver masses in routine practice. Most often, these are well-differentiated tumors with characteristic histologic features....

Authors: Elise R. Venable, Sarah E. Kerr, M. Beatriz S. Lopes, Karra A. Jones, Andrew M. Bellizzi, Taofic Mounajjed, Aditya Raghunathan, Oksana Hamidi, Thorvardur R. Halfdanarson, Mabel Ryder and Rondell P. Graham

Accuracy and efficiency of an artificial intelligence tool when counting breast mitoses

The mitotic count in breast carcinoma is an important prognostic marker. Unfortunately substantial inter- and intra-laboratory variation exists when pathologists manually count mitotic figures. Artificial inte...

Authors: Liron Pantanowitz, Douglas Hartman, Yan Qi, Eun Yoon Cho, Beomseok Suh, Kyunghyun Paeng, Rajiv Dhir, Pamela Michelow, Scott Hazelhurst, Sang Yong Song and Soo Youn Cho

Histopathological findings for prediction of liver cirrhosis and survival in biliary atresia patients after Kasai procedure

Without early recognition and Kasai procedure, biliary atresia (BA) results in liver cirrhosis and leads to either transplantation or death at a young age. We aimed to characterize the liver histopathological ...

Authors: Gunadi, Dian Nirmala Sirait, Leila Rakhma Budiarti, Vincentia Meta Widya Paramita, Aditya Rifqi Fauzi, Fiko Ryantono, Dwiki Afandy, Naomi Yoshuantari, Hanggoro Tri Rinonce and Akhmad Makhmudi

The impact of COVID-19 on ischemic stroke

The outbreak of a novel coronavirus since December 2019, became an emergency of major international concern. As of June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 ...

Authors: Pan Zhai, Yanbing Ding and Yiming Li

Investigation of Atyp.C using UF-5000 flow cytometer in patients with a suspected diagnosis of urothelial carcinoma: a single-center study

This study evaluated the predictive power of Atyp.C (a parameter of UF-5000 flow cytometer) for patients with a suspected diagnosis of urothelial carcinoma.

Authors: Chunyun Ren, Xing Wang, Chunwei Yang, Shengchao Li, Shuangchun Liu and Hongcui Cao

A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast

Myofibroblastoma (MFB) and low-grade adenosquamous carcinoma (LGASC) are rare tumours in the breast, respectively. However, a collision tumour of the two types has never been reported.

Authors: Guang-Zhi Yang, Shang-Hua Liang and Xiao-Hong Shi

Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors

We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopatholo...

Authors: Yuri Akishima-Fukasawa, Naoko Honma, Hideaki Ogata, Yoshikiyo Akasaka and Tetuo Mikami

Diagnostic value of miR-92a in asymptomatic carotid artery stenosis patients and its ability to predict cerebrovascular events

Early diagnosis of asymptomatic carotid artery stenosis (ACAS) is important to prevent the incidence of cerebrovascular events. This study aimed to investigate the circulating expression of microRNA-92a (miR-9...

Authors: Gang Chen, Jianwei Gao, Yuguo Sheng, Xinqiang Han, Xingang Ji, Mengpeng Zhao and Jian Wu

Histopathology of COVID-19 pneumonia in two non-oncological, non-hospitalised cases as a reliable diagnostic benchmark

In lung cancer patients infected with COVID-19, pathological features are not easy to distinguish. This report presents detailed histopathological findings in two non-neoplastic subjects whose out-of-hospital ...

Authors: Roberto Scendoni, Francesca Marchesani, Nunzia Cannovo, Piergiorgio Fedeli and Mariano Cingolani

EBV-positive intravascular large B-cell lymphoma of the liver: a case report and literature review

Intravascular large B-cell lymphoma (IVLBCL) is an extremely rare subtype of diffuse large B-cell lymphoma that most commonly involves the central nervous system, skin, and bone marrow. To our knowledge, Epste...

Authors: Qingjiao Li, Jinghe Li, Keda Yang, Ying Peng, Yao Xiang, Shuyuan Sun, Jian Zeng, Xin Zhang and Junpu Wang

A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion

Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted thera...

Authors: Xiaohong Xie, Xinqing Lin, Ming Liu, Yinyin Qin, Ming Ouyang, Shiyue Li, Yingying Gu, Shuyin Chen, Jianxing Xiang and Chengzhi Zhou

Neuroprotective effects of miR-142-5p downregulation against isoflurane-induced neurological impairment

Isoflurane can lead to neuron damage to the developing brain, resulting in learning and memory disability. The aim of this study was to investigate the role of miR-142-5p on isoflurane-induced neurological imp...

Authors: Cuili Xie, Hongyue Wang, Yu Zhang and Yanhua Wei

Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas

The prognostic potential of PD-L1 is currently unclear in gastric carcinomas, although the immune checkpoint PD-1/PD-L1 inhibitors have produced promising results in clinical trials.

Authors: Euno Choi, Mee Soo Chang, Sun-ju Byeon, Heejin Jin, Kyeong Cheon Jung, Haeryoung Kim, Kook Lae Lee, Won Kim, Jin Hyun Park, Ki Hwan Kim, Jin-Soo Kim, In Sil Choi, Dong-Seok Han, Hye Seong Ahn and Seung Chul Heo

Yolk sac tumor differentiation in urothelial carcinoma of the urinary bladder: a case report and differential diagnosis

Yolk sac tumor (YST) is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These latter cases have been documented in several or...

Authors: Nadia Espejo-Herrera and Enric Condom-Mundó

Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy

High Programmed death ligand 1 (PD-L1) expression are thought to be necessary to PD-1/PD-L1 axis blockades in many tumors. The aim of the study was to explore the variation of PD-L1 expression after neoadjuvan...

Authors: Yun Liang, Minghua Yu, Caiyun Zhou and Xiaojun Zhu

Targeted-gene sequencing of an undifferentiated gallbladder carcinoma: a case report

Undifferentiated carcinomas of the gallbladder are extremely rare. Most undifferentiated carcinomas are accompanied by adjacent foci of other conventional carcinomas, and a transition zone is shared between th...

Authors: Ying Xiao, Canhong Xiang, Di Yang, Benqi Zhao, Yong Li and Hongfang Yin

Automated quantitative analysis of Ki-67 staining and HE images recognition and registration based on whole tissue sections in breast carcinoma

The scoring of Ki-67 is highly relevant for the diagnosis, classification, prognosis, and treatment in breast invasive ductal carcinoma (IDC). Traditional scoring method of Ki-67 staining followed by manual co...

Authors: Min Feng, Yang Deng, Libo Yang, Qiuyang Jing, Zhang Zhang, Lian Xu, Xiaoxia Wei, Yanyan Zhou, Diwei Wu, Fei Xiang, Yizhe Wang, Ji Bao and Hong Bu

Genetic profiling of patients with adenoid cystic carcinoma of the Bartholin’s glands reveals potential new routes for targeted therapies: a case report

Bartholin gland carcinomas (BGCs) are rare tumor types, for which no molecular analyses including genomic sequencing have been reported to date. Adenoid cystic carcinomas (ACCs) of the Bartholin’s glands are a...

Authors: Kohei Nakamura, Eriko Aimono, Shigeki Tanishima, Hidetaka Nomura, Mitsuho Imai, Hideyuki Hayashi and Hiroshi Nishihara

Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma

Recently, FAM83H was reported to have roles in cancer progression in conjunction with oncogenic molecules such as MYC and b-catenin. Moreover, the data from the public database indicates a molecular relationsh...

Authors: Sung Woo Ahn, Ae-Ri Ahn, Sang Hoon Ha, Usama Khamis Hussein, Jae Do Yang, Kyoung Min Kim, Ho Sung Park, See-Hyoung Park, Hee Chul Yu and Kyu Yun Jang

Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study

Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it is increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially in Europe....

Authors: Elodie Miquelestorena-Standley, Charlotte Jaulerry, Marie-Christine Machet, Nolwenn Rabot, Christelle Barbet, Aurélie Hummel, Alexandre Karras, Cyril Garrouste, Thomas Crepin, Didier Ducloux, Maud Cousin, Catherine Albert, Joseph Rivalan, Emilie Cornec-Le Gall, François Pourreau, Clément Deltombe…

CK20 versus AMACR and p53 immunostains in evaluation of Urothelial Carcinoma in Situ and Reactive Atypia

Ancillary testing with immunohistochemistry has shown recent promise in the workup of equivocal bladder lesions. We read with interest the recent findings of Alston et al., who assessed the diagnostic utility ...

Authors: Daniel J. Neal, Mahul B. Amin and Steven C. Smith

Gli1 regulates stemness characteristics in gastric adenocarcinoma

Glioma-associated oncogene homolog 1 (Gli1), affects the progression and the stemness characteristics of malignant carcinoma. The aim of the present study was to identify the relation between Glioma-associated...

Authors: Wenbo Qi, Zhaoting Yang, Ying Feng, Haoyue Li, Nan Che, Lan Liu and Yanhua Xuan

Analysis of lung biopsies using the 2015 WHO criteria and detection of sensitizing mutations——a single-institution experience of 5032 cases

A specialized classification for small biopsies was added to the 2015 WHO classification of lung tumors. The purpose of this study is to explore and summarize the experience of applying the newly proposed clas...

Authors: Yupeng Zeng, Yunxiang Zhu, Ying Ding, Liuyang Xu, Boya Zhai, Xiang Zhang, Qiaoyun Ge, Jiao Li, Qiyuan Song, Xiao Li and Zhihong Zhang

ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto’s thyroiditis: report of a rare case and a literature review

Inflammatory myofibroblastic tumors (IMTs) of the thyroid are extremely rare soft-tissue tumors. In the literature, IMTs are sometimes called plasma cell granulomas (PCGs) or inflammatory pseudotumors, which o...

Authors: Cheng-fang Li, Xing-long Wu, Jin-jing Wang, Kai Wang, Su-yuan Zhang, Jia-jia Huang, Han-zhong Hu and Hong Zheng

Comparison of skin biopsy sample processing and storage methods on high dimensional immune gene expression using the Nanostring nCounter system

Digital multiplex gene expression profiling is overcoming the limitations of many tissue-processing and RNA extraction techniques for the reproducible and quantitative molecular classification of disease. We a...

Authors: Jelena Vider, Andrew Croaker, Amanda J. Cox, Emma Raymond, Rebecca Rogers, Stuart Adamson, Michael Doyle, Blake O’Brien, Allan W. Cripps and Nicholas P. West

Clinicopathologic characteristics, diagnostic clues, and prognoses of patients with multiple sporadic gastrointestinal stromal tumors: a case series and review of the literature

Most sporadic gastrointestinal stromal tumors (GISTs) occur as solitary tumors, while multiple sporadic GISTs are extremely rare and often misdiagnosed as metastatic GISTs, leading to inappropriate treatment. ...

Authors: Yan-Ying Shen, Xin-Li Ma, Lin-Xi Yang, Wen-Yi Zhao, Lin Tu, Chun Zhuang, Bo Ni, Qiang Liu, Ming Wang and Hui Cao

Circular RNA KIF4A promotes cell migration, invasion and inhibits apoptosis through miR-152/ZEB1 axis in breast cancer

Circular RNAs (circRNAs) have been demonstrated to exert crucial mediators in tumor initiation and development. Nevertheless, the roles of circKIF4A in breast cancer (BC) are still not very clear.

Authors: Yongping Jin, Liu Yang, Xia Li and Fangli Liu

Dysregulation of miR-3607 predicts prognosis of hepatocellular carcinoma and regulates tumor cell proliferation, migration and invasion

Hepatocellular carcinoma (HCC) is one of the most common global malignancies with increasing morbidity and mortality. The purpose of this study was to investigate the expression levels and prognostic value of ...

Authors: Wenwen Dou, Min Yang, Yan Su and Ruizhu Xie

Chondromesenchymal hamartomas in a 24-year-old male mimicking a posterior mediastinal tumor and a 5-month-old boy with postoperative disseminated intravascular coagulation: two case reports

Chondromesenchymal hamartoma of the chest wall is a rare, benign disease that usually presents at birth or in early infancy. It typically involves one or more ribs, forming a unilateral or bilateral extrapleur...

Authors: Yue Li, Danyang Zheng, Min Zuo, Yang Li and Huizhong Zhang

Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

Acral and cutaneous melanomas are usually difficult to accurately diagnose in the early stage, owing to the similarity in clinical manifestations and morphology with those of dysplastic nevus (DN). In this stu...

Authors: Yumei Lai, Yan Wu, Ruping Liu, Aiping Lu, Lixin Zhou, Lin Jia, Xinting Diao and Zhongwu Li