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  1. Content type: Research

    Intestinal metaplasia (IM) of the gastric mucosa is classified as complete (Type I) and incomplete IM (Type II and III) subtypes, which showed significantly different risk for developing to gastric adenocarcin...

    Authors: Xiaojian Duan, Hongwei Lian, Jie Li, Benyan Wu, Weihua Wang, Tao Wu, Changzheng Wang, Yan Dou, Zhongren Zhou, Bingzhi Wang, Liyan Xue and Gangshi Wang

    Citation: Diagnostic Pathology 2019 14:61

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  2. Content type: Research

    Adenosquamous carcinoma (ADSC) of the lung, a rare but aggressive subtype of non-small cell lung cancer (NSCLC), is defined as a carcinoma containing components of adenocarcinoma (ADC) and squamous cell carcin...

    Authors: Hsiang-Ling Ho, Hua-Lin Kao, Yi-Chen Yeh and Teh-Ying Chou

    Citation: Diagnostic Pathology 2019 14:59

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  3. Content type: Research

    Evaluation of core needle biopsies (CNB) is a standard procedure for the diagnosis of breast cancer. However, tissue processing and image preparation is a time- consuming procedure and instant on-site availabi...

    Authors: C. Elfgen, B. Papassotiropoulos, Z. Varga, L. Moskovszky, M. Nap, U. Güth, A. Baege, E. Amann, F. Chiesa and C. Tausch

    Citation: Diagnostic Pathology 2019 14:58

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    The Correction to this article has been published in Diagnostic Pathology 2019 14:87

  4. Content type: Short report

    Systemic amyloidosis is a devastating group of disorders for which there is no current cure. The treatment goal is to reduce the burden of amyloidogenic protein precursors. The treatment is only effective if a...

    Authors: Ashraf El-Meanawy, Christopher Mueller and Kenneth A. Iczkowski

    Citation: Diagnostic Pathology 2019 14:57

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  5. Content type: Research

    Standard treatment with a thiotepa-based regimen in countries with a limited resource is less feasible. Aims of the study were to evaluate the treatment outcome, and identify the prognostic factors in patients...

    Authors: Pimjai Niparuck, Paisarn Boonsakan, Taksayut Sutthippingkiat, Sulada Pukiat, Pichika Chantrathammachart, Sithakom Phusanti, Kochawan Boonyawat, Teeraya Puavilai, Pantep Angchaisuksiri, Artit Ungkanont, Suporn Chuncharunee and Vichai Atichartakarn

    Citation: Diagnostic Pathology 2019 14:56

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  6. Content type: Research

    Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion and metastasis. In ...

    Authors: Jihong Liu, Chunxiao Li, Liyan Zhang, Kai Liu, Xianli Jiang, Xueli Wang, Lan Yang, Weihua Liang, Kunping Liu, Jianming Hu and Feng Li

    Citation: Diagnostic Pathology 2019 14:55

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  7. Content type: Case Report

    Endometrial mesonephric-like adenocarcinomas exhibit classical histologic features of mesonephric carcinoma; however, it remains unclear whether these tumors represent mesonephric (Wolffian) carcinoma or endom...

    Authors: Mitsutake Yano, Daisuke Shintani, Tomomi Katoh, Mei Hamada, Kozue Ito, Eito Kozawa, Kosei Hasegawa and Masanori Yasuda

    Citation: Diagnostic Pathology 2019 14:54

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  8. Content type: Research

    Lung cancer is one of the common malignant tumors worldwide with high incidence and mortality. MicroRNA-423-3p (miR-423-3p) acts as an oncogene in several types of cancers. The aim of this study is to reveal t...

    Authors: Rukun Wang, Gaofeng Li, Guoyan Zhuang, Shuying Sun and Zhihui Song

    Citation: Diagnostic Pathology 2019 14:53

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  9. Content type: Research

    The incidence of coexisting papillary thyroid cancer (PTC) and Hashimoto’s thyroiditis (HT) is increasing. The impact of HT on PTC prognosis and its possible mechanism remains controversial. Interleukin-17A (I...

    Authors: Li-Tao Han, Jia-Qian Hu, Ben Ma, Duo Wen, Ting-Ting Zhang, Zhong-Wu Lu, Wen-Jun Wei, Yu-Long Wang, Yu WANG, Tian Liao and Qing-Hai Ji

    Citation: Diagnostic Pathology 2019 14:52

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  10. Content type: Case Report

    As a new entity included in the 4th edition of the WHO classification of tumours of soft tissue and bone in 2013, hybrid peripheral nerve sheath tumours are benign composite neoplasms that demonstrate features...

    Authors: Yuejiao Lang, Dawei Liu, Pei Xiang, Jilin Wang and Yang Li

    Citation: Diagnostic Pathology 2019 14:51

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  11. Content type: Research

    The aim of the present study was to identify specific serum miRNAs (preoperative serum samples compared to healthy controls) as potential diagnostic markers for detection in laryngeal squamous cell carcinoma (...

    Authors: Weronika Lucas Grzelczyk, Janusz Szemraj, Sylwia Kwiatkowska and Magdalena Józefowicz-Korczyńska

    Citation: Diagnostic Pathology 2019 14:49

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  12. Content type: Research

    p16/Ki-67 dual immunocytochemical staining (DS) has been proven as a sensitive and specific test for triage of HPV positive women with good reproducibility and accuracy. However, implementation of the test int...

    Authors: Veronika Kloboves Prevodnik, Tine Jerman, Nataša Nolde, Alenka Repše Fokter, Sandra Jezeršek, Živa Pohar Marinšek, Ulrika Klopčič, Simona Hutter Čelik, Kristina Gornik Kramberger, Maja Primic Žakelj and Urška Ivanuš

    Citation: Diagnostic Pathology 2019 14:48

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  13. Content type: Research

    Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibo...

    Authors: Luka Brcic, Christian Kuchler, Sylvia Eidenhammer, Daniela Pabst, Franz Quehenberger, Adi F. Gazdar and Helmut Popper

    Citation: Diagnostic Pathology 2019 14:47

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  14. Content type: Case Report

    Tumor-to-tumor metastasis is a well-recognized but uncommon entity. Breast carcinoma is one of the most common metastatic donors. Breast carcinoma metastasizes commonly to adrenal glands. However, the co-exist...

    Authors: Weiwei Tan, Lili Tao, Zhuping Zhou, Weihua Yin and Yaoli Chen

    Citation: Diagnostic Pathology 2019 14:46

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  15. Content type: Case Report

    Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a rare intracranial tumor, defined as DLBCL arising from the brain, spinal cord, leptomeninges and eye, with an overall annual inci...

    Authors: Tianqi Xu, Qingge Jia, Yingmei Wang, Yixiong Liu, Donghui Han, Peifeng Li, Jing Ma, Linni Fan, Qingguo Yan, Shuangping Guo, Mingyang Li and Zhe Wang

    Citation: Diagnostic Pathology 2019 14:45

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  16. Content type: Retraction Note

    The Editor-in-Chief has retracted this article [1] because Fig. 3 shows overlap with Fig. 6 in [2], Fig. 2b in [3] and Fig. 6a in [4]. An investigation by Zhengzhou University has confirmed that these figures ...

    Authors: Tao Wang, Yanfang Mi, Linping Pian, Ping Gao, Hong Xu, Yuling Zheng and Xiaoyan Xuan

    Citation: Diagnostic Pathology 2019 14:44

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    The original article was published in Diagnostic Pathology 2013 8:104

  17. Content type: Case Report

    Desmoplastic small round cell tumor (DSRCT) is a rare soft tissue tumor that generally involves the retroperitoneum, pelvis, omentum and mesentery in younger patients. However, extra-abdominal DSRCT is very rare.

    Authors: Kanako C. Hatanaka, Emi Takakuwa, Yutaka Hatanaka, Akira Suzuki, Satoshi IIzuka, Nayuta Tsushima, Tomoko Mitsuhashi, Shintaro Sugita, Akihiro Homma, Shojiroh Morinaga, Tadashi Hashegawa and Yoshihiro Matsuno

    Citation: Diagnostic Pathology 2019 14:43

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  18. Content type: Case Report

    According to WHO, succinate dehydrogenase (SDH)–deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SD...

    Authors: Marina Ugarte-Camara, Raul Fernandez-Prado, Isabel Lorda, Gabriela Rossello, Carmen Gonzalez-Enguita, Pablo Cannata-Ortiz and Alberto Ortiz

    Citation: Diagnostic Pathology 2019 14:42

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  19. Content type: Case Report

    Lipoprotein glomerulopathy (LPG) is a rare kidney disease with a poor prognosis that is related to mutation of the apoE gene. More than 10 variants of apoE associated with LPG have currently been identified.

    Authors: Weiji Xie, Yi Xie, Zhijun Lin, Xiaochang Xu and Yimin Zhang

    Citation: Diagnostic Pathology 2019 14:41

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  20. Content type: Research

    Henoch-Schönlein purpura nephritis (HSPN) shares many similarities with IgA nephropathy. We aimed to analyze the predictive value of the International Study of Kidney Disease in Children (ISKDC) classification...

    Authors: Xiaohan Huang, Lili Ma, Pingping Ren, Hongya Wang, Liangliang Chen, Haidongqin Han, Jianghua Chen and Fei Han

    Citation: Diagnostic Pathology 2019 14:40

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  21. Content type: Research

    One of the major challenges remaining in the classification of thyroid tumor is the determination of whether a nodule is benign or malignant. We aimed to characterize the mutational profiles of follicular thyr...

    Authors: Huanli Duan, Xiaoding Liu, Xinyu Ren, Hui Zhang, Huanwen Wu and Zhiyong Liang

    Citation: Diagnostic Pathology 2019 14:39

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  22. Content type: Case Report

    Gastric mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are infrequently encountered in routine practice. Some gastric neuroendocrine carcinomas (NECs) have a variety of differentiation patterns; ho...

    Authors: Yasuko Fujita, Noriyuki Uesugi, Ryo Sugimoto, Makoto Eizuka, Takayuki Matsumoto and Tamotsu Sugai

    Citation: Diagnostic Pathology 2019 14:38

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  23. Content type: Case Report

    Diagnoses reflect clear cell morphologies when tumor cells have clear cytoplasm in many organs, and the nature of such clear cells is typically identified. Colorectal tubular adenoma or adenocarcinoma, convers...

    Authors: Yuzo Oyama, Haruto Nishida, Takahiro Kusaba, Hiroko Kadowaki, Motoki Arakane, Kazuhisa Okamoto, Junpei Wada, Shogo Urabe and Tsutomu Daa

    Citation: Diagnostic Pathology 2019 14:37

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  24. Content type: Research

    DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as micr...

    Authors: Benjamin Goeppert, Stephanie Roessler, Marcus Renner, Moritz Loeffler, Stephan Singer, Melina Rausch, Thomas Albrecht, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Elena Czink, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Peter Schirmacher…

    Citation: Diagnostic Pathology 2019 14:36

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  25. Content type: Research

    The concordance rate of human epidermal growth factor receptor 2 (HER2) status between core needle biopsy (CNB) and subsequent excisional biopsies of the same tumor varies from 81 to 96%, which may cause inapp...

    Authors: Huimin Zhang, Peiling Xie, Zhuoying Li, Rong Huang, Weiliang Feng, Yanan Kong, Feng Xu, Lin Zhao, Qingkun Song, Jing Li, Baoning Zhang, Jinhu Fan, Youlin Qiao, Xiaoming Xie, Shan Zheng, Jianjun He…

    Citation: Diagnostic Pathology 2019 14:35

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  26. Content type: Research

    Desmoid-type fibromatosis (DTF) is a lesion characterized by clonal proliferation of myofibroblasts, which exhibits an infiltrative growth pattern. It is necessary for them to be distinguished from other fibro...

    Authors: Luting Zhou, Haimin Xu, Jun Zhou, Lei Dong, Peipei Zhang, Xiaoqun Yang and Chaofu Wang

    Citation: Diagnostic Pathology 2019 14:34

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  27. Content type: Research

    SNW1 is a nuclear receptor co-activator involved in splicing and transcription control, including androgen receptor signaling. Overexpression of SNW1 has been linked to adverse prognosis in different cancer ty...

    Authors: Doris Höflmayer, Carla Willich, Claudia Hube-Magg, Ronald Simon, Dagmar Lang, Emily Neubauer, Frank Jacobsen, Andrea Hinsch, Andreas M. Luebke, Marie Christina Tsourlakis, Hartwig Huland, Markus Graefen, Alexander Haese, Hans Heinzer, Sarah Minner, Franziska Büscheck…

    Citation: Diagnostic Pathology 2019 14:33

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  28. Content type: Case Report

    Uterine leiomyomas, in contrast to sarcomas, tend to cease growth following menopause. In the setting of a rapidly enlarging uterine mass in a postmenopausal patient, clinical distinction of uterine leiomyoma ...

    Authors: Alessandra J. Ainsworth, Nooshin K. Dashti, Taofic Mounajjed, Karen J. Fritchie, Jaime Davila, Rohini Mopuri, Rory A. Jackson, Kevin C. Halling, Jamie N. Bakkum-Gamez and J. Kenneth Schoolmeester

    Citation: Diagnostic Pathology 2019 14:32

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  29. Content type: Research

    Linear Array Genotyping Test (LA) is one of the gold standards used for Human Papillomavirus (HPV) genotyping, however, since its launching in 2006, new HPV genotypes are still being characterized with the use...

    Authors: Cristina Artaza-Irigaray, María Guadalupe Flores-Miramontes, Dominik Olszewski, Verónica Vallejo-Ruiz, Laura Patricia Limón-Toledo, Cibeles Sánchez-Roque, Rocío Mayoral-Torres, Luis Felipe Jave-Suárez and Adriana Aguilar-Lemarroy

    Citation: Diagnostic Pathology 2019 14:31

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  30. Content type: Case Report

    Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

    Authors: Aoife J. McCarthy, Blaise A. Clarke, Ian McGilvray, Brendan C. Dickson, Korosh Khalili and Runjan Chetty

    Citation: Diagnostic Pathology 2019 14:30

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  31. Content type: Review

    Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology...

    Authors: Matthew D. Wood, Aaron M. Halfpenny and Stephen R. Moore

    Citation: Diagnostic Pathology 2019 14:29

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  32. Content type: Research

    Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumo...

    Authors: Nasir Uddin, Maha Zubair, Jamshid Abdul-Ghafar, Zia Ullah Khan and Zubair Ahmad

    Citation: Diagnostic Pathology 2019 14:28

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  33. Content type: Case Report

    Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and...

    Authors: Mitsumasa Osakabe, Chie Sato, Masamichi Suzuki, Ryo Sugimoto, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Hiroaki Itamochi, Tsukasa Baba and Tamotsu Sugai

    Citation: Diagnostic Pathology 2019 14:27

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  34. Content type: Case Report

    Myeloid sarcoma (MS) is a rare neoplasm of immature myeloid precursors that form tumor mass outside the bone marrow. The diagnosis of de novo MS can be challenging, particularly in patients with no prior histo...

    Authors: Haiyan Bao, Juehua Gao, Yi-Hua Chen, Jessica K. Altman, Olga Frankfurt, Amanda L. Wilson, Madina Sukhanova, Qing Chen and Xinyan Lu

    Citation: Diagnostic Pathology 2019 14:26

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  35. Content type: Research

    Histopathological analysis is the cornerstone in bladder cancer (BCa) diagnosis. These analysis suffer from a moderate observer agreement in the staging of bladder cancer. Three-dimensional reconstructions hav...

    Authors: Ilaria Jansen, Marit Lucas, C. Dilara Savci-Heijink, Sybren L. Meijer, Esmee I. M. L. Liem, Onno J. de Boer, Ton G. van Leeuwen, Henk A. Marquering and Daniel M. de Bruin

    Citation: Diagnostic Pathology 2019 14:25

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  36. Content type: Research

    Previous studies reported the early diagnostic values of plasma Epstein-Barr virus (EBV)-DNA. The present study aimed to assess the relationship between the concentration of plasma EBV-DNA and the number of CD8+P...

    Authors: Qi Chen, Wei Hu, Huacai Xiong, Shenpeng Ying, Yanyun Ruan, Bo Wu and Hongsheng Lu

    Citation: Diagnostic Pathology 2019 14:23

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  37. Content type: Case Report

    Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The gen...

    Authors: Andrew Mitchell and Alexandre Dugas

    Citation: Diagnostic Pathology 2019 14:22

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  38. Content type: Case Report

    A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Both children and adults can be affected b...

    Authors: Tatiana S. Belysheva, Yana V. Vishnevskaya, Tatiana V. Nasedkina, Marina A. Emelyanova, Ivan S. Abramov, Kristina V. Orlova, Ludmila N. Lubchenko, Igor A. Utyashev, Marina B. Doroshenko, Lev V. Demidov and Mamed D. Aliev

    Citation: Diagnostic Pathology 2019 14:21

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  39. Content type: Case Report

    Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm but it rarely occurs in the parotid gland. The histological features are variable, with the majority having spindle cell morphology and non-spe...

    Authors: Chien-Kuan Lee, Ken-Liao Liu and Sheng-Kai Huang

    Citation: Diagnostic Pathology 2019 14:20

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  40. Content type: Case Report

    Laser-interstitial thermal therapy (LITT) has been supported by some authors as an ablative treatment of glioblastoma multiforme (GBM). Although the effects of LITT have been modeled in vivo, the histologic ef...

    Authors: J. Bradley Elder, Kristin Huntoon, Jose Otero, Behiye Kaya, Jeff Hatef, Mostafa Eltobgy and Russell R. Lonser

    Citation: Diagnostic Pathology 2019 14:19

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  41. Content type: Research

    Molecular testing of lung adenocarcinoma for oncogenic driver mutations has become standard in pathology practice. The aim of the study was to analyze the EGFR, KRAS, ALK, RET, ROS1, BRAF, ERBB2, MET and PIK3CA m...

    Authors: Alexandra Grosse, Claudia Grosse, Markus Rechsteiner and Alex Soltermann

    Citation: Diagnostic Pathology 2019 14:18

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  42. Content type: Case Report

    Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), whic...

    Authors: Kazuaki Suda, Hirofumi Nakaoka, Chihiro Hata, Natsumi Yahata, Masanori Isobe, Hitoshi Kameyama, Toshifumi Wakai, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara and Takayuki Enomoto

    Citation: Diagnostic Pathology 2019 14:17

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  43. Content type: Case Report

    Gliomas with 1p/19q-codeletion as well as mutation of isocitrate dehydrogenase (IDH) 1 are typically characterized as oligodendrogliomas with comparatively good response to treatment with radiation and chemothera...

    Authors: Carlos G. Romo, Doreen N. Palsgrove, Ananyaa Sivakumar, Christen R. Elledge, Lawrence R. Kleinberg, Kaisorn L. Chaichana, Christopher D. Gocke, Fausto J. Rodriguez and Matthias Holdhoff

    Citation: Diagnostic Pathology 2019 14:16

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  44. Content type: Research

    Intramuscular myxoma (IM) is a hypocellular benign soft tissue neoplasm characterized by abundant myxoid stroma and occasional hypercellular areas. These tumors can, especially on biopsy material, be difficult...

    Authors: Elise M. Bekers, Astrid Eijkelenboom, Paul Rombout, Peter van Zwam, Suzanne Mol, Emiel Ruijter, Blanca Scheijen and Uta Flucke

    Citation: Diagnostic Pathology 2019 14:15

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  45. Content type: Research

    Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with poor long-term survival, which warrants studies aimed at clarifying the pathogenesis of this disease in order to widen the scope of therapeuti...

    Authors: João Augusto Vianna Goulart-Filho, Victor Angelo Martins Montalli, Fabrício Passador-Santos, Ney Soares de Araújo and Vera Cavalcanti de Araújo

    Citation: Diagnostic Pathology 2019 14:14

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  46. Content type: Research

    Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis. There are no specific immunohistochemical ...

    Authors: Nasir Uddin, Khurram Minhas, Jamshid Abdul-Ghafar, Arsalan Ahmed and Zubair Ahmad

    Citation: Diagnostic Pathology 2019 14:13

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  47. Content type: Research

    Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.

    Authors: Bohyun Kim, Han-Seong Kim and Kyung Chul Moon

    Citation: Diagnostic Pathology 2019 14:12

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