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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. According to 2018 ASCO/CAP guideline, HER2 FISH-equivocal breast cancers will be categorized as HER2 negative except those with IHC 3+. However, whether or not HER2 FISH-equivocal breast cancers was a heteroge...

    Authors: Hui Kong, Qianming Bai, Anqi Li, Xiaoyan Zhou and Wentao Yang
    Citation: Diagnostic Pathology 2022 17:5
    Content type: Research Published on:

  2. NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months a...

    Authors: Jin Jiang, Yikun Ren, Chengping Xu and Xing Lin
    Citation: Diagnostic Pathology 2022 17:4
    Content type: Case Report Published on:

  3. Immunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these g...

    Authors: Mohammad Hossein Anbardar, Neda Soleimani, Dornaz Safavi, Ahad Eshraghian and Abbas Ayoub
    Citation: Diagnostic Pathology 2022 17:3
    Content type: Case Report Published on:

  4. Synaptophysin (SYN), chromogranin A (CGA), CD56 and insulinoma-associated protein 1 (INSM1) are proposed neuroendocrine (NE) markers used for diagnosis of pulmonary NE tumors. These NE markers have been identi...

    Authors: Lu Yu, Yuting Dong, Jin Xue, Sanpeng Xu, Guoping Wang, Dong Kuang and Yaqi Duan
    Citation: Diagnostic Pathology 2022 17:2
    Content type: Research Published on:

  6. Pseudomyxoma peritonei (PMP) is a complex and partially understood disease defined by mucin deposits in the peritoneal cavity, mostly of appendiceal origin caused by the rupture of a mucocele often containing ...

    Authors: Marie Csanyi-Bastien, France Blanchard, Aude Lamy and Jean-Christophe Sabourin
    Citation: Diagnostic Pathology 2021 16:119
    Content type: Case Report Published on:

  7. Transmission of malignancy is a notable problem that cannot always be absolutely predicted at the time of transplantation. In particular, donor-derived transmission of synovial sarcoma in solid-organ transplan...

    Authors: Jian Zhang, Yang Yang, Ye Tian, Ruifang Xu and Jun Lin
    Citation: Diagnostic Pathology 2021 16:118
    Content type: Case Report Published on:

  8. Pancreatic medullary carcinoma (PMC) is a rare pancreatic tumor, usually showing the presence of microsatellite instability, mostly MLH1 silencing, and a wild-type KRAS mutation status. We report here a PMC ar...

    Authors: Camille Verocq, Marie-Lucie Racu, Dominique Bafort, Gloria Butorano, Luis Perez-Casanova Garcia, Julie Navez, Marc Witterwulghe, Kieran Sheahan, Niall Swan, Jean Closset, Jean-Luc Van Laethem, Calliope Maris and Nicky D’Haene
    Citation: Diagnostic Pathology 2021 16:117
    Content type: Case Report Published on:

  9. As a rare clinical tumor syndrome with an indolent clinical course and lack of pathognomonic symptoms, pseudomyxoma peritonei (PMP) is usually diagnosed at an advanced stage. In-depth pathological analysis is ...

    Authors: Ru Ma, Yu-Lin Lin, Xin-Bao Li, Feng-Cai Yan, Hong-Bin Xu, Zheng Peng and Yan Li
    Citation: Diagnostic Pathology 2021 16:116
    Content type: Research Published on:

  10. Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric ...

    Authors: Kanako Yoshiyasu, Hiroshi Kono, Yudai Hojo, Yoshinori Ishida, Akio Tamura, Keisuke Nakai, Tadayuki Oshima, Hiroto Miwa, Hisashi Shinohara and Seiichi Hirota
    Citation: Diagnostic Pathology 2021 16:115
    Content type: Case Report Published on:

  11. Monomorphic epitheliotropic T-cell lymphoma (MEITL) is an aggressive non-Hodgkin lymphoma with a high fatality rate. This study was aimed to explore the clinicopathological and molecular genetic features of ME...

    Authors: Chunni Chen, Yuxi Gong, Yefan Yang, Qiuyuan Xia, Qiu Rao, Yang Shao, Liuqing Zhu, Junli Zhang, Xiao Li, Pan Ji, Boya Zhai, Xiang Zhang and Zhihong Zhang
    Citation: Diagnostic Pathology 2021 16:114
    Content type: Research Published on:

  12. Many studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of malignant tumors have been published. The present study was performed to evaluate whether SOCS6 was significan...

    Authors: Jun Ouyang, Tailai An, Yan Wang, Xiaofang Lu, Yawei Zhang, Xiaokun Wang, Xinhua Zhang and Changhua Zhang
    Citation: Diagnostic Pathology 2021 16:113
    Content type: Research Published on:

  14. Endoscopic submucosal dissection (ESD) is a novel endoscopic treatment for early esophageal adenocarcinoma (EAC). The western pathologists’ experience with ESD specimens remains limited. This study aimed to co...

    Authors: Sadhna Dhingra, Firas Bahdi, Sarah B. May and Mohamed O. Othman
    Citation: Diagnostic Pathology 2021 16:111
    Content type: Research Published on:

  15. Immunotherapy is an important treatment in oncology, but only a fraction of patients with head and neck squamous cell carcinoma (HNSCC) benefit from it. Therefore, the aim of this study was to identify predict...

    Authors: Xuanli Xu, Rongrong Li, Lin Zhang, Guopei Zhu, Dandan Ren, Lijia Wu and Xiaoli Gong
    Citation: Diagnostic Pathology 2021 16:110
    Content type: Research Published on:

  16. Lymphovascular invasion (VI) is an established prognostic marker for many cancers including bladder cancer. There is a paucity of data regarding whether the prognostic significance of lymphatic invasion (LVI) ...

    Authors: Birgitte Carlsen, Tor Audun Klingen, Bettina Kulle Andreassen and Erik Skaaheim Haug
    Citation: Diagnostic Pathology 2021 16:109
    Content type: Research Published on:

  17. Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are extremely rare. Their pathogenesis and molecular landscape are largely unknown. Here, we report a case of mixed pancreatic intraduc...

    Authors: Jingci Chen, Pengyan Wang, Ke Lv and Weixun Zhou
    Citation: Diagnostic Pathology 2021 16:108
    Content type: Case Report Published on:

  18. Hereditary papillary renal cell carcinoma (HPRCC) is a rare autosomal dominant disease characterized by the development of multiple and bilateral papillary type I renal cell carcinomas (RCC) and papillary aden...

    Authors: Sophie Ferlicot, Pierre-Alexandre Just, Eva Compérat, Etienne Rouleau, Frédérique Tissier, Christophe Vaessen and Stéphane Richard
    Citation: Diagnostic Pathology 2021 16:107
    Content type: Case Report Published on:

  19. Microsatellite instability occurs due to a series of mutations in the DNA pairing error repair (Mismatch repair; MMR) genes, which can affect germ cells as occurs in Lynch syndrome, whose patients are at high ...

    Authors: Eduardo Sobrino-Reig, Telma Meizoso, Jesús García, David Varillas-Delgado and Yasmina B. Martin
    Citation: Diagnostic Pathology 2021 16:106
    Content type: Research Published on:

  20. Cervical cancer (CC) endangers women’s health in the world range. Accumulating studies have revealed the crucial regulatory role of long non-coding RNAs (lncRNAs) in multiple malignancies, including CC. Our st...

    Authors: Jihui Gu, Yi Liu, Ting Qi, Weiwei Qian, Dongdong Hu and Wen Feng
    Citation: Diagnostic Pathology 2021 16:105
    Content type: Research Published on:

  22. We present a unique case of primary breast CD20-positive extranodal NK/T cell lymphoma with stomach involvement in a young Chinese female patient.

    Authors: Ying Zhang, Kuansong Wang, Qian Tan, Keda Yang, Dengshu Wu, Yajing Xu, Xielan Zhao and Zhiping Jiang
    Citation: Diagnostic Pathology 2021 16:103
    Content type: Case Report Published on:

  23. Detection of the tumor-specific EWSR1/FUS-ETS fusion gene is essential to diagnose Ewing sarcoma. Reverse transcription–polymerase chain reaction (RT–PCR) and fluorescence in situ hybridization are commonly used ...

    Authors: Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Chikako Kiyotani, Motohiro Kato, Kimikazu Matsumoto, Nobutaka Kiyokawa, Atsuko Nakazawa and Takako Yoshioka
    Citation: Diagnostic Pathology 2021 16:102
    Content type: Research Published on:

  24. The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated.

    Authors: Yasuhito Mihashi, Shoichi Kimura, Hiromi Iwasaki, Yumi Oshiro, Yasushi Takamatsu, Shigeto Kawauchi, Shohei Shimajiri, Kenji Ishizuka and Morishige Takeshita
    Citation: Diagnostic Pathology 2021 16:101
    Content type: Research Published on:

  25. TP53 mutation is found frequently in therapy related acute myeloid leukemia (AML)/ myelodysplastic syndrome (MDS), AML and MDS patients with monosomy or complex karyotype. However, the prevalence and treatment...

    Authors: Pimjai Niparuck, Pornnapa Police, Phichchapha Noikongdee, Kanchana Siriputtanapong, Nittaya Limsuwanachot, Budsaba Rerkamnuaychoke, Suporn Chuncharunee and Teerapong Siriboonpiputtana
    Citation: Diagnostic Pathology 2021 16:100
    Content type: Research Published on:

  26. Extraosseous benign notochordal cell tumor is extremely rare, and there are only five reported cases worldwide. The presented case of pulmonary primary benign notochordal cell tumor is the sixth case, but the ...

    Authors: Kai Song, Xiaojing Ma, Jinghong Xu and Lirong Chen
    Citation: Diagnostic Pathology 2021 16:99
    Content type: Case Report Published on:

  27. Aurora-A kinase is important for cellular proliferation and is implicated in the tumorigenesis of several malignancies, including of the ovary. Information regarding the expression patterns of Aurora-A in norm...

    Authors: Khaled J. Alkhateeb, Jason E. Crane, Müge Sak, Caitlin J. Jorgensen, James P. O’Donnell, Cory T. Zumbar, Jason A. Wozniak, Clarence R. Salazar, Anil V. Parwani and Norman L. Lehman
    Citation: Diagnostic Pathology 2021 16:98
    Content type: Research Published on:

  28. Adult-onset Still’s disease (AOSD) often presents with systemic multiple lymphadenopathy. In addition to the common paracortical and mixed patterns in AOSD lymph node histopathological features, other morpholo...

    Authors: Zhonghua Huang, Hua Xu, Qinqin Min, Zhenguo Li, Jiaxin Bi, Lingyun Liu and Yingying Liang
    Citation: Diagnostic Pathology 2021 16:97
    Content type: Case Report Published on:

  29. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4 within the 12q13-15 chromosomal region. FRS2 gene was recently found to be consistently amplified in atypical lipoma...

    Authors: Wenyi Jing, Ting Lan, Yan Qiu, Ran Peng, Yang Lu, Huijiao Chen, Min Chen, Xin He, Chen Chen and Hongying Zhang
    Citation: Diagnostic Pathology 2021 16:96
    Content type: Research Published on:

  30. The precursors of clear cell endometrial carcinoma (CC-EC) are still undefined. Here, we deal with the diagnostic issues related to CC-EC precursors by presenting a morphological, immunophenotypical and molecu...

    Authors: Angela Santoro, Antonio Travaglino, Frediano Inzani, Damiano Arciuolo, Giuseppe Angelico, Nicoletta D’Alessandris, Giulia Scaglione, Michele Valente, Maurizio Martini, Antonio Raffone and Gian Franco Zannoni
    Citation: Diagnostic Pathology 2021 16:95
    Content type: Case Report Published on:

  31. Immune checkpoint proteins, especially PD-L1 and PD-1, play a crucial role in controlling the intensity and duration of the immune response, thus preventing the development of autoimmunity. These proteins play...

    Authors: Mohammed Akhtar, Sameera Rashid and Issam A. Al-Bozom
    Citation: Diagnostic Pathology 2021 16:94
    Content type: Review Published on:

    The Correction to this article has been published in Diagnostic Pathology 2022 17:50

  32. Circular RNAs (circRNAs) have become a hot topic in the area of tumor biology due to its closed structure and the post-transcriptional regulatory effect. This study aims to clarify the roles of circRNA nuclear...

    Authors: Chuang Li, Lijuan Zhu, Lijun Fu, Mingli Han, Ya Li, Zhaozhong Meng and Xinguang Qiu
    Citation: Diagnostic Pathology 2021 16:93
    Content type: Research Published on:

  33. Fine-needle aspiration cytology (FNAC) is a basic diagnostic tool for thyroid nodules. However, 15–30% of nodules are cytologically indeterminate. Midkine (MK), a pleiotropic growth factor, is often upregulate...

    Authors: Le Zhou, Jinxi Jiang, Yantao Fu, Daqi Zhang, Tong Li, Qingfeng Fu, Chao Yan, Yifan Zhong, Gianlorenzo Dionigi, Nan Liang and Hui Sun
    Citation: Diagnostic Pathology 2021 16:92
    Content type: Research Published on:

  34. The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour.

    Authors: A. Toferer, A. Truschnegg, K. Kashofer, C. Beham-Schmid and A. Beham
    Citation: Diagnostic Pathology 2021 16:91
    Content type: Case Report Published on:

  35. Acute fibrinous and organizing pneumonia (AFOP) is a rare histologic interstitial pneumonia pattern characterized by the intra-alveolar fibrin deposition and organizing pneumonia. Its clinical characteristics ...

    Authors: Haihong Chen, Yukun Kuang, Xinyan Huang, Ziyin Ye, Yangli Liu, Canmao Xie and Ke-Jing Tang
    Citation: Diagnostic Pathology 2021 16:90
    Content type: Case Report Published on:

  36. Secretory breast carcinoma is an uncommon subset of breast cancer that usually has a favorable outcome. Although initially described in children, it also occurs in adults where it may metastasize, possibly res...

    Authors: Jing Lian, Li-Xia Wang, Jiang-hong Guo, Peng Bu, Yan-feng Xi and Ke-ming Yun
    Citation: Diagnostic Pathology 2021 16:89
    Content type: Case Report Published on:

  37. COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, is a severe systemic thrombotic syndrome that emerged in 2019, with an ensuing pandemic.

    Authors: Giovanna Giordano, Chiara Petrolini, Emilia Corradini, Nicoletta Campanini, Susanna Esposito and Serafina Perrone
    Citation: Diagnostic Pathology 2021 16:88
    Content type: Case Report Published on:

  39. Thyroid tumors are often difficult to histopathologically diagnose, particularly follicular adenoma (FA) and follicular carcinoma (FC). Papillary carcinoma (PAC) has several histological subtypes. Periostin (P...

    Authors: Kimihide Kusafuka, Masaru Yamashita, Tomohiro Iwasaki, Chinatsu Tsuchiya, Aki Kubota, Kazuki Hirata, Akinori Murakami, Aya Muramatsu, Kazumori Arai and Makoto Suzuki
    Citation: Diagnostic Pathology 2021 16:86
    Content type: Short report Published on:

  41. The incidence of papillary thyroid carcinoma (PTC) has been steadily increasing over the past decades. Hashimoto’s thyroiditis (HT) is the most common autoimmune disease, and is related to the pathogenesis of ...

    Authors: Chumeng Zhu, Yuechu Dai, Hui Zhang, Yanyun Ruan, Yong Zhou, Yingjie Dai, Lilong Fan, Tianjun Jia, Hongsheng Lu and Qi Chen
    Citation: Diagnostic Pathology 2021 16:84
    Content type: Research Published on:

  42. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in multiple organs associated with germline mutations in TSC1 and TSC2, including exonic, intronic, or mosaic mutatio...

    Authors: Bogyeong Han, Juhwan Lee, Yoon Jin Kwak, Hyun-Young Kim, Kwang Hoon Lee, Yumi Shim, Hyunju Lee and Sung-Hye Park
    Citation: Diagnostic Pathology 2021 16:83
    Content type: Case Report Published on:

  43. A high incidence of malignant tumors, such as post-transplant lymphoproliferative disorders (PTLD), Kaposi sarcoma, and renal cancer is common in solid organ and bone marrow transplant recipients. However, mye...

    Authors: Danyang Wu, Xiaoxuan Lu, Xiaojing Yan and Ran Gao
    Citation: Diagnostic Pathology 2021 16:82
    Content type: Case Report Published on:

  44. Congenital hepatic fibrosis (CHF) is a rare inherited form of ductal plate malformation associated with polycystic kidney disease. The diagnosis requires histopathologic confirmation, but can be challenging to...

    Authors: Irene Y. Chen, Christa L. Whitney-Miller and Xiaoyan Liao
    Citation: Diagnostic Pathology 2021 16:81
    Content type: Research Published on:

  46. A definitive diagnosis of malignant peripheral nerve sheath tumor (MPNST) is challenging, especially in cases without neurofibromatosis 1 (NF1), because MPNST lacks specific markers on immunohistochemistry (IHC).

    Authors: Shintaro Sugita, Tomoyuki Aoyama, Makoto Emori, Tomomi Kido, Tomoko Takenami, Kodai Sakuraba, Kotomi Terai, Taro Sugawara, Mitsuhiro Tsujiwaki and Tadashi Hasegawa
    Citation: Diagnostic Pathology 2021 16:79
    Content type: Research Published on:

  48. Histopathological classification of Wilms tumors determines treatment regimen. Machine learning has been shown to contribute to histopathological classification in various malignancies but requires large numbe...

    Authors: Jikke J. Rutgers, Tessa Bánki, Ananda van der Kamp, Tomas J. Waterlander, Marijn A. Scheijde-Vermeulen, Marry M. van den Heuvel-Eibrink, Jeroen A. W. M. van der Laak, Marta Fiocco, Annelies M. C. Mavinkurve-Groothuis and Ronald R. de Krijger
    Citation: Diagnostic Pathology 2021 16:77
    Content type: Research Published on:

  49. First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 year...

    Authors: Charlotte Holmes, Peh Sun Loo and Sion Barnard
    Citation: Diagnostic Pathology 2021 16:76
    Content type: Case Report Published on:

  50. There are recognised potential pitfalls in digital diagnosis in urological pathology, including the grading of dysplasia. The World Health Organisation/International Society of Urological Pathology (WHO/ISUP) ...

    Authors: Lisa Browning, Richard Colling and Clare Verrill
    Citation: Diagnostic Pathology 2021 16:75
    Content type: Short report Published on:
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